Drug-Induced Taste and Smell Alterations: A Case/Non-Case Evaluation of an Italian Database of Spontaneous Adverse Drug Reaction Reporting
Background: The frequency and clinical features of drug-related taste and/or smell impairments are currently unclear. Objective: The aim of this study was to identify major drug classes associated with taste and smell alterations reported to the Italian spontaneous adverse drug reaction (ADR) report...
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| Veröffentlicht in: | Drug safety 2011-10, Vol.34 (10), p.849-859 |
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| creator | Tuccori, Marco Lapi, Francesco Testi, Arianna Ruggiero, Elisa Moretti, Ugo Vannacci, Alfredo Bonaiuti, Roberto Antonioli, Luca Fornai, Matteo Giustarini, Giulio Scollo, Carla Corona, Tiberio Ferrazin, Fernanda Sottosanti, Laura Blandizzi, Corrado |
| description | Background:
The frequency and clinical features of drug-related taste and/or smell impairments are currently unclear.
Objective:
The aim of this study was to identify major drug classes associated with taste and smell alterations reported to the Italian spontaneous adverse drug reaction (ADR) reporting database.
Methods:
The association between drug and altered taste or smell was investigated by case/non-case methodology. The reporting odds ratio (ROR) was used as a measure of disproportionality. Cases were defined as patients with at least one ADR related to taste or smell impairments. The non-cases included all patients without any ADRs related to taste or smell alterations.
Results:
According to the selection criteria, 52 166 reports were included in the analysis. Overall, 182 cases of drug-related taste and/or smell dysfunctions were identified. Statistically significant unadjusted RORs were reported for macrolides (n = 31; 7.1; 95% CI 4.8, 10.5), terbinafine (the only drug reported within the group of antimycotics belonging to the Anatomical Therapeutic Chemical class D01AE) [n=17; 76.4; 95% CI 44.0, 132.6], fluoroquinolones (n= 15; 1.7; 95% CI 1.0, 2.8) and protein kinase inhibitors (n= 10; 4.0; 95% CI 2.1, 7.7). When RORs were adjusted for sex and age category, the disproportion remained statistically significant for all of the previously mentioned drug classes.
Conclusions:
Taste and/or smell abnormalities are common, sometimes unexpected and often persistent complaints of patients during pharmacological treatments. Physicians should be aware of the impact of these ADRs on patients’ quality of life. |
| doi_str_mv | 10.2165/11593120-000000000-00000 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_902363632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A268222782</galeid><sourcerecordid>A268222782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-bb43910712c1cbf6a4180ab5eff55d28fd173c37ab393ba6c60959f64c891e3f3</originalsourceid><addsrcrecordid>eNqFkEtLxDAUhYMoOj7-ghREdNMxN2nSZDn4hgEX6jqkaTJU2lSTduG_N0NnFEEwd5FL8p3LuQehDPCcAGdXAExSIDjH2zN1O2gGUMocZEF20QwDFDmTwA_QYYxvCRCEi310QECUsizlDF3ehHGVP_p6NLbOXnQcbKZ9nT13tm2zRTvYoIem9_EY7TndRnuyuY_Q693ty_VDvny6f7xeLHNDuRjyqiqoBFwCMWAqx3UBAuuKWecYq4lwNZTU0FJXVNJKc8OxZNLxwggJljp6hC6mue-h_xhtHFTXRJPMaG_7MSqJCeWpSCLPJnKlW6sa7_ohaLOm1SKtSQgpxZqa_0Glqm3XmN5b16T3XwIxCUzoYwzWqffQdDp8KsBqnb7apq--05-6JD3deB-rztbfwm3cCTjfADoa3bqgvWniD1cwoJixxMmJi-nLr2xQb_0YfMr9fxNfMUGZKQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>902363632</pqid></control><display><type>article</type><title>Drug-Induced Taste and Smell Alterations: A Case/Non-Case Evaluation of an Italian Database of Spontaneous Adverse Drug Reaction Reporting</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Tuccori, Marco ; Lapi, Francesco ; Testi, Arianna ; Ruggiero, Elisa ; Moretti, Ugo ; Vannacci, Alfredo ; Bonaiuti, Roberto ; Antonioli, Luca ; Fornai, Matteo ; Giustarini, Giulio ; Scollo, Carla ; Corona, Tiberio ; Ferrazin, Fernanda ; Sottosanti, Laura ; Blandizzi, Corrado</creator><creatorcontrib>Tuccori, Marco ; Lapi, Francesco ; Testi, Arianna ; Ruggiero, Elisa ; Moretti, Ugo ; Vannacci, Alfredo ; Bonaiuti, Roberto ; Antonioli, Luca ; Fornai, Matteo ; Giustarini, Giulio ; Scollo, Carla ; Corona, Tiberio ; Ferrazin, Fernanda ; Sottosanti, Laura ; Blandizzi, Corrado</creatorcontrib><description>Background:
The frequency and clinical features of drug-related taste and/or smell impairments are currently unclear.
