Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure
Abstract The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal trans...
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| Veröffentlicht in: | Neurotoxicology and teratology 2011-09, Vol.33 (5), p.598-602 |
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| creator | Win-Shwe, Tin-Tin Kunugita, Naoki Yoshida, Yasuhiro Fujimaki, Hidekazu |
| description | Abstract The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the hippocampi were examined using real-time RT-PCR and an immunohistochemical analysis. In C3H/HeN mice, the relative mRNA expression levels of TLR4 and NF-κB activating protein were significantly up-regulated in the groups exposed to toluene, but not in the C3H/HeJ mice. Heat shock protein 70, a possible endogenous ligand for TLR4, mRNA was increased in the C3H/HeN mice exposed to toluene. This is the first report to show that TLR4 may have a role in the neurotoxic effects in mice exposed to toluene. |
| doi_str_mv | 10.1016/j.ntt.2011.07.005 |
| format | Article |
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Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the hippocampi were examined using real-time RT-PCR and an immunohistochemical analysis. In C3H/HeN mice, the relative mRNA expression levels of TLR4 and NF-κB activating protein were significantly up-regulated in the groups exposed to toluene, but not in the C3H/HeJ mice. Heat shock protein 70, a possible endogenous ligand for TLR4, mRNA was increased in the C3H/HeN mice exposed to toluene. This is the first report to show that TLR4 may have a role in the neurotoxic effects in mice exposed to toluene.</description><identifier>ISSN: 0892-0362</identifier><identifier>EISSN: 1872-9738</identifier><identifier>DOI: 10.1016/j.ntt.2011.07.005</identifier><identifier>PMID: 21802510</identifier><identifier>CODEN: NETEEC</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Inhalation ; Animals ; Biological and medical sciences ; Chemical and industrial products toxicology. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-78eca3f23486670b07a71b826fb70a6d5848dfd454e58e374bdca5d63f05c9b63</citedby><cites>FETCH-LOGICAL-c535t-78eca3f23486670b07a71b826fb70a6d5848dfd454e58e374bdca5d63f05c9b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ntt.2011.07.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24699133$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21802510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Win-Shwe, Tin-Tin</creatorcontrib><creatorcontrib>Kunugita, Naoki</creatorcontrib><creatorcontrib>Yoshida, Yasuhiro</creatorcontrib><creatorcontrib>Fujimaki, Hidekazu</creatorcontrib><title>Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure</title><title>Neurotoxicology and teratology</title><addtitle>Neurotoxicol Teratol</addtitle><description>Abstract The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the hippocampi were examined using real-time RT-PCR and an immunohistochemical analysis. In C3H/HeN mice, the relative mRNA expression levels of TLR4 and NF-κB activating protein were significantly up-regulated in the groups exposed to toluene, but not in the C3H/HeJ mice. Heat shock protein 70, a possible endogenous ligand for TLR4, mRNA was increased in the C3H/HeN mice exposed to toluene. This is the first report to show that TLR4 may have a role in the neurotoxic effects in mice exposed to toluene.</description><subject>Administration, Inhalation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Emergency</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression - genetics</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>HSP70 Heat-Shock Proteins - biosynthesis</subject><subject>Hsp70 protein</subject><subject>Hyaluronic Acid - biosynthesis</subject><subject>Male</subject><subject>Medical Education</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Mutant Strains</subject><subject>Neurotoxicity</subject><subject>Neurotoxicity Syndromes - genetics</subject><subject>Neurotoxicity Syndromes - metabolism</subject><subject>NF- Kappa B protein</subject><subject>NF-kappa B - biosynthesis</subject><subject>Polymerase chain reaction</subject><subject>Signal transduction</subject><subject>Solvents</subject><subject>Solvents - administration & dosage</subject><subject>Solvents - toxicity</subject><subject>TLR4 protein</subject><subject>Toll-like receptor</subject><subject>Toll-Like Receptor 4 - biosynthesis</subject><subject>Toll-Like Receptor 4 - genetics</subject><subject>Toll-like receptors</subject><subject>Toluene</subject><subject>Toluene - administration & dosage</subject><subject>Toluene - toxicity</subject><subject>Toxicology</subject><subject>Up-Regulation - drug effects</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1TAQhoMo7nH1B3gjvRGvWidJ81EEQRa_4ICwrtchTaeaY9rUpNU9_96Wc1TwQq8Cw_POhGeGkMcUKgpUPj9U4zxXDCitQFUA4g7ZUa1Y2Siu75Id6IaVwCW7IA9yPgCAkhTukwtGNTBBYUf21zFgEfvii5-m6Oww2VDc7K_rwo_FiEuKc7z1zs_HrTB4h0UfQ4g__Pi5mGNYcMQCb6eYl4QPyb3ehoyPzu8l-fTm9c3Vu3L_4e37q1f70gku5lJpdJb3jNdaSgUtKKtoq5nsWwVWdkLXuuu7WtQoNHJVt52zopO8B-GaVvJL8uzUd0rx24J5NoPPDkOwI8YlmwYYF5pK-C-pG6EFV1StJD2RLsWcE_ZmSn6w6WgomM22OZjVttlsG1Bmtb1mnpy7L-2A3e_EL70r8PQM2Oxs6JMdnc9_uFo2DeV85V6cOFytffeYTHYeR4edT-hm00X_z2-8_Cvtgh_9OvArHjEf4pLGdR2GmswMmI_bWWxXQSkAFTXlPwGqirDu</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Win-Shwe, Tin-Tin</creator><creator>Kunugita, Naoki</creator><creator>Yoshida, Yasuhiro</creator><creator>Fujimaki, Hidekazu</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20110901</creationdate><title>Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure</title><author>Win-Shwe, Tin-Tin ; Kunugita, Naoki ; Yoshida, Yasuhiro ; Fujimaki, Hidekazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-78eca3f23486670b07a71b826fb70a6d5848dfd454e58e374bdca5d63f05c9b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Administration, Inhalation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Emergency</topic><topic>Gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression - genetics</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>HSP70 Heat-Shock Proteins - biosynthesis</topic><topic>Hsp70 protein</topic><topic>Hyaluronic Acid - biosynthesis</topic><topic>Male</topic><topic>Medical Education</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Mice, Mutant Strains</topic><topic>Neurotoxicity</topic><topic>Neurotoxicity Syndromes - genetics</topic><topic>Neurotoxicity Syndromes - metabolism</topic><topic>NF- Kappa B protein</topic><topic>NF-kappa B - biosynthesis</topic><topic>Polymerase chain reaction</topic><topic>Signal transduction</topic><topic>Solvents</topic><topic>Solvents - administration & dosage</topic><topic>Solvents - toxicity</topic><topic>TLR4 protein</topic><topic>Toll-like receptor</topic><topic>Toll-Like Receptor 4 - biosynthesis</topic><topic>Toll-Like Receptor 4 - genetics</topic><topic>Toll-like receptors</topic><topic>Toluene</topic><topic>Toluene - administration & dosage</topic><topic>Toluene - toxicity</topic><topic>Toxicology</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Win-Shwe, Tin-Tin</creatorcontrib><creatorcontrib>Kunugita, Naoki</creatorcontrib><creatorcontrib>Yoshida, Yasuhiro</creatorcontrib><creatorcontrib>Fujimaki, Hidekazu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Win-Shwe, Tin-Tin</au><au>Kunugita, Naoki</au><au>Yoshida, Yasuhiro</au><au>Fujimaki, Hidekazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>33</volume><issue>5</issue><spage>598</spage><epage>602</epage><pages>598-602</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>Abstract The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the hippocampi were examined using real-time RT-PCR and an immunohistochemical analysis. In C3H/HeN mice, the relative mRNA expression levels of TLR4 and NF-κB activating protein were significantly up-regulated in the groups exposed to toluene, but not in the C3H/HeJ mice. Heat shock protein 70, a possible endogenous ligand for TLR4, mRNA was increased in the C3H/HeN mice exposed to toluene. This is the first report to show that TLR4 may have a role in the neurotoxic effects in mice exposed to toluene.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21802510</pmid><doi>10.1016/j.ntt.2011.07.005</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Inhalation Animals Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Emergency Gene expression Gene Expression - drug effects Gene Expression - genetics Hippocampus Hippocampus - drug effects Hippocampus - metabolism HSP70 Heat-Shock Proteins - biosynthesis Hsp70 protein Hyaluronic Acid - biosynthesis Male Medical Education Medical sciences Mice Mice, Inbred C3H Mice, Mutant Strains Neurotoxicity Neurotoxicity Syndromes - genetics Neurotoxicity Syndromes - metabolism NF- Kappa B protein NF-kappa B - biosynthesis Polymerase chain reaction Signal transduction Solvents Solvents - administration & dosage Solvents - toxicity TLR4 protein Toll-like receptor Toll-Like Receptor 4 - biosynthesis Toll-Like Receptor 4 - genetics Toll-like receptors Toluene Toluene - administration & dosage Toluene - toxicity Toxicology Up-Regulation - drug effects |
| title | Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure |
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