effect of combination treatment with docosahexaenoic acid and 5-fluorouracil on the mRNA expression of apoptosis-related genes, including the novel gene BCL2L12, in gastric cancer cells

Docosahexaenoic acid (DHA) plays an important role in suppressing the growth of cancer. In this paper, the synergetic anticancer effect of combination DHA with 5-fluorouracil (5-FU) was investigated in gastric carcinoma cells. We found that DHA inhibited the growth of cultured SGC7901 cells at diffe...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2009, Vol.45 (1-2), p.69-74
Hauptverfasser:	Zhuo, Zhihong, Zhang, Leming, Mu, Qitian, Lou, Yanru, Gong, Zhaohui, Shi, Yijiu, Ouyang, Guifang, Zhang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animal Genetics and Genomics Antimetabolites, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Antineoplastics Apoptosis Apoptosis - drug effects Bax protein Bcl-2 protein Biomedical and Life Sciences Breast cancer Carcinoma Caspase-9 CD95 antigen Cell Biology Cell Culture Cell growth Cell Growth/Differentiation/Apoptosis Cell Line, Tumor Cell lines Colorectal cancer Developmental Biology Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Dosage Dose-Response Relationship, Drug Drug Synergism Fas antigen Fatty acids Fluorouracil - pharmacology Gastric cancer Gene expression Gene Expression Regulation, Developmental - drug effects Humans Life Sciences Messenger RNA Muscle Proteins - genetics Muscle Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - metabolism Stem Cells Stomach Neoplasms - pathology Stomach Neoplasms - physiopathology
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