Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis
Background Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the r...
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| Veröffentlicht in: | Journal of clinical immunology 2011-02, Vol.31 (1), p.69-73 |
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| creator | Okubo, Masaaki Tahara, Tomomitsu Shibata, Tomoyuki Yamashita, Hiromi Nakamura, Masakatsu Yoshioka, Daisuke Yonemura, Joh Kamiya, Yoshio Ishizuka, Takamitsu Nakagawa, Yoshihito Nagasaka, Mitsuo Iwata, Masami Yamada, Hideto Hirata, Ichiro Arisawa, Tomiyasu |
| description | Background
Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.
Methods
The rs11614913 (T > C), rs2910164 (C > G), and rs3746444 (A > G) SNPs were genotyped in 170 UC and 403 control subjects.
Results
The rs3746444 AG genotype was significantly higher among the UC group (odds ratio (OR) = 1.51, 95% CI = 1.03–2.21,
p
= 0.037). The rs3746444 AG genotype was associated with onset at an older age (OR = 1.70, 95% CI = 1.04–2.78,
p
= 0.035), left-sided colitis and pancolitis (left-sided colitis, OR = 2.10, 95% CI = 1.12–3.94,
p
= 0.024; pancolitis, OR = 1.81, 95% CI = 1.09–3.01,
p
= 0.028, left-sided colitis + pancolitis, OR = 1.91, 95% CI = 1.26–2.92,
p
= 0.003), higher number of times hospitalized (OR = 2.63, 95% CI = 1.22–5.69,
p
= 0.017), steroid dependence (OR = 2.63, 95% CI = 1.27–5.44,
p
= 0.014), and refractory phenotypes (OR = 2.76, 95% CI = 1.46–5.21,
p
= 0.002) while the rs3746444 AA genotype was inversely associated with the number of times hospitalized (2∼, OR = 0.36, 95% CI = 0.17–0.79,
p
= 0.012), steroid dependence (OR = 0.42, 95% CI = 0.21–0.88,
p
= 0.021), and refractory phenotypes (OR = 0.38, 95% CI = 0.20–0.72,
p
= 0.003). The rs1161913 TT genotype also held a significantly higher risk of refractory phenotype (T/T vs. T/C + C/C, OR = 2.21, 95% CI = 1.17–4.18,
p
= 0.016).
Conclusions
Our results provided the first evidence that rs3746444 SNP may influence the susceptibility to UC, and both rs3746444 and rs11614913 SNPs may influence the pathophysiological features of UC. |
| doi_str_mv | 10.1007/s10875-010-9461-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902349472</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902349472</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-9442b85e56b11ca7f0da2692757e607ec4685a42b2cb97aaac660db7e4fbbf073</originalsourceid><addsrcrecordid>eNqFkUtLJTEQhYM46PXxA9xI48ZVO5V0Hp3l5eILZGaYUbchnVs9RvqhSbdy_725tjowIK5Cqr5ziqpDyAGFEwqgvkcKpRI5UMg1lzRfbZAZFarImdBsk8yAKZprytk22YnxHgAKycQW2WZQ8pJKNSN2HmPvvB1832V_hnG5yvo6W_Rtm_7n2OHgXXZrg7fdEDPfZb8C5q13of_9Yz4VkhbXzWc_3GU3jcOQKk-YTBo_-LhHvtW2ibj_9u6Sm7PT68VFfvXz_HIxv8odL_iQFuCsKgUKWVHqrKphaZnUTAmFEhQ6LkthE8NcpZW11kkJy0ohr6uqBlXskuPJ9yH0jyPGwbQ-Omwa22E_RqOBFVxzxb4kS8Vpug6jX5NCgyi1hkQe_Ufe92Po0sIJKhUo-jqYTlA6X4wBa_MQfGvDylAw60TNlKhJiZp1omaVNIdvxmPV4vJD8R5hAtgExNTq_mL4N_lz1xfSBKtP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>858707172</pqid></control><display><type>article</type><title>Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Okubo, Masaaki ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Yamashita, Hiromi ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Yonemura, Joh ; Kamiya, Yoshio ; Ishizuka, Takamitsu ; Nakagawa, Yoshihito ; Nagasaka, Mitsuo ; Iwata, Masami ; Yamada, Hideto ; Hirata, Ichiro ; Arisawa, Tomiyasu</creator><creatorcontrib>Okubo, Masaaki ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Yamashita, Hiromi ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Yonemura, Joh ; Kamiya, Yoshio ; Ishizuka, Takamitsu ; Nakagawa, Yoshihito ; Nagasaka, Mitsuo ; Iwata, Masami ; Yamada, Hideto ; Hirata, Ichiro ; Arisawa, Tomiyasu</creatorcontrib><description>Background
Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.
