Overexpression of Jazf1 induces cardiac malformation through the upregulation of pro-apoptotic genes in mice

The transcription factor Juxtaposed with another zinc finger gene 1 (JAZF1) is a zinc finger protein that binds to the nuclear orphan receptor TR4. Recent evidence indicates that TR4 receptor functions as both a positive and negative regulator of transcription, but the role of JAZF1 in transcription...

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Veröffentlicht in:	Transgenic research 2011-10, Vol.20 (5), p.1019-1031
Hauptverfasser:	Bae, Ki Beom, Kim, Myoung Ok, Yu, Dong Hoon, Shin, Mi Jung, Kim, Hei Jung, Yuh, Hyung Soo, Ji, Young Rae, Kim, Jae-Young, Kim, Jin Man, Hyun, Byung Hwa, Lee, Hwi Cheul, Chang, Won Kyong, Park, Soo Bong, Kim, Do Hyung, Lee, Hyun-Shik, Choo, Yeon-Sik, Lee, Sanggyu, Ryoo, Zae Young
Format:	Artikel
Sprache:	eng
Schlagworte:	abnormal development adults Animal Genetics and Genomics Animal models Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biotechnology Blood Pressure cardiomyocytes Carrier Proteins - genetics Carrier Proteins - metabolism Congenital defects Disease Models, Animal EKG Electrocardiography Fundamental and applied biological sciences. Psychology Gene expression gene expression regulation Gene Expression Regulation, Developmental gene overexpression genes Genetic Engineering Genetic technics Heart Heart - embryology Heart - growth & development Heart Defects, Congenital - genetics Heart diseases heart failure Heart Failure - genetics Heart rate Hypertension Life Sciences messenger RNA Methods. Procedures. Technologies Mice Mice, Transgenic Mitochondria Molecular Medicine Neonates Nuclear Proteins - genetics Nuclear Proteins - metabolism Original Paper Orphan receptors patients Plant Genetics and Genomics Polycomb Repressive Complex 2 Recklinghausen's disease Repressor Proteins - genetics Repressor Proteins - metabolism RNA, Messenger - metabolism Survival Transcription factors Transgenic animals and transgenic plants Transgenic mice Transgenics zinc finger motif Zinc finger proteins
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