Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency
► Zinc-deficient rats showed normal memory, while increasing depressive behavior. ► Clioquinol-administered rats showed memory deficit. ► Clioquinol-administered rats did not increase depressive behavior. ► Severe decrease in chelatable zinc may be required for memory deficit. ► The increase in seru...
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| creator | Takeda, Atsushi Tamano, Haruna Ogawa, Taisuke Takada, Shunsuke Ando, Masaki Oku, Naoto Watanabe, Mitsugu |
| description | ► Zinc-deficient rats showed normal memory, while increasing depressive behavior. ► Clioquinol-administered rats showed memory deficit. ► Clioquinol-administered rats did not increase depressive behavior. ► Severe decrease in chelatable zinc may be required for memory deficit. ► The increase in serum glucocorticoid is involved in depression-like behavior.
Dietary zinc deficiency elicits neuropsychological symptoms and cognitive dysfunction. To pursue the mechanisms of these symptoms, in the present study, the relationship among serum glucocorticoid, chelatable zinc in the synaptic cleft and brain function based on behavior was examined in young rats fed a zinc-deficient diet for 4 weeks. Serum glucocorticoid level was significantly increased in zinc-deficient rats. However, the induction of in vivo dentate gyrus LTP and object recognition memory were not affected in zinc-deficient rats. Chelatable zinc levels were decreased in the stratum lucidum of the hippocampal CA3, but not in the molecular layer of the dentate gyrus. It is reported that dentate gyrus LTP and object recognition memory are affected in clioquinol (30
mg/kg)-administered rats, in which chelatable zinc is significantly decreased in the molecular layer of the dentate gyrus. Thus, the significant decrease in chelatable zinc in the molecular layer of the dentate gyrus may be required for object recognition memory deficit in zinc deficiency. On the other hand, the time of grooming in the open-field test was decreased in zinc-deficient rats. Immobility time in the forced swim test was increased in zinc-deficient rats, but not in clioquinol-administered rats, in which chelatable zinc was more markedly decreased than in zinc-deficient rats, suggesting that the lack of chelatable zinc does not increase depression-like behavior. These results suggest that the chronic increase in serum glucocorticoid level is involved in the increase in depression-like behavior rather than the decrease in chelatable zinc after 4-week zinc deficiency. |
| doi_str_mv | 10.1016/j.bbr.2011.09.026 |
| format | Article |
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Dietary zinc deficiency elicits neuropsychological symptoms and cognitive dysfunction. To pursue the mechanisms of these symptoms, in the present study, the relationship among serum glucocorticoid, chelatable zinc in the synaptic cleft and brain function based on behavior was examined in young rats fed a zinc-deficient diet for 4 weeks. Serum glucocorticoid level was significantly increased in zinc-deficient rats. However, the induction of in vivo dentate gyrus LTP and object recognition memory were not affected in zinc-deficient rats. Chelatable zinc levels were decreased in the stratum lucidum of the hippocampal CA3, but not in the molecular layer of the dentate gyrus. It is reported that dentate gyrus LTP and object recognition memory are affected in clioquinol (30
mg/kg)-administered rats, in which chelatable zinc is significantly decreased in the molecular layer of the dentate gyrus. Thus, the significant decrease in chelatable zinc in the molecular layer of the dentate gyrus may be required for object recognition memory deficit in zinc deficiency. On the other hand, the time of grooming in the open-field test was decreased in zinc-deficient rats. Immobility time in the forced swim test was increased in zinc-deficient rats, but not in clioquinol-administered rats, in which chelatable zinc was more markedly decreased than in zinc-deficient rats, suggesting that the lack of chelatable zinc does not increase depression-like behavior. These results suggest that the chronic increase in serum glucocorticoid level is involved in the increase in depression-like behavior rather than the decrease in chelatable zinc after 4-week zinc deficiency.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2011.09.026</identifier><identifier>PMID: 21946308</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult and adolescent clinical studies ; Animals ; Behavior, Animal - physiology ; Behavioral psychophysiology ; Biological and medical sciences ; CA3 Region, Hippocampal - metabolism ; Clioquinol ; Cognition - physiology ; Corticosterone ; Deficiency Diseases - blood ; Deficiency Diseases - complications ; Depression ; Depression - blood ; Depression - complications ; Fundamental and applied biological sciences. Psychology ; Glucocorticoids - blood ; Hippocampus ; Male ; Medical sciences ; Memory ; Mood disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Rats ; Rats, Wistar ; Recognition (Psychology) - physiology ; Zinc - deficiency ; Zinc - metabolism</subject><ispartof>Behavioural brain research, 2012, Vol.226 (1), p.259-264</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-27ec911e60fcfd33065a863cb1d6999765c39fd6ca1c5481ae740c039abcacb3</citedby><cites>FETCH-LOGICAL-c480t-27ec911e60fcfd33065a863cb1d6999765c39fd6ca1c5481ae740c039abcacb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbr.2011.09.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24703897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21946308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeda, Atsushi</creatorcontrib><creatorcontrib>Tamano, Haruna</creatorcontrib><creatorcontrib>Ogawa, Taisuke</creatorcontrib><creatorcontrib>Takada, Shunsuke</creatorcontrib><creatorcontrib>Ando, Masaki</creatorcontrib><creatorcontrib>Oku, Naoto</creatorcontrib><creatorcontrib>Watanabe, Mitsugu</creatorcontrib><title>Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>► Zinc-deficient rats showed normal memory, while increasing depressive behavior. ► Clioquinol-administered rats showed memory deficit. ► Clioquinol-administered rats did not increase depressive behavior. ► Severe decrease in chelatable zinc may be required for memory deficit. ► The increase in serum glucocorticoid is involved in depression-like behavior.
