Surface grafting of blood compatible zwitterionic poly(ethylene glycol) on diamond-like carbon-coated stent
Blood compatibility is the most important aspect for blood-contacting medical devices including cardiovascular stents. In this study, the surface of nickel–titanium (TiNi) stent was coated with diamond-like carbon (DLC) and then subsequently grafted by using zwitterion (N + and SO 3 − )-linked poly(...
Gespeichert in:
| Veröffentlicht in: | Journal of materials science. Materials in medicine 2011-03, Vol.22 (3), p.507-514 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 514 |
|---|---|
| container_issue | 3 |
| container_start_page | 507 |
| container_title | Journal of materials science. Materials in medicine |
| container_volume | 22 |
| creator | Lee, Bong Soo Shin, Hong-Sub Park, Kwideok Han, Dong Keun |
| description | Blood compatibility is the most important aspect for blood-contacting medical devices including cardiovascular stents. In this study, the surface of nickel–titanium (TiNi) stent was coated with diamond-like carbon (DLC) and then subsequently grafted by using zwitterion (N
+
and SO
3
−
)-linked poly(ethylene glycol) (PEG). We hypothesize that this coupling of zwitterion and PEG may significantly improve blood compatibility of DLC-coated TiNi stent. The surface modified TiNi stents, including PEG-grafted stent (DLC-PEG) and zwitterionic PEG-grafted one (DLC-PEG-N-S) were the main focus on the tests of surface characteristics and blood compatibility. The zwitterionic PEG derivatives were obtained from a series of chemical reactions at room temperature. The results exhibited that as compared to the DLC-PEG, the hydrophilicity was much better with DLC-PEG-N-S and significantly increased atomic percentage of oxygen and nitrogen proved the entity of zwitterions on the surface of DLC-PEG-N-S. Meanwhile, the adsorption of blood proteins such as, human serum albumin (HSA) and fibrinogen was found considerably down-regulated in DLC-PEG-N-S, due mainly to the protein-repellant effect of PEG and zwitterion. Microscopic observation also revealed that as compared with the other substrates without zwitterion, the degree of platelet adhesion was the lowest with DLC-PEG-N-S. In addition, DLC-PEG-N-S retained an extended blood coagulation time as measured by activated partial thromboplastin time (APTT). The present results suggested that surface grafting of zwitterionic PEG derivatives could substantially enhance the blood compatibility of TiNi-DLC stent. In conclusion, anti-fouling properties of PEG and zwitterions are expected to be very useful in advancing overall stent performance. |
| doi_str_mv | 10.1007/s10856-011-4235-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902350879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902350879</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-fdb74d70c16ba6c5e4a70560f687dfe2470736fe8cceb64217ca5d61d159525d3</originalsourceid><addsrcrecordid>eNqF0cuKFDEUBuAgitMz-gBuJAgyuogmVbnVUgZvMOBCXYdULm1mUkmbpJD26U3TrQOCuMoi3znJOT8ATwh-RTAWryvBknGECUF0GBli98CGMDEiKkd5H2zwxASibMRn4LzWG4wxnRh7CM4GMoiJi2EDbj-vxWvj4LZo30LawuzhHHO20ORlp1uYo4M_f4TWXAk5BQN3Oe5fuPZtH13qdXFvcnwJc4I26CUni2K4ddDoMueETNbNWVibS-0ReOB1rO7x6bwAX9-9_XL1AV1_ev_x6s01MnSSDXk7C2oFNoTPmhvmqBaYcey5FNa7gQosRu6dNMbNnA5EGM0sJ5awiQ3Mjhfg8th3V_L31dWmllCNi1Enl9eqJtyXhaWY_islJ0xyOZIun_0lb_JaUh_jgLCgE5EdkSMyJddanFe7EhZd9opgdUhMHRNTPTF1SEyxXvP01HidF2f_VPyOqIPnJ6Cr0dEXnUyod44SIft6uhuOrvartHXl7of_fv0XLjOuVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>861074918</pqid></control><display><type>article</type><title>Surface grafting of blood compatible zwitterionic poly(ethylene glycol) on diamond-like carbon-coated stent</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Lee, Bong Soo ; Shin, Hong-Sub ; Park, Kwideok ; Han, Dong Keun</creator><creatorcontrib>Lee, Bong Soo ; Shin, Hong-Sub ; Park, Kwideok ; Han, Dong Keun</creatorcontrib><description>Blood compatibility is the most important aspect for blood-contacting medical devices including cardiovascular stents. In this study, the surface of nickel–titanium (TiNi) stent was coated with diamond-like carbon (DLC) and then subsequently grafted by using zwitterion (N
+
and SO
3
−
