M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma
To test the M31R and R335C polymorphisms of the Il8RA gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients from Moscow and Buryat patients from Ulan-Ude. The study involved two Russian groups, on...
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| Veröffentlicht in: | Russian journal of genetics 2011-09, Vol.47 (9), p.1111-1116 |
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| creator | Voronko, O. E. Dmitrieva-Zdorova, E. V. Gabaeva, M. V. Latysheva, E. A. Storozhakov, G. I. Lemza, S. V. Hobrakova, V. B. Grigorieva, E. V. Bodoev, N. V. |
| description | To test the
M31R
and
R335C
polymorphisms of the
Il8RA
gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients from Moscow and Buryat patients from Ulan-Ude. The study involved two Russian groups, one including 291 DNA samples of patients with atopic BA, and the other, 266 DNA samples of healthy people. The two Buryat groups included 124 and 152 DNA samples from patients with atopic BA and healthy people, respectively. The M31R polymorphism proved to be associated with atopic BA in Russians. Allele
Arg
and genotype
Met/Arg
suggested a higher risk of BA (OR = 4.45,
P
= 0.003 and OR = 4.58,
P
= 0.003, respectively), while allele
Met
and genotype
Met/Met
were associated with a lower risk (OR = 0.22,
P
= 0.003 and OR = 0.22,
P
= 0.003, respectively). The R335C polymorphism was not associated with atopic BA in Russians and was in Buryats. Allele
Arg
and homozygous genotype
Arg/Arg
suggested a higher risk of the disease (OR = 3.06,
P
= 0.030 and OR = 3.20,
P
= 0.027, respectively), while allele
Cys
and genotype
Arg/Cys
suggested a lower risk (OR = 0.33,
P
= 0.030 and OR = 0.31,
P
= 0.027, respectively). The results support the role of the
IL8RA
gene in atopic BA. |
| doi_str_mv | 10.1134/S1022795411090171 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902372033</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902372033</sourcerecordid><originalsourceid>FETCH-LOGICAL-c272t-5e0304e63042dbb3080c34ba5aaa2c16d11f4f5d5d48e4ca7ae906a085a1c3f13</originalsourceid><addsrcrecordid>eNp9kEtPwzAQhCMEEqXwA7j5ximwa-d5LBWPSkVIAc7R1nGaVGmc2g6o_x6XckPisrvSzDfSThBcI9wiiujuDYHzNI8jRMgBUzwJJphAFgqR5Kf-9nJ40M-DC2s3AAiQiEmwexFYMOorVggRz9mgu_1Wm6FpJfsk01LvLNM1c41ii2VWzNha9Yq1PStGa738w96PZk-ODeRadQC-WtcwcnrwKSuje9m01DGyrtnSZXBWU2fV1e-eBh-PD-_z53D5-rSYz5ah5Cl3YaxAQKQSP3i1WgnIQIpoRTERcYlJhVhHdVzFVZSpSFJKKoeEIIsJpahRTIObY-5g9G5U1pXb1krVddQrPdoyBy5SDkJ4Jx6d0mhrjarLwbRbMvsSoTy0W_5p1zP8yFjv7dfKlBs9mt4_9A_0DQYlewQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>902372033</pqid></control><display><type>article</type><title>M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma</title><source>Springer Nature - Complete Springer Journals</source><creator>Voronko, O. E. ; Dmitrieva-Zdorova, E. V. ; Gabaeva, M. V. ; Latysheva, E. A. ; Storozhakov, G. I. ; Lemza, S. V. ; Hobrakova, V. B. ; Grigorieva, E. V. ; Bodoev, N. V.</creator><creatorcontrib>Voronko, O. E. ; Dmitrieva-Zdorova, E. V. ; Gabaeva, M. V. ; Latysheva, E. A. ; Storozhakov, G. I. ; Lemza, S. V. ; Hobrakova, V. B. ; Grigorieva, E. V. ; Bodoev, N. V.</creatorcontrib><description>To test the
M31R
and
R335C
polymorphisms of the
Il8RA
gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients from Moscow and Buryat patients from Ulan-Ude. The study involved two Russian groups, one including 291 DNA samples of patients with atopic BA, and the other, 266 DNA samples of healthy people. The two Buryat groups included 124 and 152 DNA samples from patients with atopic BA and healthy people, respectively. The M31R polymorphism proved to be associated with atopic BA in Russians. Allele
Arg
and genotype
Met/Arg
suggested a higher risk of BA (OR = 4.45,
P
= 0.003 and OR = 4.58,
P
= 0.003, respectively), while allele