Objective:
The aim of this study was to identify major drug classes associated with taste and smell alterations reported to the Italian spontaneous adverse drug reaction (ADR) reporting database.
Methods:
The association between drug and altered taste or smell was investigated by case/non-case methodology. The reporting odds ratio (ROR) was used as a measure of disproportionality. Cases were defined as patients with at least one ADR related to taste or smell impairments. The non-cases included all patients without any ADRs related to taste or smell alterations.
Results:
According to the selection criteria, 52 166 reports were included in the analysis. Overall, 182 cases of drug-related taste and/or smell dysfunctions were identified. Statistically significant unadjusted RORs were reported for macrolides (n = 31; 7.1; 95% CI 4.8, 10.5), terbinafine (the only drug reported within the group of antimycotics belonging to the Anatomical Therapeutic Chemical class D01AE) [n=17; 76.4; 95% CI 44.0, 132.6], fluoroquinolones (n= 15; 1.7; 95% CI 1.0, 2.8) and protein kinase inhibitors (n= 10; 4.0; 95% CI 2.1, 7.7). When RORs were adjusted for sex and age category, the disproportion remained statistically significant for all of the previously mentioned drug classes.
Conclusions:
Taste and/or smell abnormalities are common, sometimes unexpected and often persistent complaints of patients during pharmacological treatments. Physicians should be aware of the impact of these ADRs on patients’ quality of life.</description><identifier>ISSN: 0114-5916</identifier><identifier>EISSN: 1179-1942</identifier><identifier>DOI: 10.2165/11593120-000000000-00000</identifier><identifier>PMID: 21879779</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adult ; Adverse and side effects ; Adverse Drug Reaction Reporting Systems ; Age ; Aged ; Biological and medical sciences ; Case-Control Studies ; Databases, Factual ; Drug Safety and Pharmacovigilance ; Drug toxicity and drugs side effects treatment ; Drug-Related Side Effects and Adverse Reactions ; Drugs ; Female ; Fluoroquinolones ; Humans ; Italy ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Odds Ratio ; Olfaction ; Olfaction Disorders - chemically induced ; Original Research Article ; Pharmacology. Drug treatments ; Pharmacology/Toxicology ; protein kinase inhibitors ; Proteins ; Quality of life ; Risk factors ; Side effects ; Smell - drug effects ; Smell disorders ; Statistical analysis ; Taste ; Taste - drug effects ; Taste disorders ; Taste Disorders - chemically induced ; Terbinafine</subject><ispartof>Drug safety, 2011-10, Vol.34 (10), p.849-859</ispartof><rights>Adis Data Information BV 2011</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2011 Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c368t-bb43910712c1cbf6a4180ab5eff55d28fd173c37ab393ba6c60959f64c891e3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.2165/11593120-000000000-00000$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.2165/11593120-000000000-00000$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24513055$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21879779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuccori, Marco</creatorcontrib><creatorcontrib>Lapi, Francesco</creatorcontrib><creatorcontrib>Testi, Arianna</creatorcontrib><creatorcontrib>Ruggiero, Elisa</creatorcontrib><creatorcontrib>Moretti, Ugo</creatorcontrib><creatorcontrib>Vannacci, Alfredo</creatorcontrib><creatorcontrib>Bonaiuti, Roberto</creatorcontrib><creatorcontrib>Antonioli, Luca</creatorcontrib><creatorcontrib>Fornai, Matteo</creatorcontrib><creatorcontrib>Giustarini, Giulio</creatorcontrib><creatorcontrib>Scollo, Carla</creatorcontrib><creatorcontrib>Corona, Tiberio</creatorcontrib><creatorcontrib>Ferrazin, Fernanda</creatorcontrib><creatorcontrib>Sottosanti, Laura</creatorcontrib><creatorcontrib>Blandizzi, Corrado</creatorcontrib><title>Drug-Induced Taste and Smell Alterations: A Case/Non-Case Evaluation of an Italian Database of Spontaneous Adverse Drug Reaction Reporting</title><title>Drug safety</title><addtitle>Drug-Safety</addtitle><addtitle>Drug Saf</addtitle><description>Background:
The frequency and clinical features of drug-related taste and/or smell impairments are currently unclear.
Objective:
The aim of this study was to identify major drug classes associated with taste and smell alterations reported to the Italian spontaneous adverse drug reaction (ADR) reporting database.
Methods:
The association between drug and altered taste or smell was investigated by case/non-case methodology. The reporting odds ratio (ROR) was used as a measure of disproportionality. Cases were defined as patients with at least one ADR related to taste or smell impairments. The non-cases included all patients without any ADRs related to taste or smell alterations.
Results:
According to the selection criteria, 52 166 reports were included in the analysis. Overall, 182 cases of drug-related taste and/or smell dysfunctions were identified. Statistically significant unadjusted RORs were reported for macrolides (n = 31; 7.1; 95% CI 4.8, 10.5), terbinafine (the only drug reported within the group of antimycotics belonging to the Anatomical Therapeutic Chemical class D01AE) [n=17; 76.4; 95% CI 44.0, 132.6], fluoroquinolones (n= 15; 1.7; 95% CI 1.0, 2.8) and protein kinase inhibitors (n= 10; 4.0; 95% CI 2.1, 7.7). When RORs were adjusted for sex and age category, the disproportion remained statistically significant for all of the previously mentioned drug classes.
Conclusions:
Taste and/or smell abnormalities are common, sometimes unexpected and often persistent complaints of patients during pharmacological treatments. Physicians should be aware of the impact of these ADRs on patients’ quality of life.</description><subject>Adult</subject><subject>Adverse and side effects</subject><subject>Adverse Drug Reaction Reporting Systems</subject><subject>Age</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Databases, Factual</subject><subject>Drug Safety and Pharmacovigilance</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Drugs</subject><subject>Female</subject><subject>Fluoroquinolones</subject><subject>Humans</subject><subject>Italy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Odds Ratio</subject><subject>Olfaction</subject><subject>Olfaction Disorders - chemically induced</subject><subject>Original Research Article</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacology/Toxicology</subject><subject>protein kinase inhibitors</subject><subject>Proteins</subject><subject>Quality of life</subject><subject>Risk factors</subject><subject>Side effects</subject><subject>Smell - drug effects</subject><subject>Smell disorders</subject><subject>Statistical analysis</subject><subject>Taste</subject><subject>Taste - drug effects</subject><subject>Taste disorders</subject><subject>Taste Disorders - chemically