)-linked poly(ethylene glycol) (PEG). We hypothesize that this coupling of zwitterion and PEG may significantly improve blood compatibility of DLC-coated TiNi stent. The surface modified TiNi stents, including PEG-grafted stent (DLC-PEG) and zwitterionic PEG-grafted one (DLC-PEG-N-S) were the main focus on the tests of surface characteristics and blood compatibility. The zwitterionic PEG derivatives were obtained from a series of chemical reactions at room temperature. The results exhibited that as compared to the DLC-PEG, the hydrophilicity was much better with DLC-PEG-N-S and significantly increased atomic percentage of oxygen and nitrogen proved the entity of zwitterions on the surface of DLC-PEG-N-S. Meanwhile, the adsorption of blood proteins such as, human serum albumin (HSA) and fibrinogen was found considerably down-regulated in DLC-PEG-N-S, due mainly to the protein-repellant effect of PEG and zwitterion. Microscopic observation also revealed that as compared with the other substrates without zwitterion, the degree of platelet adhesion was the lowest with DLC-PEG-N-S. In addition, DLC-PEG-N-S retained an extended blood coagulation time as measured by activated partial thromboplastin time (APTT). The present results suggested that surface grafting of zwitterionic PEG derivatives could substantially enhance the blood compatibility of TiNi-DLC stent. In conclusion, anti-fouling properties of PEG and zwitterions are expected to be very useful in advancing overall stent performance.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-011-4235-5</identifier><identifier>PMID: 21279672</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adsorption ; Biocompatible Materials - chemistry ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Blood Coagulation ; Carbon ; Carbon - chemistry ; Ceramics ; Chemistry and Materials Science ; Coated Materials, Biocompatible - chemistry ; Composites ; Diamond - chemistry ; Fibrinogen - chemistry ; Glass ; Humans ; Ions ; Magnetic Resonance Spectroscopy ; Materials Science ; Medical sciences ; Natural Materials ; Nickel - chemistry ; Partial Thromboplastin Time ; Platelet Adhesiveness ; Polyethylene Glycols - chemistry ; Polymer Sciences ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Regenerative Medicine/Tissue Engineering ; Stents ; Surface chemistry ; Surface Properties ; Surfaces and Interfaces ; Thin Films ; Titanium - chemistry</subject><ispartof>Journal of materials science. Materials in medicine, 2011-03, Vol.22 (3), p.507-514</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-fdb74d70c16ba6c5e4a70560f687dfe2470736fe8cceb64217ca5d61d159525d3</citedby><cites>FETCH-LOGICAL-c498t-fdb74d70c16ba6c5e4a70560f687dfe2470736fe8cceb64217ca5d61d159525d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-011-4235-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-011-4235-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24178056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21279672$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Bong Soo</creatorcontrib><creatorcontrib>Shin, Hong-Sub</creatorcontrib><creatorcontrib>Park, Kwideok</creatorcontrib><creatorcontrib>Han, Dong Keun</creatorcontrib><title>Surface grafting of blood compatible zwitterionic poly(ethylene glycol) on diamond-like carbon-coated stent</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Blood compatibility is the most important aspect for blood-contacting medical devices including cardiovascular stents. In this study, the surface of nickel–titanium (TiNi) stent was coated with diamond-like carbon (DLC) and then subsequently grafted by using zwitterion (N
+
and SO
3
−
)-linked poly(ethylene glycol) (PEG). We hypothesize that this coupling of zwitterion and PEG may significantly improve blood compatibility of DLC-coated TiNi stent. The surface modified TiNi stents, including PEG-grafted stent (DLC-PEG) and zwitterionic PEG-grafted one (DLC-PEG-N-S) were the main focus on the tests of surface characteristics and blood compatibility. The zwitterionic PEG derivatives were obtained from a series of chemical reactions at room temperature. The results exhibited that as compared to the DLC-PEG, the hydrophilicity was much better with DLC-PEG-N-S and significantly increased atomic percentage of oxygen and nitrogen proved the entity of zwitterions on the surface of DLC-PEG-N-S. Meanwhile, the adsorption of blood proteins such