$Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model$

Manipulation of the anabolic and catabolic responses with BMP-2 and zoledronic acid in a rat femoral fracture model

Abstract Bone repair involves a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone matrix at the fracture site. It has been reported that the optimal time point for single-dose zoledronic acid (ZA) administration systemically...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2011-10, Vol.49 (4), p.777-782
Hauptverfasser:	Doi, Yuji, Miyazaki, Masashi, Yoshiiwa, Toyomi, Hara, Katsutoshi, Kataoka, Masashi, Tsumura, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anabolic Agents - pharmacology Anabolic Agents - therapeutic use Animals Biological and medical sciences Biomechanical Phenomena - drug effects Bone Morphogenetic Protein 2 - pharmacology Bone Morphogenetic Protein 2 - therapeutic use Bones, joints and connective tissue. Antiinflammatory agents Diphosphonates - pharmacology Diphosphonates - therapeutic use Disease Models, Animal Drug Therapy, Combination Femoral Fractures - diagnostic imaging Femoral Fractures - drug therapy Femoral Fractures - pathology Femoral Fractures - surgery Fundamental and applied biological sciences. Psychology Humans Imidazoles - pharmacology Imidazoles - therapeutic use Injuries of the limb. Injuries of the spine Male Medical sciences Orthopedics Palpation Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Transforming Growth Factor beta - pharmacology Transforming Growth Factor beta - therapeutic use Traumas. Diseases due to physical agents Vertebrates: anatomy and physiology, studies on body, several organs or systems X-Ray Microtomography
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