The type I interferon response bridles rabies virus infection and reduces pathogenicity

Rabies virus (RABV) is a neurotropic virus transmitted by the bite of an infected animal that triggers a fatal encephalomyelitis. During its migration in the nervous system (NS), RABV triggers an innate immune response, including a type I IFN response well known to limit viral infections. We showed...

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Veröffentlicht in:	Journal of neurovirology 2011-08, Vol.17 (4), p.353-367
Hauptverfasser:	Chopy, Damien, Detje, Claudia N., Lafage, Mireille, Kalinke, Ulrich, Lafon, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cell Line, Tumor Female Flow Cytometry Humans Immunohistochemistry Immunology Infectious Diseases Injections, Intramuscular Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - metabolism Interferon Type I - biosynthesis Interferon Type I - immunology Interferon Type I - pharmacology Mice Mice, Knockout Neuroblastoma - immunology Neuroblastoma - pathology Neuroblastoma - virology Neurology Neurons - immunology Neurons - virology Neurosciences Primary Cell Culture Rabies - immunology Rabies - mortality Rabies - pathology Rabies - virology Rabies virus Rabies virus - physiology Real-Time Polymerase Chain Reaction Receptor, Interferon alpha-beta - deficiency Receptor, Interferon alpha-beta - genetics Receptor, Interferon alpha-beta - immunology Signal Transduction - immunology Spinal Cord - immunology Spinal Cord - virology STAT2 Transcription Factor - genetics STAT2 Transcription Factor - metabolism Survival Rate Viral Load - immunology Virology
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