Met
and genotype
Met/Met
were associated with a lower risk (OR = 0.22,
P
= 0.003 and OR = 0.22,
P
= 0.003, respectively). The R335C polymorphism was not associated with atopic BA in Russians and was in Buryats. Allele
Arg
and homozygous genotype
Arg/Arg
suggested a higher risk of the disease (OR = 3.06,
P
= 0.030 and OR = 3.20,
P
= 0.027, respectively), while allele
Cys
and genotype
Arg/Cys
suggested a lower risk (OR = 0.33,
P
= 0.030 and OR = 0.31,
P
= 0.027, respectively). The results support the role of the
IL8RA
gene in atopic BA.</description><identifier>ISSN: 1022-7954</identifier><identifier>EISSN: 1608-3369</identifier><identifier>DOI: 10.1134/S1022795411090171</identifier><language>eng</language><publisher>Dordrecht: SP MAIK Nauka/Interperiodica</publisher><subject>Animal Genetics and Genomics ; Biomedical and Life Sciences ; Biomedicine ; Human Genetics ; Microbial Genetics and Genomics</subject><ispartof>Russian journal of genetics, 2011-09, Vol.47 (9), p.1111-1116</ispartof><rights>Pleiades Publishing, Ltd. 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c272t-5e0304e63042dbb3080c34ba5aaa2c16d11f4f5d5d48e4ca7ae906a085a1c3f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S1022795411090171$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S1022795411090171$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Voronko, O. E.</creatorcontrib><creatorcontrib>Dmitrieva-Zdorova, E. V.</creatorcontrib><creatorcontrib>Gabaeva, M. V.</creatorcontrib><creatorcontrib>Latysheva, E. A.</creatorcontrib><creatorcontrib>Storozhakov, G. I.</creatorcontrib><creatorcontrib>Lemza, S. V.</creatorcontrib><creatorcontrib>Hobrakova, V. B.</creatorcontrib><creatorcontrib>Grigorieva, E. V.</creatorcontrib><creatorcontrib>Bodoev, N. V.</creatorcontrib><title>M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma</title><title>Russian journal of genetics</title><addtitle>Russ J Genet</addtitle><description>To test the
M31R
and
R335C
polymorphisms of the
Il8RA
gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients from Moscow and Buryat patients from Ulan-Ude. The study involved two Russian groups, one including 291 DNA samples of patients with atopic BA, and the other, 266 DNA samples of healthy people. The two Buryat groups included 124 and 152 DNA samples from patients with atopic BA and healthy people, respectively. The M31R polymorphism proved to be associated with atopic BA in Russians. Allele
Arg
and genotype
Met/Arg
suggested a higher risk of BA (OR = 4.45,
P
= 0.003 and OR = 4.58,
P
= 0.003, respectively), while allele
Met
and genotype
Met/Met
were associated with a lower risk (OR = 0.22,
P
= 0.003 and OR = 0.22,
P
= 0.003, respectively). The R335C polymorphism was not associated with atopic BA in Russians and was in Buryats. Allele
Arg
and homozygous genotype
Arg/Arg
suggested a higher risk of the disease (OR = 3.06,
P
= 0.030 and OR = 3.20,
P
= 0.027, respectively), while allele
Cys
and genotype
Arg/Cys
suggested a lower risk (OR = 0.33,
P
= 0.030 and OR = 0.31,
P
= 0.027, respectively). The results support the role of the
IL8RA
gene in atopic BA.</description><subject>Animal Genetics and Genomics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Human Genetics</subject><subject>Microbial Genetics and Genomics</subject><issn>1022-7954</issn><issn>1608-3369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPwzAQhCMEEqXwA7j5ximwa-d5LBWPSkVIAc7R1nGaVGmc2g6o_x6XckPisrvSzDfSThBcI9wiiujuDYHzNI8jRMgBUzwJJphAFgqR5Kf-9nJ40M-DC2s3AAiQiEmwexFYMOorVggRz9mgu_1Wm6FpJfsk01LvLNM1c41ii2VWzNha9Yq1PStGa738w96PZk-ODeRadQC-WtcwcnrwKSuje9m01DGyrtnSZXBWU2fV1e-eBh-PD-_z53D5-rSYz5ah5Cl3YaxAQKQSP3i1WgnIQIpoRTERcYlJhVhHdVzFVZSpSFJKKoeEIIsJpahRTIObY-5g9G5U1pXb1krVddQrPdoyBy5SDkJ4Jx6d0mhrjarLwbRbMvsSoTy0W_5p1zP8yFjv7dfKlBs9mt4_9A_0DQYlewQ</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Voronko, O. E.