Methods
The rs11614913 (T > C), rs2910164 (C > G), and rs3746444 (A > G) SNPs were genotyped in 170 UC and 403 control subjects.
Results
The rs3746444 AG genotype was significantly higher among the UC group (odds ratio (OR) = 1.51, 95% CI = 1.03–2.21,
p
= 0.037). The rs3746444 AG genotype was associated with onset at an older age (OR = 1.70, 95% CI = 1.04–2.78,
p
= 0.035), left-sided colitis and pancolitis (left-sided colitis, OR = 2.10, 95% CI = 1.12–3.94,
p
= 0.024; pancolitis, OR = 1.81, 95% CI = 1.09–3.01,
p
= 0.028, left-sided colitis + pancolitis, OR = 1.91, 95% CI = 1.26–2.92,
p
= 0.003), higher number of times hospitalized (OR = 2.63, 95% CI = 1.22–5.69,
p
= 0.017), steroid dependence (OR = 2.63, 95% CI = 1.27–5.44,
p
= 0.014), and refractory phenotypes (OR = 2.76, 95% CI = 1.46–5.21,
p
= 0.002) while the rs3746444 AA genotype was inversely associated with the number of times hospitalized (2∼, OR = 0.36, 95% CI = 0.17–0.79,
p
= 0.012), steroid dependence (OR = 0.42, 95% CI = 0.21–0.88,
p
= 0.021), and refractory phenotypes (OR = 0.38, 95% CI = 0.20–0.72,
p
= 0.003). The rs1161913 TT genotype also held a significantly higher risk of refractory phenotype (T/T vs. T/C + C/C, OR = 2.21, 95% CI = 1.17–4.18,
p
= 0.016).
Conclusions
Our results provided the first evidence that rs3746444 SNP may influence the susceptibility to UC, and both rs3746444 and rs11614913 SNPs may influence the pathophysiological features of UC.</description><identifier>ISSN: 0271-9142</identifier><identifier>EISSN: 1573-2592</identifier><identifier>DOI: 10.1007/s10875-010-9461-y</identifier><identifier>PMID: 20848167</identifier><identifier>CODEN: JCIMDO</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Asian Continental Ancestry Group - genetics ; Biomedical and Life Sciences ; Biomedicine ; Colitis, Ulcerative - genetics ; Colitis, Ulcerative - physiopathology ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Geriatrics ; Humans ; Immunology ; Infectious Diseases ; Internal Medicine ; Male ; Medical Microbiology ; MicroRNAs - genetics ; Middle Aged ; miRNA ; Polymorphism, Single Nucleotide - genetics ; Risk factors ; Single-nucleotide polymorphism ; Steroid hormones ; Ulcerative colitis</subject><ispartof>Journal of clinical immunology, 2011-02, Vol.31 (1), p.69-73</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-9442b85e56b11ca7f0da2692757e607ec4685a42b2cb97aaac660db7e4fbbf073</citedby><cites>FETCH-LOGICAL-c434t-9442b85e56b11ca7f0da2692757e607ec4685a42b2cb97aaac660db7e4fbbf073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10875-010-9461-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10875-010-9461-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20848167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okubo, Masaaki</creatorcontrib><creatorcontrib>Tahara, Tomomitsu</creatorcontrib><creatorcontrib>Shibata, Tomoyuki</creatorcontrib><creatorcontrib>Yamashita, Hiromi</creatorcontrib><creatorcontrib>Nakamura, Masakatsu</creatorcontrib><creatorcontrib>Yoshioka, Daisuke</creatorcontrib><creatorcontrib>Yonemura, Joh</creatorcontrib><creatorcontrib>Kamiya, Yoshio</creatorcontrib><creatorcontrib>Ishizuka, Takamitsu</creatorcontrib><creatorcontrib>Nakagawa, Yoshihito</creatorcontrib><creatorcontrib>Nagasaka, Mitsuo</creatorcontrib><creatorcontrib>Iwata, Masami</creatorcontrib><creatorcontrib>Yamada, Hideto</creatorcontrib><creatorcontrib>Hirata, Ichiro</creatorcontrib><creatorcontrib>Arisawa, Tomiyasu</creatorcontrib><title>Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis</title><title>Journal of clinical immunology</title><addtitle>J Clin Immunol</addtitle><addtitle>J Clin Immunol</addtitle><description>Background
Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.
Methods
The rs11614913 (T > C), rs2910164 (C > G), and rs3746444 (A > G) SNPs were genotyped in 170 UC and 403 control subjects.
Results
The rs3746444 AG genotype was significantly higher among the UC group (odds ratio (OR) = 1.51, 95% CI = 1.03–2.21,
p
= 0.037). The rs3746444 AG genotype was associated with onset at an older age (OR = 1.70, 95% CI = 1.04–2.78,
p
= 0.035), left-sided colitis and pancolitis (left-sided colitis, OR = 2.10, 95% CI = 1.12–3.94,
p
= 0.024; pancolitis, OR = 1.81, 95% CI = 1.09–3.01,
p
= 0.028, left-sided colitis + pancolitis, OR = 1.91, 95% CI = 1.26–2.92,
p
= 0.003), higher number of times hospitalized (OR = 2.63, 95% CI = 1.22–5.69,
p
= 0.017), steroid dependence (OR = 2.63, 95% CI = 1.27–5.44,
p
= 0.014), and refractory phenotypes (OR = 2.76, 95% CI = 1.46–5.21,
p
= 0.002) while the rs3746444 AA genotype was inversely associated with the number of times hospitalized (2∼, OR = 0.36, 95% CI = 0.17–0.79,
p
= 0.012), steroid dependence (OR = 0.42, 95% CI = 0.21–0.88,
p
= 0.021), and refractory phenotypes (OR = 0.38, 95% CI = 0.20–0.72,
p
= 0.003). The rs1161913 TT genotype also held a significantly higher risk of refractory phenotype (T/T vs. T/C + C/C, OR = 2.21, 95% CI = 1.17–4.18,
p
= 0.016).
