MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways
► Vitamin D 3 and Seocalcitol as tools in prevention and therapy of mammary gland cancer. ► Seocalcitol markedly prolongs tumor latency. ► MicroPET analysis confirms tumor reduction after treatment with vitamin D 3. ► Vitamin D 3 or Seocalcitol reduce vitamin D 3 metabolism in tumor tissue. ► Crosst...
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| Veröffentlicht in: | Toxicology letters 2011-11, Vol.207 (1), p.60-72 |
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| creator | Macejová, Dana Ondková, Slavomíra Jakubíková, Lucia Mlynarčíková, Alžbeta Scsuková, Soňa Liška, Ján Brtko, Július |
| description | ► Vitamin D
3 and Seocalcitol as tools in prevention and therapy of mammary gland cancer. ► Seocalcitol markedly prolongs tumor latency. ► MicroPET analysis confirms tumor reduction after treatment with vitamin D
3. ► Vitamin D
3 or Seocalcitol reduce vitamin D
3 metabolism in tumor tissue. ► Crosstalk within nuclear receptor regulatory pathways.
The effects of administration of vitamin D
3 and Seocalcitol on MNU-induced carcinogenesis of mammary gland in Sprague-Dawley rats have been investigated. Administration of both substances in a weekly dose of 7
μg/kg caused prolonged latency of mammary gland tumors. The latency of tumors was markedly prolonged for 30–40 days by Seocalcitol. Using PET analysis, reduction in [
18F]2-fluoro-2-deoxy-
d-glucose (FDG) uptake or tumor volume in tumors chemopreventively treated with vitamin D
3 were detected in MNU-induced tumors, vitamin D
3 reduced expression of 25-hydroxylase (25OHase) (
p
<
0.01) and 24-hydroxylase (24OHase) (
p
<
0.01) and Seocalcitol 24OHase. Positive regulation of 25OHase mRNA level after the treatment with vitamin D
3 was observed in liver, while in kidney, vitamin D
3 and Seocalcitol induced expression of 24OHase was significant. Our observations indicate a cross talk between respective pathways of VDR, RARs/RXRs, TRs and ERs in carcinogenesis process. |
| doi_str_mv | 10.1016/j.toxlet.2011.07.029 |
| format | Article |
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3 and Seocalcitol as tools in prevention and therapy of mammary gland cancer. ► Seocalcitol markedly prolongs tumor latency. ► MicroPET analysis confirms tumor reduction after treatment with vitamin D
3. ► Vitamin D
3 or Seocalcitol reduce vitamin D
3 metabolism in tumor tissue. ► Crosstalk within nuclear receptor regulatory pathways.
The effects of administration of vitamin D
3 and Seocalcitol on MNU-induced carcinogenesis of mammary gland in Sprague-Dawley rats have been investigated. Administration of both substances in a weekly dose of 7
μg/kg caused prolonged latency of mammary gland tumors. The latency of tumors was markedly prolonged for 30–40 days by Seocalcitol. Using PET analysis, reduction in [
18F]2-fluoro-2-deoxy-
d-glucose (FDG) uptake or tumor volume in tumors chemopreventively treated with vitamin D
3 were detected in MNU-induced tumors, vitamin D
3 reduced expression of 25-hydroxylase (25OHase) (
p
<
0.01) and 24-hydroxylase (24OHase) (
p
<
0.01) and Seocalcitol 24OHase. Positive regulation of 25OHase mRNA level after the treatment with vitamin D
3 was observed in liver, while in kidney, vitamin D
3 and Seocalcitol induced expression of 24OHase was significant. Our observations indicate a cross talk between respective pathways of VDR, RARs/RXRs, TRs and ERs in carcinogenesis process.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2011.07.029</identifier><identifier>PMID: 21843606</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Calcitriol - analogs & derivatives ; Calcitriol - pharmacology ; Carcinogenesis, carcinogens and anticarcinogens ; Cell Transformation, Neoplastic - chemically induced ; Cell Transformation, Neoplastic - drug effects ; Chemical agents ; Cholecalciferol - pharmacology ; Female ; Gynecology. Andrology. Obstetrics ; Histocytochemistry ; Hydroxylase ; Mammary gland diseases ; Mammary Neoplasms, Experimental - chemically induced ; Mammary Neoplasms, Experimental - enzymology ; Mammary Neoplasms, Experimental - metabolism ; Mammary Neoplasms, Experimental - prevention & control ; Medical sciences ; Methylnitrosourea - toxicity ; Mixed Function Oxygenases - genetics ; Mixed Function Oxygenases - metabolism ; MNU-induced mammary gland tumors ; Nuclear receptors ; Positron-Emission Tomography ; Rats ; Rats, Sprague-Dawley ; Receptors, Calcitriol - genetics ; Receptors, Calcitriol - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; Seocalcitol (EB1089) ; Tumors ; Vitamin D</subject><ispartof>Toxicology letters, 2011-11, Vol.207 (1), p.60-72</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-e30c942e446ca4dcd23f097e3eee7ff3a55dab40a0b5982ed7712698c149478a3</citedby><cites>FETCH-LOGICAL-c423t-e30c942e446ca4dcd23f097e3eee7ff3a55dab40a0b5982ed7712698c149478a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378427411014743$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24604452$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21843606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Macejová, Dana</creatorcontrib><creatorcontrib>Ondková, Slavomíra</creatorcontrib><creatorcontrib>Jakubíková, Lucia</creatorcontrib><creatorcontrib>Mlynarčíková, Alžbeta</creatorcontrib><creatorcontrib>Scsuková, Soňa</creatorcontrib><creatorcontrib>Liška, Ján</creatorcontrib><creatorcontrib>Brtko, Július</creatorcontrib><title>MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>► Vitamin D
3 and Seocalcitol as tools in prevention and therapy of mammary gland cancer. ► Seocalcitol markedly prolongs tumor latency. ► MicroPET analysis confirms tumor reduction after treatment with vitamin D
3. ► Vitamin D
3 or Seocalcitol reduce vitamin D
3 metabolism in tumor tissue. ► Crosstalk within nuclear receptor regulatory pathways.