</creator><creator>Dmitrieva-Zdorova, E. V.</creator><creator>Gabaeva, M. V.</creator><creator>Latysheva, E. A.</creator><creator>Storozhakov, G. I.</creator><creator>Lemza, S. V.</creator><creator>Hobrakova, V. B.</creator><creator>Grigorieva, E. V.</creator><creator>Bodoev, N. V.</creator><general>SP MAIK Nauka/Interperiodica</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20110901</creationdate><title>M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma</title><author>Voronko, O. E. ; Dmitrieva-Zdorova, E. V. ; Gabaeva, M. V. ; Latysheva, E. A. ; Storozhakov, G. I. ; Lemza, S. V. ; Hobrakova, V. B. ; Grigorieva, E. V. ; Bodoev, N. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-5e0304e63042dbb3080c34ba5aaa2c16d11f4f5d5d48e4ca7ae906a085a1c3f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animal Genetics and Genomics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Human Genetics</topic><topic>Microbial Genetics and Genomics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voronko, O. E.</creatorcontrib><creatorcontrib>Dmitrieva-Zdorova, E. V.</creatorcontrib><creatorcontrib>Gabaeva, M. V.</creatorcontrib><creatorcontrib>Latysheva, E. A.</creatorcontrib><creatorcontrib>Storozhakov, G. I.</creatorcontrib><creatorcontrib>Lemza, S. V.</creatorcontrib><creatorcontrib>Hobrakova, V. B.</creatorcontrib><creatorcontrib>Grigorieva, E. V.</creatorcontrib><creatorcontrib>Bodoev, N. V.</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Russian journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voronko, O. E.</au><au>Dmitrieva-Zdorova, E. V.</au><au>Gabaeva, M. V.</au><au>Latysheva, E. A.</au><au>Storozhakov, G. I.</au><au>Lemza, S. V.</au><au>Hobrakova, V. B.</au><au>Grigorieva, E. V.</au><au>Bodoev, N. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma</atitle><jtitle>Russian journal of genetics</jtitle><stitle>Russ J Genet</stitle><date>2011-09-01</date><risdate>2011</risdate><volume>47</volume><issue>9</issue><spage>1111</spage><epage>1116</epage><pages>1111-1116</pages><issn>1022-7954</issn><eissn>1608-3369</eissn><abstract>To test the
M31R
and
R335C
polymorphisms of the
Il8RA
gene for association with atopic bronchial asthma (BA), the allele and genotype frequency distributions of the polymorphisms were studied in Russian patients from Moscow and Buryat patients from Ulan-Ude. The study involved two Russian groups, one including 291 DNA samples of patients with atopic BA, and the other, 266 DNA samples of healthy people. The two Buryat groups included 124 and 152 DNA samples from patients with atopic BA and healthy people, respectively. The M31R polymorphism proved to be associated with atopic BA in Russians. Allele
Arg
and genotype
Met/Arg
suggested a higher risk of BA (OR = 4.45,
P
= 0.003 and OR = 4.58,
P
= 0.003, respectively), while allele
Met
and genotype
Met/Met
were associated with a lower risk (OR = 0.22,
P
= 0.003 and OR = 0.22,
P
= 0.003, respectively). The R335C polymorphism was not associated with atopic BA in Russians and was in Buryats. Allele
Arg
and homozygous genotype
Arg/Arg
suggested a higher risk of the disease (OR = 3.06,
P
= 0.030 and OR = 3.20,
P
= 0.027, respectively), while allele
Cys
and genotype
Arg/Cys
suggested a lower risk (OR = 0.33,
P
= 0.030 and OR = 0.31,
P
= 0.027, respectively). The results support the role of the
IL8RA
gene in atopic BA.</abstract><cop>Dordrecht</cop><pub>SP MAIK Nauka/Interperiodica</pub><doi>10.1134/S1022795411090171</doi><tpages>6</tpages></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Human Genetics Microbial Genetics and Genomics |
| title | M31R and R335C polymorphic variants of the IL8RA gene in Russian and Buryat patients with atopic bronchial asthma |
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