induced</subject><subject>Terbinafine</subject><issn>0114-5916</issn><issn>1179-1942</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoOj7-ghREdNMxN2nSZDn4hgEX6jqkaTJU2lSTduG_N0NnFEEwd5FL8p3LuQehDPCcAGdXAExSIDjH2zN1O2gGUMocZEF20QwDFDmTwA_QYYxvCRCEi310QECUsizlDF3ehHGVP_p6NLbOXnQcbKZ9nT13tm2zRTvYoIem9_EY7TndRnuyuY_Q693ty_VDvny6f7xeLHNDuRjyqiqoBFwCMWAqx3UBAuuKWecYq4lwNZTU0FJXVNJKc8OxZNLxwggJljp6hC6mue-h_xhtHFTXRJPMaG_7MSqJCeWpSCLPJnKlW6sa7_ohaLOm1SKtSQgpxZqa_0Glqm3XmN5b16T3XwIxCUzoYwzWqffQdDp8KsBqnb7apq--05-6JD3deB-rztbfwm3cCTjfADoa3bqgvWniD1cwoJixxMmJi-nLr2xQb_0YfMr9fxNfMUGZKQ</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Tuccori, Marco</creator><creator>Lapi, Francesco</creator><creator>Testi, Arianna</creator><creator>Ruggiero, Elisa</creator><creator>Moretti, Ugo</creator><creator>Vannacci, Alfredo</creator><creator>Bonaiuti, Roberto</creator><creator>Antonioli, Luca</creator><creator>Fornai, Matteo</creator><creator>Giustarini, Giulio</creator><creator>Scollo, Carla</creator><creator>Corona, Tiberio</creator><creator>Ferrazin, Fernanda</creator><creator>Sottosanti, Laura</creator><creator>Blandizzi, Corrado</creator><general>Springer International Publishing</general><general>Adis International</general><general>Wolters Kluwer Health, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7T2</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20111001</creationdate><title>Drug-Induced Taste and Smell Alterations</title><author>Tuccori, Marco ; Lapi, Francesco ; Testi, Arianna ; Ruggiero, Elisa ; Moretti, Ugo ; Vannacci, Alfredo ; Bonaiuti, Roberto ; Antonioli, Luca ; Fornai, Matteo ; Giustarini, Giulio ; Scollo, Carla ; Corona, Tiberio ; Ferrazin, Fernanda ; Sottosanti, Laura ; Blandizzi, Corrado</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-bb43910712c1cbf6a4180ab5eff55d28fd173c37ab393ba6c60959f64c891e3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adverse and side effects</topic><topic>Adverse Drug Reaction Reporting Systems</topic><topic>Age</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Databases, Factual</topic><topic>Drug Safety and Pharmacovigilance</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Drugs</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Humans</topic><topic>Italy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Odds Ratio</topic><topic>Olfaction</topic><topic>Olfaction Disorders - chemically induced</topic><topic>Original Research Article</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacology/Toxicology</topic><topic>protein kinase inhibitors</topic><topic>Proteins</topic><topic>Quality of life</topic><topic>Risk factors</topic><topic>Side effects</topic><topic>Smell - drug effects</topic><topic>Smell disorders</topic><topic>Statistical analysis</topic><topic>Taste</topic><topic>Taste - drug effects</topic><topic>Taste disorders</topic><topic>Taste Disorders - chemically induced</topic><topic>Terbinafine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuccori, Marco</creatorcontrib><creatorcontrib>Lapi, Francesco</creatorcontrib><creatorcontrib>Testi, Arianna</creatorcontrib><creatorcontrib>Ruggiero, Elisa</creatorcontrib><creatorcontrib>Moretti, Ugo</creatorcontrib><creatorcontrib>Vannacci, Alfredo</creatorcontrib><creatorcontrib>Bonaiuti, Roberto</creatorcontrib><creatorcontrib>Antonioli, Luca</creatorcontrib><creatorcontrib>Fornai, Matteo</creatorcontrib><creatorcontrib>Giustarini, Giulio</creatorcontrib><creatorcontrib>Scollo, Carla</creatorcontrib><creatorcontrib>Corona, Tiberio</creatorcontrib><creatorcontrib>Ferrazin, Fernanda</creatorcontrib><creatorcontrib>Sottosanti, Laura</creatorcontrib><creatorcontrib>Blandizzi, Corrado</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Drug safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuccori, Marco</au><au>Lapi, Francesco</au><au>Testi, Arianna</au><au>Ruggiero, Elisa</au><au>Moretti, Ugo</au><au>Vannacci, Alfredo</au><au>Bonaiuti, Roberto</au><au>Antonioli, Luca</au><au>Fornai, Matteo</au><au>Giustarini, Giulio</au><au>Scollo, Carla</au><au>Corona, Tiberio</au><au>Ferrazin, Fernanda</au><au>Sottosanti, Laura</au><au>Blandizzi, Corrado</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug-Induced