Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque
Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by m...
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| Veröffentlicht in: | Immunogenetics (New York) 2011-05, Vol.63 (5), p.267-274 |
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| creator | Aarnink, Alice Dereuddre-Bosquet, Nathalie Vaslin, Bruno Le Grand, Roger Winterton, Peter Apoil, Pol-André Blancher, Antoine |
| description | Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites revealed seven haplotypes (H1–H7). We present statistical evidence of the influence of MHC polymorphism on the set-point plasma viral load (PVL). Our analysis was based on the study of 45 Mauritian cynomolgus macaques inoculated by intravenous or intrarectal injection of a 50 AID50 dose of the SIVmac251 virus. The animals received no treatment before or after the inoculation. MHC polymorphism was investigated by means of 20 microsatellites distributed across the MHC and by
DRB
genotyping using the DGGE sequencing method. Statistical analysis with
Unphased
software revealed that two markers located in the class IB region significantly influenced the Log PVL and that three class IB haplotypes were significantly associated with lower (H2 or H6) or higher (H4) set-point Log PVL values. Although the impact of MHC on Log PVL was found to be low (around one Log10), it is important to dispose of animals paired for their MHC genotypes, each animal tested for a given treatment and its untreated control, to minimize the influence of the MHC and clearly reveal the effect of the treatment. |
| doi_str_mv | 10.1007/s00251-010-0504-6 |
| format | Article |
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DRB
genotyping using the DGGE sequencing method. Statistical analysis with
Unphased
software revealed that two markers located in the class IB region significantly influenced the Log PVL and that three class IB haplotypes were significantly associated with lower (H2 or H6) or higher (H4) set-point Log PVL values. Although the impact of MHC on Log PVL was found to be low (around one Log10), it is important to dispose of animals paired for their MHC genotypes, each animal tested for a given treatment and its untreated control, to minimize the influence of the MHC and clearly reveal the effect of the treatment.</description><identifier>ISSN: 0093-7711</identifier><identifier>EISSN: 1432-1211</identifier><identifier>DOI: 10.1007/s00251-010-0504-6</identifier><identifier>PMID: 21234560</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Allergology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cynomolgus ; Disease Models, Animal ; Disease Progression ; Gene Function ; Genetic Markers ; Genotype & phenotype ; Genotypes ; Haplotypes ; Haplotypes - genetics ; HIV ; HIV Infections - genetics ; HIV Infections - immunology ; Human Genetics ; Human immunodeficiency virus ; Immune system ; Immunology ; Infections ; Internet resources ; Macaca ; Macaca fascicularis ; Major Histocompatibility Complex - genetics ; Major Histocompatibility Complex - immunology ; Male ; Microsatellite Repeats ; Mitochondrial DNA ; Original Paper ; Plasma ; Polymorphism ; Polymorphism, Genetic ; Satellites ; Sequence Analysis, DNA - methods ; Simian Acquired Immunodeficiency Syndrome - blood ; Simian Acquired Immunodeficiency Syndrome - genetics ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian immunodeficiency virus ; Statistical analysis ; Viral Load ; Viruses</subject><ispartof>Immunogenetics (New York), 2011-05, Vol.63 (5), p.267-274</ispartof><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-a4f9b42bd6a47125d40a3b582be0b2221196cc3c7dda4485ab31248b506cf4e13</citedby><cites>FETCH-LOGICAL-c468t-a4f9b42bd6a47125d40a3b582be0b2221196cc3c7dda4485ab31248b506cf4e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00251-010-0504-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00251-010-0504-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21234560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aarnink, Alice</creatorcontrib><creatorcontrib>Dereuddre-Bosquet, Nathalie</creatorcontrib><creatorcontrib>Vaslin, Bruno</creatorcontrib><creatorcontrib>Le