Conclusions
Our results provided the first evidence that rs3746444 SNP may influence the susceptibility to UC, and both rs3746444 and rs11614913 SNPs may influence the pathophysiological features of UC.</description><subject>Adult</subject><subject>Aged</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Colitis, Ulcerative - genetics</subject><subject>Colitis, Ulcerative - physiopathology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>miRNA</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Risk factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Steroid hormones</subject><subject>Ulcerative colitis</subject><issn>0271-9142</issn><issn>1573-2592</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtLJTEQhYM46PXxA9xI48ZVO5V0Hp3l5eILZGaYUbchnVs9RvqhSbdy_725tjowIK5Cqr5ziqpDyAGFEwqgvkcKpRI5UMg1lzRfbZAZFarImdBsk8yAKZprytk22YnxHgAKycQW2WZQ8pJKNSN2HmPvvB1832V_hnG5yvo6W_Rtm_7n2OHgXXZrg7fdEDPfZb8C5q13of_9Yz4VkhbXzWc_3GU3jcOQKk-YTBo_-LhHvtW2ibj_9u6Sm7PT68VFfvXz_HIxv8odL_iQFuCsKgUKWVHqrKphaZnUTAmFEhQ6LkthE8NcpZW11kkJy0ohr6uqBlXskuPJ9yH0jyPGwbQ-Omwa22E_RqOBFVxzxb4kS8Vpug6jX5NCgyi1hkQe_Ufe92Po0sIJKhUo-jqYTlA6X4wBa_MQfGvDylAw60TNlKhJiZp1omaVNIdvxmPV4vJD8R5hAtgExNTq_mL4N_lz1xfSBKtP</recordid><startdate>201102</startdate><enddate>201102</enddate><creator>Okubo, Masaaki</creator><creator>Tahara, Tomomitsu</creator><creator>Shibata, Tomoyuki</creator><creator>Yamashita, Hiromi</creator><creator>Nakamura, Masakatsu</creator><creator>Yoshioka, Daisuke</creator><creator>Yonemura, Joh</creator><creator>Kamiya, Yoshio</creator><creator>Ishizuka, Takamitsu</creator><creator>Nakagawa, Yoshihito</creator><creator>Nagasaka, Mitsuo</creator><creator>Iwata, Masami</creator><creator>Yamada, Hideto</creator><creator>Hirata, Ichiro</creator><creator>Arisawa, Tomiyasu</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>201102</creationdate><title>Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis</title><author>Okubo, Masaaki ; Tahara, Tomomitsu ; Shibata, Tomoyuki ; Yamashita, Hiromi ; Nakamura, Masakatsu ; Yoshioka, Daisuke ; Yonemura, Joh ; Kamiya, Yoshio ; Ishizuka, Takamitsu ; Nakagawa, Yoshihito ; Nagasaka, Mitsuo ; Iwata, Masami ; Yamada, Hideto ; Hirata, Ichiro ; Arisawa, Tomiyasu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-9442b85e56b11ca7f0da2692757e607ec4685a42b2cb97aaac660db7e4fbbf073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Colitis, Ulcerative - genetics</topic><topic>Colitis, Ulcerative - physiopathology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>miRNA</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Risk factors</topic><topic>Single-nucleotide polymorphism</topic><topic>Steroid hormones</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okubo, Masaaki</creatorcontrib><creatorcontrib>Tahara, Tomomitsu</creatorcontrib><creatorcontrib>Shibata, Tomoyuki</creatorcontrib><creatorcontrib>Yamashita, Hiromi</creatorcontrib><creatorcontrib>Nakamura, Masakatsu</creatorcontrib><creatorcontrib>Yoshioka, Daisuke</creatorcontrib><creatorcontrib>Yonemura, Joh</creatorcontrib><creatorcontrib>Kamiya, Yoshio</creatorcontrib><creatorcontrib>Ishizuka, Takamitsu</creatorcontrib><creatorcontrib>Nakagawa, Yoshihito</creatorcontrib><creatorcontrib>Nagasaka, Mitsuo</creatorcontrib><creatorcontrib>Iwata, Masami</creatorcontrib><creatorcontrib>Yamada, Hideto</creatorcontrib><creatorcontrib>Hirata, Ichiro</creatorcontrib><creatorcontrib>Arisawa, Tomiyasu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Journal of clinical immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okubo, Masaaki</au><au>Tahara, Tomomitsu</au><au>Shibata, Tomoyuki</au><au>Yamashita, Hiromi</au><au>Nakamura, Masakatsu</au><au>Yoshioka, Daisuke</au><au>Yonemura, Joh</au><au>Kamiya, Yoshio</au><au>Ishizuka, Takamitsu</au><au>Nakagawa, Yoshihito</au><au>Nagasaka, Mitsuo</au><au>Iwata, Masami</au><au>Yamada, Hideto</au><au>Hirata, Ichiro</au><au>Arisawa, Tomiyasu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis</atitle><jtitle>Journal of clinical immunology</jtitle><stitle>J Clin Immunol</stitle><addtitle>J Clin Immunol</addtitle><date>2011-02</date><risdate>2011</risdate><volume>31</volume><issue>1</issue><spage>69</spage><epage>73</epage><pages>69-73</pages><issn>0271-9142</issn><eissn>1573-2592</eissn><coden>JCIMDO</coden><abstract>Background
Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human diseases. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of ulcerative colitis (UC) in a Japanese population.