Dietary zinc deficiency elicits neuropsychological symptoms and cognitive dysfunction. To pursue the mechanisms of these symptoms, in the present study, the relationship among serum glucocorticoid, chelatable zinc in the synaptic cleft and brain function based on behavior was examined in young rats fed a zinc-deficient diet for 4 weeks. Serum glucocorticoid level was significantly increased in zinc-deficient rats. However, the induction of in vivo dentate gyrus LTP and object recognition memory were not affected in zinc-deficient rats. Chelatable zinc levels were decreased in the stratum lucidum of the hippocampal CA3, but not in the molecular layer of the dentate gyrus. It is reported that dentate gyrus LTP and object recognition memory are affected in clioquinol (30
mg/kg)-administered rats, in which chelatable zinc is significantly decreased in the molecular layer of the dentate gyrus. Thus, the significant decrease in chelatable zinc in the molecular layer of the dentate gyrus may be required for object recognition memory deficit in zinc deficiency. On the other hand, the time of grooming in the open-field test was decreased in zinc-deficient rats. Immobility time in the forced swim test was increased in zinc-deficient rats, but not in clioquinol-administered rats, in which chelatable zinc was more markedly decreased than in zinc-deficient rats, suggesting that the lack of chelatable zinc does not increase depression-like behavior. These results suggest that the chronic increase in serum glucocorticoid level is involved in the increase in depression-like behavior rather than the decrease in chelatable zinc after 4-week zinc deficiency.</description><subject>Adult and adolescent clinical studies</subject><subject>Animals</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>CA3 Region, Hippocampal - metabolism</subject><subject>Clioquinol</subject><subject>Cognition - physiology</subject><subject>Corticosterone</subject><subject>Deficiency Diseases - blood</subject><subject>Deficiency Diseases - complications</subject><subject>Depression</subject><subject>Depression - blood</subject><subject>Depression - complications</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoids - blood</subject><subject>Hippocampus</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Mood disorders</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recognition (Psychology) - physiology</subject><subject>Zinc - deficiency</subject><subject>Zinc - metabolism</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U1v1DAQBmALgei28AO4oFwQp4TxR5xYnFAFFKkSB3q3nPFk8SobL3aC1P56vN0FboiTZfmZkfW-jL3i0HDg-t2uGYbUCOC8AdOA0E_YhvedqLtWmadsU4yulRT9BbvMeQcAClr-nF0IbpSW0G_Y9lvYzmEM6GakKo5VprTuq-20YsSYloAx-MrNvsLvNLnFDRNVD2HGKsyVp0OinEOcTyKWVcvxVt4ejaeyOdCM9y_Ys9FNmV6ezyt29-nj3fVNffv185frD7c1qh6WWnSEhnPSMOLopQTdul5LHLjXxphOtyjN6DU6jq3quaNOAYI0bkCHg7xib09rDyn-WCkvdh8y0jS5meKarQEhtVG9-A8JWijNZZH8JDHFnBON9pDC3qV7y8Eee7A7W3qwxx4sGFt6KDOvz9vXYU_-z8Tv4At4cwYuo5vGVPIP-a9THcjedMW9Pzkqof0MlGx-DJR8SISL9TH84xu_ACYqpn4</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Takeda, Atsushi</creator><creator>Tamano, Haruna</creator><creator>Ogawa, Taisuke</creator><creator>Takada, Shunsuke</creator><creator>Ando, Masaki</creator><creator>Oku, Naoto</creator><creator>Watanabe, Mitsugu</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>2012</creationdate><title>Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency</title><author>Takeda, Atsushi ; Tamano, Haruna ; Ogawa, Taisuke ; Takada, Shunsuke ; Ando, Masaki ; Oku, Naoto ; Watanabe, Mitsugu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-27ec911e60fcfd33065a863cb1d6999765c39fd6ca1c5481ae740c039abcacb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Animals</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>CA3 Region, Hippocampal - metabolism</topic><topic>Clioquinol</topic><topic>Cognition - physiology</topic><topic>Corticosterone</topic><topic>Deficiency Diseases - blood</topic><topic>Deficiency Diseases - complications</topic><topic>Depression</topic><topic>Depression - blood</topic><topic>Depression - complications</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoids - blood</topic><topic>Hippocampus</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Mood disorders</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recognition (Psychology) - physiology</topic><topic>Zinc - deficiency</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeda, Atsushi</creatorcontrib><creatorcontrib>Tamano, Haruna</creatorcontrib><creatorcontrib>Ogawa, Taisuke</creatorcontrib><creatorcontrib>Takada, Shunsuke</creatorcontrib><creatorcontrib>Ando, Masaki</creatorcontrib><creatorcontrib>Oku, Naoto</creatorcontrib><creatorcontrib>Watanabe, Mitsugu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeda, Atsushi</au><au>Tamano, Haruna</au><au>Ogawa, Taisuke</au><au>Takada, Shunsuke</au><au>Ando, Masaki</au><au>Oku, Naoto</au><au>Watanabe, Mitsugu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2012</date><risdate>2012</risdate><volume>226</volume><issue>1</issue><spage>259</spage><epage>264</epage><pages>259-264</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>► Zinc-deficient rats showed normal memory, while increasing depressive behavior. ► Clioquinol-administered rats showed memory deficit. ► Clioquinol-administered rats did not increase depressive behavior. ► Severe decrease in chelatable zinc may be required for memory deficit. ► The increase in serum glucocorticoid is involved in depression-like behavior.
Dietary zinc deficiency elicits neuropsychological symptoms and cognitive dysfunction. To pursue the mechanisms of these symptoms, in the present study, the relationship among serum glucocorticoid, chelatable zinc in the synaptic cleft and brain function based on behavior was examined in young rats fed a zinc-deficient diet for 4 weeks. Serum glucocorticoid level was significantly increased in zinc-deficient rats. However, the induction of in vivo dentate gyrus LTP and object recognition memory were not affected in zinc-deficient rats. Chelatable zinc levels were decreased in the stratum lucidum of the hippocampal CA3, but not in the molecular layer of the dentate gyrus. It is reported that dentate gyrus LTP and object recognition memory are affected in clioquinol (30
mg/kg)-administered rats, in which chelatable zinc is significantly decreased in the molecular layer of the dentate gyrus. Thus, the significant decrease in chelatable zinc in the molecular layer of the dentate gyrus may be required for object recognition memory deficit in zinc deficiency. On the other hand, the time of grooming in the open-field test was decreased in zinc-deficient rats. Immobility time in the forced swim test was increased in zinc-deficient rats, but not in clioquinol-administered rats, in which chelatable zinc was more markedly decreased than in zinc-deficient rats, suggesting that the lack of chelatable zinc does not increase depression-like behavior. These results suggest that the chronic increase in serum glucocorticoid level is involved in the increase in depression-like behavior rather than the decrease in chelatable zinc after 4-week zinc deficiency.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>21946308</pmid><doi>10.1016/j.bbr.2011.09.026</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Animals Behavior, Animal - physiology Behavioral psychophysiology Biological and medical sciences CA3 Region, Hippocampal - metabolism Clioquinol Cognition - physiology Corticosterone Deficiency Diseases - blood Deficiency Diseases - complications Depression Depression - blood Depression - complications Fundamental and applied biological sciences. Psychology Glucocorticoids - blood Hippocampus Male Medical sciences Memory Mood disorders Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rats Rats, Wistar Recognition (Psychology) - physiology Zinc - deficiency Zinc - metabolism |
| title | Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency |
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