Sub-chronic effect of perfluorooctanesulfonate (PFOS) on the balance of type 1 and type 2 cytokine in adult C57BL6 mice

As a ubiquitous and highly persistent environmental contaminant, the clear mechanisms to explain any perfluorooctanesulfonate (PFOS)-induced immunotoxicity are still unknown. This study here sought to examine the ability of PFOS to potentially perturb T-helper (T H )-1 and T H -2 cell cytokine secre...

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Veröffentlicht in:	Archives of toxicology 2011-10, Vol.85 (10), p.1235-1244
Hauptverfasser:	Dong, Guang-Hui, Liu, Miao-Miao, Wang, Da, Zheng, Li, Liang, Zai-Fu, Jin, Yi-He
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkanesulfonic Acids - adverse effects Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Body Weight - drug effects Contaminants Cytokines Cytokines - metabolism Dose-Response Relationship, Drug Eating - drug effects Environmental Health Environmental Pollutants - adverse effects Enzyme-Linked Immunosorbent Assay Fluorocarbons - adverse effects Immunoglobulin G - blood Immunoglobulin M - blood Immunology Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-2 - metabolism Interleukin-4 - metabolism Male Medical sciences Mice Mice, Inbred C57BL Molecular Toxicology Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Rodents Sheep Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - metabolism Toxicity Toxicity Tests, Subchronic Toxicology
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