Methods
The rs11614913 (T > C), rs2910164 (C > G), and rs3746444 (A > G) SNPs were genotyped in 170 UC and 403 control subjects.
Results
The rs3746444 AG genotype was significantly higher among the UC group (odds ratio (OR) = 1.51, 95% CI = 1.03–2.21,
p
= 0.037). The rs3746444 AG genotype was associated with onset at an older age (OR = 1.70, 95% CI = 1.04–2.78,
p
= 0.035), left-sided colitis and pancolitis (left-sided colitis, OR = 2.10, 95% CI = 1.12–3.94,
p
= 0.024; pancolitis, OR = 1.81, 95% CI = 1.09–3.01,
p
= 0.028, left-sided colitis + pancolitis, OR = 1.91, 95% CI = 1.26–2.92,
p
= 0.003), higher number of times hospitalized (OR = 2.63, 95% CI = 1.22–5.69,
p
= 0.017), steroid dependence (OR = 2.63, 95% CI = 1.27–5.44,
p
= 0.014), and refractory phenotypes (OR = 2.76, 95% CI = 1.46–5.21,
p
= 0.002) while the rs3746444 AA genotype was inversely associated with the number of times hospitalized (2∼, OR = 0.36, 95% CI = 0.17–0.79,
p
= 0.012), steroid dependence (OR = 0.42, 95% CI = 0.21–0.88,
p
= 0.021), and refractory phenotypes (OR = 0.38, 95% CI = 0.20–0.72,
p
= 0.003). The rs1161913 TT genotype also held a significantly higher risk of refractory phenotype (T/T vs. T/C + C/C, OR = 2.21, 95% CI = 1.17–4.18,
p
= 0.016).
Conclusions
Our results provided the first evidence that rs3746444 SNP may influence the susceptibility to UC, and both rs3746444 and rs11614913 SNPs may influence the pathophysiological features of UC.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>20848167</pmid><doi>10.1007/s10875-010-9461-y</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0271-9142 |
| ispartof | Journal of clinical immunology, 2011-02, Vol.31 (1), p.69-73 |
| issn | 0271-9142 1573-2592 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902349472 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Asian Continental Ancestry Group - genetics Biomedical and Life Sciences Biomedicine Colitis, Ulcerative - genetics Colitis, Ulcerative - physiopathology Female Genetic Predisposition to Disease - genetics Genotype Geriatrics Humans Immunology Infectious Diseases Internal Medicine Male Medical Microbiology MicroRNAs - genetics Middle Aged miRNA Polymorphism, Single Nucleotide - genetics Risk factors Single-nucleotide polymorphism Steroid hormones Ulcerative colitis |
| title | Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T09%3A05%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20Study%20of%20Common%20Genetic%20Variants%20in%20Pre-microRNAs%20in%20Patients%20with%20Ulcerative%20Colitis&rft.jtitle=Journal%20of%20clinical%20immunology&rft.au=Okubo,%20Masaaki&rft.date=2011-02&rft.volume=31&rft.issue=1&rft.spage=69&rft.epage=73&rft.pages=69-73&rft.issn=0271-9142&rft.eissn=1573-2592&rft.coden=JCIMDO&rft_id=info:doi/10.1007/s10875-010-9461-y&rft_dat=%3Cproquest_cross%3E902349472%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=858707172&rft_id=info:pmid/20848167&rfr_iscdi=true |