Protection against Paracoccidioides brasiliensis infection conferred by the prophylactic administration of native and recombinant ArtinM

We determined the prophylactic effect of both the d-mannose-binding lectin ArtinM extracted from the seeds of Artocarpus integrifolia (jackfruit) and its recombinant counterpart during the course of experimental paracoccidioidomycosis induced in BALB/c mice. Four experimental protocols of prophylaxi...

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Veröffentlicht in:	Medical mycology (Oxford) 2010-09, Vol.48 (6), p.792-799
Hauptverfasser:	Coltri, Kely C., Oliveira, Leandro L., Ruas, Luciana P., Vendruscolo, Patrícia E., Goldman, Maria Helena, Panunto-Castelo, Ademilson, Roque-Barreira, Maria-Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antifungal Agents - isolation & purification Antifungal Agents - therapeutic use Artocarpus - chemistry Artocarpus integrifolia Chemoprevention - methods Cytokines - analysis Disease Models, Animal Female gamma -Interferon Granuloma Infection Interleukin 10 Interleukin 12 Interleukin 4 Lectins Lectins - isolation & purification Lectins - therapeutic use Lung Lung - immunology Lung - pathology Mice Mice, Inbred BALB C Nitric oxide Nitric Oxide - analysis Paracoccidioides - drug effects Paracoccidioides brasiliensis Paracoccidioidomycosis - immunology Paracoccidioidomycosis - microbiology Paracoccidioidomycosis - pathology Paracoccidioidomycosis - prevention & control Prophylaxis Recombinant Proteins - genetics Recombinant Proteins - therapeutic use Seeds Seeds - chemistry South American blastomycosis Tumor necrosis factor- alpha
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