Taste and Smell Alterations: A Case/Non-Case Evaluation of an Italian Database of Spontaneous Adverse Drug Reaction Reporting</atitle><jtitle>Drug safety</jtitle><stitle>Drug-Safety</stitle><addtitle>Drug Saf</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>34</volume><issue>10</issue><spage>849</spage><epage>859</epage><pages>849-859</pages><issn>0114-5916</issn><eissn>1179-1942</eissn><abstract>Background:
The frequency and clinical features of drug-related taste and/or smell impairments are currently unclear.
Objective:
The aim of this study was to identify major drug classes associated with taste and smell alterations reported to the Italian spontaneous adverse drug reaction (ADR) reporting database.
Methods:
The association between drug and altered taste or smell was investigated by case/non-case methodology. The reporting odds ratio (ROR) was used as a measure of disproportionality. Cases were defined as patients with at least one ADR related to taste or smell impairments. The non-cases included all patients without any ADRs related to taste or smell alterations.
Results:
According to the selection criteria, 52 166 reports were included in the analysis. Overall, 182 cases of drug-related taste and/or smell dysfunctions were identified. Statistically significant unadjusted RORs were reported for macrolides (n = 31; 7.1; 95% CI 4.8, 10.5), terbinafine (the only drug reported within the group of antimycotics belonging to the Anatomical Therapeutic Chemical class D01AE) [n=17; 76.4; 95% CI 44.0, 132.6], fluoroquinolones (n= 15; 1.7; 95% CI 1.0, 2.8) and protein kinase inhibitors (n= 10; 4.0; 95% CI 2.1, 7.7). When RORs were adjusted for sex and age category, the disproportion remained statistically significant for all of the previously mentioned drug classes.
Conclusions:
Taste and/or smell abnormalities are common, sometimes unexpected and often persistent complaints of patients during pharmacological treatments. Physicians should be aware of the impact of these ADRs on patients’ quality of life.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>21879779</pmid><doi>10.2165/11593120-000000000-00000</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0114-5916 |
| ispartof | Drug safety, 2011-10, Vol.34 (10), p.849-859 |
| issn | 0114-5916 1179-1942 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902363632 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Adverse and side effects Adverse Drug Reaction Reporting Systems Age Aged Biological and medical sciences Case-Control Studies Databases, Factual Drug Safety and Pharmacovigilance Drug toxicity and drugs side effects treatment Drug-Related Side Effects and Adverse Reactions Drugs Female Fluoroquinolones Humans Italy Male Medical sciences Medicine Medicine & Public Health Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Odds Ratio Olfaction Olfaction Disorders - chemically induced Original Research Article Pharmacology. Drug treatments Pharmacology/Toxicology protein kinase inhibitors Proteins Quality of life Risk factors Side effects Smell - drug effects Smell disorders Statistical analysis Taste Taste - drug effects Taste disorders Taste Disorders - chemically induced Terbinafine |
| title | Drug-Induced Taste and Smell Alterations: A Case/Non-Case Evaluation of an Italian Database of Spontaneous Adverse Drug Reaction Reporting |
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