as, human serum albumin (HSA) and fibrinogen was found considerably down-regulated in DLC-PEG-N-S, due mainly to the protein-repellant effect of PEG and zwitterion. Microscopic observation also revealed that as compared with the other substrates without zwitterion, the degree of platelet adhesion was the lowest with DLC-PEG-N-S. In addition, DLC-PEG-N-S retained an extended blood coagulation time as measured by activated partial thromboplastin time (APTT). The present results suggested that surface grafting of zwitterionic PEG derivatives could substantially enhance the blood compatibility of TiNi-DLC stent. In conclusion, anti-fouling properties of PEG and zwitterions are expected to be very useful in advancing overall stent performance.</description><subject>Adsorption</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Blood Coagulation</subject><subject>Carbon</subject><subject>Carbon - chemistry</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Coated Materials, Biocompatible - chemistry</subject><subject>Composites</subject><subject>Diamond - chemistry</subject><subject>Fibrinogen - chemistry</subject><subject>Glass</subject><subject>Humans</subject><subject>Ions</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Materials Science</subject><subject>Medical sciences</subject><subject>Natural Materials</subject><subject>Nickel - chemistry</subject><subject>Partial Thromboplastin Time</subject><subject>Platelet Adhesiveness</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polymer Sciences</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Stents</subject><subject>Surface chemistry</subject><subject>Surface Properties</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><subject>Titanium - chemistry</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0cuKFDEUBuAgitMz-gBuJAgyuogmVbnVUgZvMOBCXYdULm1mUkmbpJD26U3TrQOCuMoi3znJOT8ATwh-RTAWryvBknGECUF0GBli98CGMDEiKkd5H2zwxASibMRn4LzWG4wxnRh7CM4GMoiJi2EDbj-vxWvj4LZo30LawuzhHHO20ORlp1uYo4M_f4TWXAk5BQN3Oe5fuPZtH13qdXFvcnwJc4I26CUni2K4ddDoMueETNbNWVibS-0ReOB1rO7x6bwAX9-9_XL1AV1_ev_x6s01MnSSDXk7C2oFNoTPmhvmqBaYcey5FNa7gQosRu6dNMbNnA5EGM0sJ5awiQ3Mjhfg8th3V_L31dWmllCNi1Enl9eqJtyXhaWY_islJ0xyOZIun_0lb_JaUh_jgLCgE5EdkSMyJddanFe7EhZd9opgdUhMHRNTPTF1SEyxXvP01HidF2f_VPyOqIPnJ6Cr0dEXnUyod44SIft6uhuOrvartHXl7of_fv0XLjOuVQ</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>Lee, Bong Soo</creator><creator>Shin, Hong-Sub</creator><creator>Park, Kwideok</creator><creator>Han, Dong Keun</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0W</scope><scope>7X8</scope></search><sort><creationdate>20110301</creationdate><title>Surface grafting of blood compatible zwitterionic poly(ethylene glycol) on diamond-like carbon-coated stent</title><author>Lee, Bong Soo ; Shin, Hong-Sub ; Park, Kwideok ; Han, Dong Keun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-fdb74d70c16ba6c5e4a70560f687dfe2470736fe8cceb64217ca5d61d159525d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adsorption</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biological and medical sciences</topic><topic>Biomaterials</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Biomedical materials</topic><topic>Blood Coagulation</topic><topic>Carbon</topic><topic>Carbon - chemistry</topic><topic>Ceramics</topic><topic>Chemistry and Materials Science</topic><topic>Coated Materials, Biocompatible - chemistry</topic><topic>Composites</topic><topic>Diamond - chemistry</topic><topic>Fibrinogen - chemistry</topic><topic>Glass</topic><topic>Humans</topic><topic>Ions</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Materials Science</topic><topic>Medical sciences</topic><topic>Natural Materials</topic><topic>Nickel - chemistry</topic><topic>Partial Thromboplastin Time</topic><topic>Platelet Adhesiveness</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polymer Sciences</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Regenerative Medicine/Tissue Engineering</topic><topic>Stents</topic><topic>Surface chemistry</topic><topic>Surface Properties</topic><topic>Surfaces and Interfaces</topic><topic>Thin Films</topic><topic>Titanium - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Bong Soo</creatorcontrib><creatorcontrib>Shin, Hong-Sub</creatorcontrib><creatorcontrib>Park, Kwideok</creatorcontrib><creatorcontrib>Han, Dong Keun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>DELNET Engineering & Technology Collection</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials science. Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Bong Soo</au><au>Shin, Hong-Sub</au><au>Park, Kwideok</au><au>Han, Dong Keun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface grafting of blood compatible zwitterionic poly(ethylene glycol) on diamond-like carbon-coated stent</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>22</volume><issue>3</issue><spage>507</spage><epage>514</epage><pages>507-514</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Blood compatibility is the most important aspect for blood-contacting medical devices including cardiovascular stents. In this study, the surface of nickel–titanium (TiNi) stent was coated with diamond-like carbon (DLC) and then subsequently grafted by using zwitterion (N
+
and SO
3
−
)-linked poly(ethylene glycol) (PEG). We hypothesize that this coupling of zwitterion and PEG may significantly improve blood compatibility of DLC-coated TiNi stent. The surface modified TiNi stents, including PEG-grafted stent (DLC-PEG) and zwitterionic PEG-grafted one (DLC-PEG-N-S) were the main focus on the tests of surface characteristics and blood compatibility. The zwitterionic PEG derivatives were obtained from a series of chemical reactions at room temperature. The results exhibited that as compared to the DLC-PEG, the hydrophilicity was much better with DLC-PEG-N-S and significantly increased atomic percentage of oxygen and nitrogen proved the entity of zwitterions on the surface of DLC-PEG-N-S. Meanwhile, the adsorption of blood proteins such as, human serum albumin (HSA) and fibrinogen was found considerably down-regulated in DLC-PEG-N-S, due mainly to the protein-repellant effect of PEG and zwitterion. Microscopic observation also revealed that as compared with the other substrates without zwitterion, the degree of platelet adhesion was the lowest with DLC-PEG-N-S. In addition, DLC-PEG-N-S retained an extended blood coagulation time as measured by activated partial thromboplastin time (APTT). The present results suggested that surface grafting of zwitterionic PEG derivatives could substantially enhance the blood compatibility of TiNi-DLC stent. In conclusion, anti-fouling properties of PEG and zwitterions are expected to be very useful in advancing overall stent performance.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21279672</pmid><doi>10.1007/s10856-011-4235-5</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0957-4530 |
| ispartof | Journal of materials science. Materials in medicine, 2011-03, Vol.22 (3), p.507-514 |
| issn | 0957-4530 1573-4838 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902350879 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adsorption Biocompatible Materials - chemistry Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Blood Coagulation Carbon Carbon - chemistry Ceramics Chemistry and Materials Science Coated Materials, Biocompatible - chemistry Composites Diamond - chemistry Fibrinogen - chemistry Glass Humans Ions Magnetic Resonance Spectroscopy Materials Science Medical sciences Natural Materials Nickel - chemistry Partial Thromboplastin Time Platelet Adhesiveness Polyethylene Glycols - chemistry Polymer Sciences Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Regenerative Medicine/Tissue Engineering Stents Surface chemistry Surface Properties Surfaces and Interfaces Thin Films Titanium - chemistry |
| title | Surface grafting of blood compatible zwitterionic poly(ethylene glycol) on diamond-like carbon-coated stent |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T06%3A31%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Surface%20grafting%20of%20blood%20compatible%20zwitterionic%20poly(ethylene%20glycol)%20on%20diamond-like%20carbon-coated%20stent&rft.jtitle=Journal%20of%20materials%20science.%20Materials%20in%20medicine&rft.au=Lee,%20Bong%20Soo&rft.date=2011-03-01&rft.volume=22&rft.issue=3&rft.spage=507&rft.epage=514&rft.pages=507-514&rft.issn=0957-4530&rft.eissn=1573-4838&rft_id=info:doi/10.1007/s10856-011-4235-5&rft_dat=%3Cproquest_cross%3E902350879%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=861074918&rft_id=info:pmid/21279672&rfr_iscdi=true |