The effects of administration of vitamin D
3 and Seocalcitol on MNU-induced carcinogenesis of mammary gland in Sprague-Dawley rats have been investigated. Administration of both substances in a weekly dose of 7
μg/kg caused prolonged latency of mammary gland tumors. The latency of tumors was markedly prolonged for 30–40 days by Seocalcitol. Using PET analysis, reduction in [
18F]2-fluoro-2-deoxy-
d-glucose (FDG) uptake or tumor volume in tumors chemopreventively treated with vitamin D
3 were detected in MNU-induced tumors, vitamin D
3 reduced expression of 25-hydroxylase (25OHase) (
p
<
0.01) and 24-hydroxylase (24OHase) (
p
<
0.01) and Seocalcitol 24OHase. Positive regulation of 25OHase mRNA level after the treatment with vitamin D
3 was observed in liver, while in kidney, vitamin D
3 and Seocalcitol induced expression of 24OHase was significant. Our observations indicate a cross talk between respective pathways of VDR, RARs/RXRs, TRs and ERs in carcinogenesis process.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcitriol - analogs & derivatives</subject><subject>Calcitriol - pharmacology</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Cell Transformation, Neoplastic - chemically induced</subject><subject>Cell Transformation, Neoplastic - drug effects</subject><subject>Chemical agents</subject><subject>Cholecalciferol - pharmacology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Histocytochemistry</subject><subject>Hydroxylase</subject><subject>Mammary gland diseases</subject><subject>Mammary Neoplasms, Experimental - chemically induced</subject><subject>Mammary Neoplasms, Experimental - enzymology</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mammary Neoplasms, Experimental - prevention & control</subject><subject>Medical sciences</subject><subject>Methylnitrosourea - toxicity</subject><subject>Mixed Function Oxygenases - genetics</subject><subject>Mixed Function Oxygenases - metabolism</subject><subject>MNU-induced mammary gland tumors</subject><subject>Nuclear receptors</subject><subject>Positron-Emission Tomography</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Calcitriol - genetics</subject><subject>Receptors, Calcitriol - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><subject>Seocalcitol (EB1089)</subject><subject>Tumors</subject><subject>Vitamin D</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2O0zAUhS0EYsrAGyDkDWKVcP2TOGGBNCq_0gALmLXlOjetqyQOtlOYx-FNcWlhdqwsWd_xsc5HyFMGJQNWv9yXyf8cMJUcGCtBlcDbe2TFGtUWgtXtfbICoZpCciUvyKMY9wBQy7p6SC44a6SooV6RX58-3xRu6haLHR3NOJpwS7eDmTpqTbBu8lucMLr4iq53OPo54AGn5A5Ij0zaYTAzLslZin2PNkXqe3pwyYxuom_-QF_RWzNYl_xA_UQjDpnLdQG3y2CSz413gYAW53xHZ5N2P8xtfEwe9GaI-OR8XpKbd2-_rT8U11_ef1xfXRdWcpEKFGBbyVHK2hrZ2Y6LHlqFAhFV3wtTVZ3ZSDCwqdqGY6cU43XbWCZbqRojLsmL07tz8N8XjEmPLloc8hbol6hb4KJquIBMyhNpg48xYK_n4I7DaQb66Ebv9cmNPrrRoHR2k2PPzgXLZsTuX-ivjAw8PwMm5sH6YCbr4h0na5Cy4pl7feIwz3FwGHS0Dqds0OX1ku68-_9PfgPEFLMl</recordid><startdate>20111110</startdate><enddate>20111110</enddate><creator>Macejová, Dana</creator><creator>Ondková, Slavomíra</creator><creator>Jakubíková, Lucia</creator><creator>Mlynarčíková, Alžbeta</creator><creator>Scsuková, Soňa</creator><creator>Liška, Ján</creator><creator>Brtko, Július</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20111110</creationdate><title>MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways</title><author>Macejová, Dana ; Ondková, Slavomíra ; Jakubíková, Lucia ; Mlynarčíková, Alžbeta ; Scsuková, Soňa ; Liška, Ján ; Brtko, Július</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-e30c942e446ca4dcd23f097e3eee7ff3a55dab40a0b5982ed7712698c149478a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcitriol - analogs & derivatives</topic><topic>Calcitriol - pharmacology</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Cell Transformation, Neoplastic - chemically induced</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Chemical agents</topic><topic>Cholecalciferol - pharmacology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Histocytochemistry</topic><topic>Hydroxylase</topic><topic>Mammary gland diseases</topic><topic>Mammary Neoplasms, Experimental - chemically induced</topic><topic>Mammary