Novel FDG-PET Findings in Anti-NMDA Receptor Encephalitis: A Case Based Report
The clinical manifestation and nuclear imaging findings in a 15-year-old boy with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis are described in this case report. The previously healthy patient presented with new onset hallucinations, seizure, and within a week, his mental status rapidly d...
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| Veröffentlicht in: | Journal of Child Neurology 2011-10, Vol.26 (10), p.1325-1328 |
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| container_title | Journal of Child Neurology |
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| creator | Maqbool, Mohsin Oleske, Deanna A. Huq, A. H. M. Salman, Bassel A. Khodabakhsh, Kevin Chugani, Harry T. |
| description | The clinical manifestation and nuclear imaging findings in a 15-year-old boy with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis are described in this case report. The previously healthy patient presented with new onset hallucinations, seizure, and within a week, his mental status rapidly deteriorated to nonverbal with oro-lingual-facial dyskinesias. An extensive laboratory work-up for encephalopathy was negative. Repeated brain magnetic resonance imaging (MRI) studies were normal. On day 26 of admission, nuclear imaging using fluorodeoxyglucose positron emission tomography (FDG-PET) showed global hypometobolism with a prominent focally intense hypermetabolic lesion in the right cerebellar cortex. Diagnosis of anti-NMDAR encephalitis was confirmed with quantitative serology. The patient showed clinical signs of improvement after 2 courses of intravenous immunoglobulin therapy over 4 weeks. On day 46, repeat brain FDG-PET showed overall improvement but in contrast to the previous, the right cerebellar cortex showed focal hypometabolism. This is the first reported case of such findings using FDG-PET in anti-NMDAR encephalitis. |
| doi_str_mv | 10.1177/0883073811405199 |
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H. M. ; Salman, Bassel A. ; Khodabakhsh, Kevin ; Chugani, Harry T.</creator><creatorcontrib>Maqbool, Mohsin ; Oleske, Deanna A. ; Huq, A. H. M. ; Salman, Bassel A. ; Khodabakhsh, Kevin ; Chugani, Harry T.</creatorcontrib><description>The clinical manifestation and nuclear imaging findings in a 15-year-old boy with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis are described in this case report. The previously healthy patient presented with new onset hallucinations, seizure, and within a week, his mental status rapidly deteriorated to nonverbal with oro-lingual-facial dyskinesias. An extensive laboratory work-up for encephalopathy was negative. Repeated brain magnetic resonance imaging (MRI) studies were normal. On day 26 of admission, nuclear imaging using fluorodeoxyglucose positron emission tomography (FDG-PET) showed global hypometobolism with a prominent focally intense hypermetabolic lesion in the right cerebellar cortex. Diagnosis of anti-NMDAR encephalitis was confirmed with quantitative serology. The patient showed clinical signs of improvement after 2 courses of intravenous immunoglobulin therapy over 4 weeks. On day 46, repeat brain FDG-PET showed overall improvement but in contrast to the previous, the right cerebellar cortex showed focal hypometabolism. This is the first reported case of such findings using FDG-PET in anti-NMDAR encephalitis.</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/0883073811405199</identifier><identifier>PMID: 21596699</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adolescent ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnostic imaging ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis - pathology ; Brain ; Case reports ; Cerebellar Cortex - diagnostic imaging ; Cerebellum ; Dyskinesia ; Encephalitis ; Encephalopathy ; Fluorodeoxyglucose F18 ; Glutamic acid receptors ; Hallucinations ; Humans ; Immunoglobulins ; Intravenous administration ; Magnetic Resonance Imaging ; Male ; N-Methyl-D-aspartic acid receptors ; Neuroimaging ; Positron emission tomography ; Seizures ; Serology</subject><ispartof>Journal of Child Neurology, 2011-10, Vol.26 (10), p.1325-1328</ispartof><rights>SAGE Publications 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c321t-2aaedcde50b8ee3026b3b8ab289d0a6b2d40e09bfb4ac33818f2348a55c186ba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0883073811405199$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0883073811405199$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,776,780,788,21798,27899,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21596699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maqbool, Mohsin</creatorcontrib><creatorcontrib>Oleske, Deanna A.</creatorcontrib><creatorcontrib>Huq, A. H. M.</creatorcontrib><creatorcontrib>Salman, Bassel A.</creatorcontrib><creatorcontrib>Khodabakhsh, Kevin</creatorcontrib><creatorcontrib>Chugani, Harry T.</creatorcontrib><title>Novel FDG-PET Findings in Anti-NMDA Receptor Encephalitis: A Case Based Report</title><title>Journal of Child Neurology</title><addtitle>J Child Neurol</addtitle><description>The clinical manifestation and nuclear imaging findings in a 15-year-old boy with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis are described in this case report. The previously healthy patient presented with new onset hallucinations, seizure, and within a week, his mental status rapidly deteriorated to nonverbal with oro-lingual-facial dyskinesias. An extensive laboratory work-up for encephalopathy was negative. Repeated brain magnetic resonance imaging (MRI) studies were normal. On day 26 of admission, nuclear imaging using fluorodeoxyglucose positron emission tomography (FDG-PET) showed global hypometobolism with a prominent focally intense hypermetabolic lesion in the right cerebellar cortex. Diagnosis of anti-NMDAR encephalitis was confirmed with quantitative serology. The patient showed clinical signs of improvement after 2 courses of intravenous immunoglobulin therapy over 4 weeks. On day 46, repeat brain FDG-PET showed overall improvement but in contrast to the previous, the right cerebellar cortex showed focal hypometabolism. 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M. ; Salman, Bassel A. ; Khodabakhsh, Kevin ; Chugani, Harry T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-2aaedcde50b8ee3026b3b8ab289d0a6b2d40e09bfb4ac33818f2348a55c186ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnostic imaging</topic><topic>Anti-N-Methyl-D-Aspartate Receptor Encephalitis - pathology</topic><topic>Brain</topic><topic>Case reports</topic><topic>Cerebellar Cortex - diagnostic imaging</topic><topic>Cerebellum</topic><topic>Dyskinesia</topic><topic>Encephalitis</topic><topic>Encephalopathy</topic><topic>Fluorodeoxyglucose F18</topic><topic>Glutamic acid receptors</topic><topic>Hallucinations</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Intravenous administration</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>N-Methyl-D-aspartic acid receptors</topic><topic>Neuroimaging</topic><topic>Positron emission tomography</topic><topic>Seizures</topic><topic>Serology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maqbool, Mohsin</creatorcontrib><creatorcontrib>Oleske, Deanna A.</creatorcontrib><creatorcontrib>Huq, A. 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| subjects | Adolescent Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnostic imaging Anti-N-Methyl-D-Aspartate Receptor Encephalitis - pathology Brain Case reports Cerebellar Cortex - diagnostic imaging Cerebellum Dyskinesia Encephalitis Encephalopathy Fluorodeoxyglucose F18 Glutamic acid receptors Hallucinations Humans Immunoglobulins Intravenous administration Magnetic Resonance Imaging Male N-Methyl-D-aspartic acid receptors Neuroimaging Positron emission tomography Seizures Serology |
| title | Novel FDG-PET Findings in Anti-NMDA Receptor Encephalitis: A Case Based Report |
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