Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I
In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the s...
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| Veröffentlicht in: | Neurology 2011-09, Vol.77 (11), p.1096-1101 |
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| creator | LENZ, M HÖFFKEN, O STUDE, P LISSEK, S SCHWENKREIS, P REINERSMANN, A FRETTLÖH, J RICHTER, H TEGENTHOFF, M MAIER, C |
| description | In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the somatosensory system of patients with CRPS.
We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively.
We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects.
These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I. |
| doi_str_mv | 10.1212/WNL.0b013e31822e1436 |
| format | Article |
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We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively.
We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects.
These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I.</description><identifier>ISSN: 0028-3878</identifier><identifier>EISSN: 1526-632X</identifier><identifier>DOI: 10.1212/WNL.0b013e31822e1436</identifier><identifier>PMID: 21880999</identifier><identifier>CODEN: NEURAI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Electric Stimulation - methods ; Evoked Potentials, Somatosensory - physiology ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neural Inhibition - physiology ; Neurology ; Reflex Sympathetic Dystrophy - diagnosis ; Reflex Sympathetic Dystrophy - physiopathology ; Somatosensory Cortex - physiopathology ; Young Adult</subject><ispartof>Neurology, 2011-09, Vol.77 (11), p.1096-1101</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-c54c6485637dc15c7e717cdf93448cc3c4f469d90a2ea3ca62b45fec5135acd93</citedby><cites>FETCH-LOGICAL-c368t-c54c6485637dc15c7e717cdf93448cc3c4f469d90a2ea3ca62b45fec5135acd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24523527$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21880999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LENZ, M</creatorcontrib><creatorcontrib>HÖFFKEN, O</creatorcontrib><creatorcontrib>STUDE, P</creatorcontrib><creatorcontrib>LISSEK, S</creatorcontrib><creatorcontrib>SCHWENKREIS, P</creatorcontrib><creatorcontrib>REINERSMANN, A</creatorcontrib><creatorcontrib>FRETTLÖH, J</creatorcontrib><creatorcontrib>RICHTER, H</creatorcontrib><creatorcontrib>TEGENTHOFF, M</creatorcontrib><creatorcontrib>MAIER, C</creatorcontrib><title>Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I</title><title>Neurology</title><addtitle>Neurology</addtitle><description>In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the somatosensory system of patients with CRPS.
We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively.
We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects.
These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Electric Stimulation - methods</subject><subject>Evoked Potentials, Somatosensory - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neural Inhibition - physiology</subject><subject>Neurology</subject><subject>Reflex Sympathetic Dystrophy - diagnosis</subject><subject>Reflex Sympathetic Dystrophy - physiopathology</subject><subject>Somatosensory Cortex - physiopathology</subject><subject>Young Adult</subject><issn>0028-3878</issn><issn>1526-632X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9r20AQxZfS0Dhuv0EJupSclOx_7R5TkzYG01xi2ptYj0bNBkmr7MoQf_ussZNALz0NvPd7M_CGkK-MXjLO-NXvX6tLuqFMoGCGc2RS6A9kxhTXpRb8z0cyo5SbUpjKnJKzlB4pzWZlP5FTzoyh1toZWX_3nZswuq5IoXdTSDikEHcFhDjhc9H45IcHv_GTD0Phh6z3Y5eNiH-zkmOjy2raDU0MPRbTbsRi-ZmctK5L-OU452T94-Z-cVuu7n4uF9erEoQ2UwlKgpZGaVE1wBRUWLEKmtYKKQ2AANlKbRtLHUcnwGm-kapFUEwoB40Vc3Jx2DvG8LTFNNW9T4Bd5wYM21RbyoVWipr_ksZYKbWu9qQ8kBBDShHbeoy-d3FXM1rvm69z8_W_zefY-fHAdtNj8xZ6rToD346AS-C6NroBfHrnpOIiv0e8APivjfM</recordid><startdate>20110913</startdate><enddate>20110913</enddate><creator>LENZ, M</creator><creator>HÖFFKEN, O</creator><creator>STUDE, P</creator><creator>LISSEK, S</creator><creator>SCHWENKREIS, P</creator><creator>REINERSMANN, A</creator><creator>FRETTLÖH, J</creator><creator>RICHTER, H</creator><creator>TEGENTHOFF, M</creator><creator>MAIER, C</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110913</creationdate><title>Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I</title><author>LENZ, M ; HÖFFKEN, O ; STUDE, P ; LISSEK, S ; SCHWENKREIS, P ; REINERSMANN, A ; FRETTLÖH, J ; RICHTER, H ; TEGENTHOFF, M ; MAIER, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-c54c6485637dc15c7e717cdf93448cc3c4f469d90a2ea3ca62b45fec5135acd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Electric Stimulation - methods</topic><topic>Evoked Potentials, Somatosensory - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neural Inhibition - physiology</topic><topic>Neurology</topic><topic>Reflex Sympathetic Dystrophy - diagnosis</topic><topic>Reflex Sympathetic Dystrophy - physiopathology</topic><topic>Somatosensory Cortex - physiopathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LENZ, M</creatorcontrib><creatorcontrib>HÖFFKEN, O</creatorcontrib><creatorcontrib>STUDE, P</creatorcontrib><creatorcontrib>LISSEK, S</creatorcontrib><creatorcontrib>SCHWENKREIS, P</creatorcontrib><creatorcontrib>REINERSMANN, A</creatorcontrib><creatorcontrib>FRETTLÖH, J</creatorcontrib><creatorcontrib>RICHTER, H</creatorcontrib><creatorcontrib>TEGENTHOFF, M</creatorcontrib><creatorcontrib>MAIER, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LENZ, M</au><au>HÖFFKEN, O</au><au>STUDE, P</au><au>LISSEK, S</au><au>SCHWENKREIS, P</au><au>REINERSMANN, A</au><au>FRETTLÖH, J</au><au>RICHTER, H</au><au>TEGENTHOFF, M</au><au>MAIER, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I</atitle><jtitle>Neurology</jtitle><addtitle>Neurology</addtitle><date>2011-09-13</date><risdate>2011</risdate><volume>77</volume><issue>11</issue><spage>1096</spage><epage>1101</epage><pages>1096-1101</pages><issn>0028-3878</issn><eissn>1526-632X</eissn><coden>NEURAI</coden><abstract>In a previous study, we found bilateral disinhibition in the motor cortex of patients with complex regional pain syndrome (CRPS). This finding suggests a complex dysfunction of central motor-sensory circuits. The aim of our present study was to assess possible bilateral excitability changes in the somatosensory system of patients with CRPS.
We measured paired-pulse suppression of somatosensory evoked potentials in 21 patients with unilateral CRPS I involving the hand. Eleven patients with upper limb pain of non-neuropathic origin and 21 healthy subjects served as controls. Innocuous paired-pulse stimulation of the median nerve was either performed at the affected and the unaffected hand, or at the dominant hand of healthy controls, respectively.
We found a significant reduction of paired-pulse suppression in both sides of patients with CRPS, compared with control patients and healthy control subjects.
These findings resemble our findings in the motor system and strongly support the hypothesis of a bilateral complex impairment of central motor-sensory circuits in CRPS I.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>21880999</pmid><doi>10.1212/WNL.0b013e31822e1436</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Electric Stimulation - methods Evoked Potentials, Somatosensory - physiology Female Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neural Inhibition - physiology Neurology Reflex Sympathetic Dystrophy - diagnosis Reflex Sympathetic Dystrophy - physiopathology Somatosensory Cortex - physiopathology Young Adult |
| title | Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I |
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