VP8 antigen produced in tobacco transplastomic plants confers protection against bovine rotavirus infection in a suckling mouse model

► In this work, we produce transplastomic tobacco plants expressing the BRV C486 VP8* protein. ► VP8* protein produced in tobacco chloroplasts accumulated as a very stable protein. ► VP8* plant extracts were able to induce a strong immune response in female mice. ► Female mice immunized with VP8* we...

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Veröffentlicht in:	Journal of biotechnology 2011-11, Vol.156 (2), p.100-107
Hauptverfasser:	Lentz, E.M., Mozgovoj, M.V., Bellido, D., Santos, M.J. Dus, Wigdorovitz, A., Bravo-Almonacid, F.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Animals, Suckling antigens Biological and medical sciences Biotechnology Bovine rotavirus calves Capsid Proteins - genetics Capsid Proteins - immunology Cattle Challenge chloroplasts coat proteins diarrhea enzyme-linked immunosorbent assay Female Fundamental and applied biological sciences. Psychology Group a rotavirus immune response leaves Mice neutralization neutralization tests Nicotiana Northern blotting plant extracts Protein Structure, Tertiary - genetics proteolysis recombinant proteins Recombinant Proteins - genetics Recombinant Proteins - immunology Rotavirus Rotavirus A Rotavirus Infections - immunology Rotavirus Infections - prevention & control Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - genetics Rotavirus Vaccines - immunology solubilization Southern blotting subunit vaccines suckling Tobacco Transplastomic plants Vaccination Vaccine Vaccines, Subunit - administration & dosage Vaccines, Subunit - genetics Vaccines, Subunit - immunology virion virulence viruses VP8 Western blotting
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