Neoplasms, Experimental - enzymology</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Mammary Neoplasms, Experimental - prevention & control</topic><topic>Medical sciences</topic><topic>Methylnitrosourea - toxicity</topic><topic>Mixed Function Oxygenases - genetics</topic><topic>Mixed Function Oxygenases - metabolism</topic><topic>MNU-induced mammary gland tumors</topic><topic>Nuclear receptors</topic><topic>Positron-Emission Tomography</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Calcitriol - genetics</topic><topic>Receptors, Calcitriol - metabolism</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>Seocalcitol (EB1089)</topic><topic>Tumors</topic><topic>Vitamin D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Macejová, Dana</creatorcontrib><creatorcontrib>Ondková, Slavomíra</creatorcontrib><creatorcontrib>Jakubíková, Lucia</creatorcontrib><creatorcontrib>Mlynarčíková, Alžbeta</creatorcontrib><creatorcontrib>Scsuková, Soňa</creatorcontrib><creatorcontrib>Liška, Ján</creatorcontrib><creatorcontrib>Brtko, Július</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Macejová, Dana</au><au>Ondková, Slavomíra</au><au>Jakubíková, Lucia</au><au>Mlynarčíková, Alžbeta</au><au>Scsuková, Soňa</au><au>Liška, Ján</au><au>Brtko, Július</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2011-11-10</date><risdate>2011</risdate><volume>207</volume><issue>1</issue><spage>60</spage><epage>72</epage><pages>60-72</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>► Vitamin D
3 and Seocalcitol as tools in prevention and therapy of mammary gland cancer. ► Seocalcitol markedly prolongs tumor latency. ► MicroPET analysis confirms tumor reduction after treatment with vitamin D
3. ► Vitamin D
3 or Seocalcitol reduce vitamin D
3 metabolism in tumor tissue. ► Crosstalk within nuclear receptor regulatory pathways.
The effects of administration of vitamin D
3 and Seocalcitol on MNU-induced carcinogenesis of mammary gland in Sprague-Dawley rats have been investigated. Administration of both substances in a weekly dose of 7
μg/kg caused prolonged latency of mammary gland tumors. The latency of tumors was markedly prolonged for 30–40 days by Seocalcitol. Using PET analysis, reduction in [
18F]2-fluoro-2-deoxy-
d-glucose (FDG) uptake or tumor volume in tumors chemopreventively treated with vitamin D
3 were detected in MNU-induced tumors, vitamin D
3 reduced expression of 25-hydroxylase (25OHase) (
p
<
0.01) and 24-hydroxylase (24OHase) (
p
<
0.01) and Seocalcitol 24OHase. Positive regulation of 25OHase mRNA level after the treatment with vitamin D
3 was observed in liver, while in kidney, vitamin D
3 and Seocalcitol induced expression of 24OHase was significant. Our observations indicate a cross talk between respective pathways of VDR, RARs/RXRs, TRs and ERs in carcinogenesis process.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21843606</pmid><doi>10.1016/j.toxlet.2011.07.029</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2011-11, Vol.207 (1), p.60-72 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902358230 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Calcitriol - analogs & derivatives Calcitriol - pharmacology Carcinogenesis, carcinogens and anticarcinogens Cell Transformation, Neoplastic - chemically induced Cell Transformation, Neoplastic - drug effects Chemical agents Cholecalciferol - pharmacology Female Gynecology. Andrology. Obstetrics Histocytochemistry Hydroxylase Mammary gland diseases Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - enzymology Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - prevention & control Medical sciences Methylnitrosourea - toxicity Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism MNU-induced mammary gland tumors Nuclear receptors Positron-Emission Tomography Rats Rats, Sprague-Dawley Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - chemistry RNA, Messenger - genetics Seocalcitol (EB1089) Tumors Vitamin D |
| title | MNU-induced mammary gland carcinogenesis: Chemopreventive and therapeutic effects of vitamin D and Seocalcitol on selected regulatory vitamin D receptor pathways |
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