Grand, Roger</creatorcontrib><creatorcontrib>Winterton, Peter</creatorcontrib><creatorcontrib>Apoil, Pol-André</creatorcontrib><creatorcontrib>Blancher, Antoine</creatorcontrib><title>Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque</title><title>Immunogenetics (New York)</title><addtitle>Immunogenetics</addtitle><addtitle>Immunogenetics</addtitle><description>Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites revealed seven haplotypes (H1–H7). We present statistical evidence of the influence of MHC polymorphism on the set-point plasma viral load (PVL). Our analysis was based on the study of 45 Mauritian cynomolgus macaques inoculated by intravenous or intrarectal injection of a 50 AID50 dose of the SIVmac251 virus. The animals received no treatment before or after the inoculation. MHC polymorphism was investigated by means of 20 microsatellites distributed across the MHC and by
DRB
genotyping using the DGGE sequencing method. Statistical analysis with
Unphased
software revealed that two markers located in the class IB region significantly influenced the Log PVL and that three class IB haplotypes were significantly associated with lower (H2 or H6) or higher (H4) set-point Log PVL values. Although the impact of MHC on Log PVL was found to be low (around one Log10), it is important to dispose of animals paired for their MHC genotypes, each animal tested for a given treatment and its untreated control, to minimize the influence of the MHC and clearly reveal the effect of the treatment.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Allergology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Cynomolgus</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Gene Function</subject><subject>Genetic Markers</subject><subject>Genotype & phenotype</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>HIV</subject><subject>HIV Infections - genetics</subject><subject>HIV Infections - immunology</subject><subject>Human Genetics</subject><subject>Human immunodeficiency virus</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Infections</subject><subject>Internet resources</subject><subject>Macaca</subject><subject>Macaca fascicularis</subject><subject>Major Histocompatibility Complex - genetics</subject><subject>Major Histocompatibility Complex - immunology</subject><subject>Male</subject><subject>Microsatellite Repeats</subject><subject>Mitochondrial DNA</subject><subject>Original Paper</subject><subject>Plasma</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Satellites</subject><subject>Sequence Analysis, DNA - methods</subject><subject>Simian Acquired Immunodeficiency Syndrome - blood</subject><subject>Simian Acquired Immunodeficiency Syndrome - genetics</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian immunodeficiency virus</subject><subject>Statistical analysis</subject><subject>Viral Load</subject><subject>Viruses</subject><issn>0093-7711</issn><issn>1432-1211</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1v1DAQhq0KRJfCD-gFRVx6Csz4K8mxWrV0pVYc-LhajjPZpkqcrZ1I7L_HIaVISIiT5Znnna-XsXOEDwhQfIwAXGEOCDkokLk-YRuUgufIEV-wDUAl8qJAPGWvY3wAQFVx_YqdcuRCKg0bFna-7WfyjrKxzaZ7yu5uttme_DgdDynmf8UOYdwHirFL_4TRjwOFbiA_2T77svuedb4lNy3ZbhXc2Tl0U2d95o5-HMZ-P8dssM4-zvSGvWxtH-nt03vGvl1ffd3e5LefP-22l7e5k7qccivbqpa8brSVBXLVSLCiViWvCWrO04aVdk64ommslKWytUAuy1qBdq0kFGfsYq2bpk9t42SGLjrqe-tpnKOpIB2h4uL_ZKmqQoqqWMj3f5EP4xx8WmOBBJdaFQnCFXJhjDFQaw7pWjYcDYJZjDOrcSYZZxbjjE6ad0-F53qg5lnx26kE8BWIKeX3FP50_nfVn59Fork</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Aarnink, Alice</creator><creator>Dereuddre-Bosquet, Nathalie</creator><creator>Vaslin, Bruno</creator><creator>Le Grand, Roger</creator><creator>Winterton, Peter</creator><creator>Apoil, Pol-André</creator><creator>Blancher, Antoine</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110501</creationdate><title>Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque</title><author>Aarnink, Alice ; Dereuddre-Bosquet, Nathalie ; Vaslin, Bruno ; Le Grand, Roger ; Winterton, Peter ; Apoil, Pol-André ; Blancher, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-a4f9b42bd6a47125d40a3b582be0b2221196cc3c7dda4485ab31248b506cf4e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Allergology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Cynomolgus</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Gene Function</topic><topic>Genetic Markers</topic><topic>Genotype & phenotype</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>HIV</topic><topic>HIV Infections - genetics</topic><topic>HIV Infections - immunology</topic><topic>Human Genetics</topic><topic>Human immunodeficiency virus</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Infections</topic><topic>Internet resources</topic><topic>Macaca</topic><topic>Macaca fascicularis</topic><topic>Major Histocompatibility Complex - genetics</topic><topic>Major Histocompatibility Complex - immunology</topic><topic>Male</topic><topic>Microsatellite Repeats</topic><topic>Mitochondrial DNA</topic><topic>Original Paper</topic><topic>Plasma</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Satellites</topic><topic>Sequence Analysis, DNA - methods</topic><topic>Simian Acquired Immunodeficiency Syndrome - blood</topic><topic>Simian Acquired Immunodeficiency Syndrome - genetics</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian immunodeficiency virus</topic><topic>Statistical analysis</topic><topic>Viral Load</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aarnink, Alice</creatorcontrib><creatorcontrib>Dereuddre-Bosquet, Nathalie</creatorcontrib><creatorcontrib>Vaslin, Bruno</creatorcontrib><creatorcontrib>Le Grand, Roger</creatorcontrib><creatorcontrib>Winterton, Peter</creatorcontrib><creatorcontrib>Apoil, Pol-André</creatorcontrib><creatorcontrib>Blancher, Antoine</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunogenetics (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aarnink, Alice</au><au>Dereuddre-Bosquet, Nathalie</au><au>Vaslin, Bruno</au><au>Le Grand, Roger</au><au>Winterton, Peter</au><au>Apoil, Pol-André</au><au>Blancher, Antoine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque</atitle><jtitle>Immunogenetics (New York)</jtitle><stitle>Immunogenetics</stitle><addtitle>Immunogenetics</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>63</volume><issue>5</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><abstract>Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites revealed seven haplotypes (H1–H7). We present statistical evidence of the influence of MHC polymorphism on the set-point plasma viral load (PVL). Our analysis was based on the study of 45 Mauritian cynomolgus macaques inoculated by intravenous or intrarectal injection of a 50 AID50 dose of the SIVmac251 virus. The animals received no treatment before or after the inoculation. MHC polymorphism was investigated by means of 20 microsatellites distributed across the MHC and by
DRB
genotyping using the DGGE sequencing method. Statistical analysis with
Unphased
software revealed that two markers located in the class IB region significantly influenced the Log PVL and that three class IB haplotypes were significantly associated with lower (H2 or H6) or higher (H4) set-point Log PVL values. Although the impact of MHC on Log PVL was found to be low (around one Log10), it is important to dispose of animals paired for their MHC genotypes, each animal tested for a given treatment and its untreated control, to minimize the influence of the MHC and clearly reveal the effect of the treatment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21234560</pmid><doi>10.1007/s00251-010-0504-6</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acquired immune deficiency syndrome AIDS Allergology Animals Biomedical and Life Sciences Biomedicine Cell Biology Cynomolgus Disease Models, Animal Disease Progression Gene Function Genetic Markers Genotype & phenotype Genotypes Haplotypes Haplotypes - genetics HIV HIV Infections - genetics HIV Infections - immunology Human Genetics Human immunodeficiency virus Immune system Immunology Infections Internet resources Macaca Macaca fascicularis Major Histocompatibility Complex - genetics Major Histocompatibility Complex - immunology Male Microsatellite Repeats Mitochondrial DNA Original Paper Plasma Polymorphism Polymorphism, Genetic Satellites Sequence Analysis, DNA - methods Simian Acquired Immunodeficiency Syndrome - blood Simian Acquired Immunodeficiency Syndrome - genetics Simian Acquired Immunodeficiency Syndrome - immunology Simian immunodeficiency virus Statistical analysis Viral Load Viruses |
| title | Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque |
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