Design, structure–activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists

A series of novel and potent 3-phenyl-4-benzylaminopiperidine tachykinin NK1 antagonists are described. Highly efficient asymmetric synthesis of this series is achieved via dynamic kinetic resolution. We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified...

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