Oxidative stress in the blood of farm workers following intensive pesticide exposure
The aim of this study was to evaluate oxidative stress in workers who formulate organophosphate, synthetic pyrethroid and carbamate pesticides. In this survey, blood erythrocytes from a group of 94 pesticide-formulating workers (at least 5-years experience in pest-control in apple and cherry product...
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| Veröffentlicht in: | Toxicology and industrial health 2011-10, Vol.27 (9), p.820-825 |
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| creator | Ogut, Serdal Gultekin, Fatih Nesimi Kisioglu, A. Kucukoner, Erdoğan |
| description | The aim of this study was to evaluate oxidative stress in workers who formulate organophosphate, synthetic pyrethroid and carbamate pesticides. In this survey, blood erythrocytes from a group of 94 pesticide-formulating workers (at least 5-years experience in pest-control in apple and cherry production) and 45 control subjects were examined for oxidative stress parameters. The control group was composed of 45 healthy people living in the same region with no exposure to pesticides. Lipid peroxidation level, catalase, superoxide dismutase and glutathione peroxidase activities in erythrocytes were analysed as biomarkers of oxidative stress. In addition, the acetylcholinesterase activity was measured as a biomarker of toxicity. Results indicated that chronic exposure to organophosphate, synthetic pyrethroid and carbamate pesticides were associated with increased activities of catalase, SOD and lipid peroxidation in erythrocytes (p < 0.05). Acetylcholinesterase activity did not show any significant differences between the two groups (p > 0.05). It is concluded that human chronic exposure to pesticides may result in stimulated antioxidant enzymes. |
| doi_str_mv | 10.1177/0748233711399311 |
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In this survey, blood erythrocytes from a group of 94 pesticide-formulating workers (at least 5-years experience in pest-control in apple and cherry production) and 45 control subjects were examined for oxidative stress parameters. The control group was composed of 45 healthy people living in the same region with no exposure to pesticides. Lipid peroxidation level, catalase, superoxide dismutase and glutathione peroxidase activities in erythrocytes were analysed as biomarkers of oxidative stress. In addition, the acetylcholinesterase activity was measured as a biomarker of toxicity. Results indicated that chronic exposure to organophosphate, synthetic pyrethroid and carbamate pesticides were associated with increased activities of catalase, SOD and lipid peroxidation in erythrocytes (p < 0.05). Acetylcholinesterase activity did not show any significant differences between the two groups (p > 0.05). It is concluded that human chronic exposure to pesticides may result in stimulated antioxidant enzymes.</description><identifier>ISSN: 0748-2337</identifier><identifier>EISSN: 1477-0393</identifier><identifier>DOI: 10.1177/0748233711399311</identifier><identifier>PMID: 21450927</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acids ; Adult ; Agriculture - manpower ; Biomarkers ; Biomarkers - blood ; Carbamates - toxicity ; Cholinesterase Inhibitors - toxicity ; Chronic illnesses ; Enzymes ; Erythrocytes - enzymology ; Erythrocytes - metabolism ; Farmworkers ; Female ; Free radicals ; Fruit ; Human subjects ; Humans ; Insecticides - toxicity ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Male ; Malus ; Medicine ; Occupational Exposure ; Organophosphates - toxicity ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidoreductases - blood ; Pesticides ; Pesticides - toxicity ; Prunus ; Pyrethrins - toxicity ; Questionnaires ; Time Factors ; Toxicity ; Toxicology ; Turkey ; Workers</subject><ispartof>Toxicology and industrial health, 2011-10, Vol.27 (9), p.820-825</ispartof><rights>The Author(s) 2011</rights><rights>SAGE Publications © Oct 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-d786fab2de130d6ee00b3a7aa7b42cbe05d6279371f722c109d2ce458e74b4f3</citedby><cites>FETCH-LOGICAL-c395t-d786fab2de130d6ee00b3a7aa7b42cbe05d6279371f722c109d2ce458e74b4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0748233711399311$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0748233711399311$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21450927$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogut, Serdal</creatorcontrib><creatorcontrib>Gultekin, Fatih</creatorcontrib><creatorcontrib>Nesimi Kisioglu, A.</creatorcontrib><creatorcontrib>Kucukoner, Erdoğan</creatorcontrib><title>Oxidative stress in the blood of farm workers following intensive pesticide exposure</title><title>Toxicology and industrial health</title><addtitle>Toxicol Ind Health</addtitle><description>The aim of this study was to evaluate oxidative stress in workers who formulate organophosphate, synthetic pyrethroid and carbamate pesticides. In this survey, blood erythrocytes from a group of 94 pesticide-formulating workers (at least 5-years experience in pest-control in apple and cherry production) and 45 control subjects were examined for oxidative stress parameters. The control group was composed of 45 healthy people living in the same region with no exposure to pesticides. Lipid peroxidation level, catalase, superoxide dismutase and glutathione peroxidase activities in erythrocytes were analysed as biomarkers of oxidative stress. In addition, the acetylcholinesterase activity was measured as a biomarker of toxicity. Results indicated that chronic exposure to organophosphate, synthetic pyrethroid and carbamate pesticides were associated with increased activities of catalase, SOD and lipid peroxidation in erythrocytes (p < 0.05). Acetylcholinesterase activity did not show any significant differences between the two groups (p > 0.05). It is concluded that human chronic exposure to pesticides may result in stimulated antioxidant enzymes.</description><subject>Acids</subject><subject>Adult</subject><subject>Agriculture - manpower</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Carbamates - toxicity</subject><subject>Cholinesterase Inhibitors - toxicity</subject><subject>Chronic illnesses</subject><subject>Enzymes</subject><subject>Erythrocytes - enzymology</subject><subject>Erythrocytes - metabolism</subject><subject>Farmworkers</subject><subject>Female</subject><subject>Free radicals</subject><subject>Fruit</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Insecticides - toxicity</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Male</subject><subject>Malus</subject><subject>Medicine</subject><subject>Occupational Exposure</subject><subject>Organophosphates - 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Factors</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Turkey</subject><subject>Workers</subject><issn>0748-2337</issn><issn>1477-0393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkb1PwzAQxS0EouVjZ0IWC1PgbCdxPKKKL6lSl-6RE19KShIXO6HlvyehBaRKiOmG-7139_QIuWBww5iUtyDDhAshGRNKCcYOyJiFUgYglDgk42EdDPsROfF-CQBxHPFjMuIsjEBxOSbz2aY0ui3fkfrWofe0bGj7gjSrrDXUFrTQrqZr617ReVrYqrLrsln0WIuNH3Qr9G2ZlwYpblbWdw7PyFGhK4_nu3lK5g_388lTMJ09Pk_upkEuVNQGRiZxoTNukAkwMSJAJrTUWmYhzzOEyMRcqj5eITnPGSjDcwyjBGWYhYU4Jddb25Wzb13_RVqXPseq0g3azqcKuAgVsPhfMlFJBIwz0ZNXe-TSdq7pU3xBSSLlYAdbKHfWe4dFunJlrd1HyiAdikn3i-kllzvfLqvR_Ai-m-iBYAt4vcDfo38afgJf9ZU-</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Ogut, 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Erdoğan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidative stress in the blood of farm workers following intensive pesticide exposure</atitle><jtitle>Toxicology and industrial health</jtitle><addtitle>Toxicol Ind Health</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>27</volume><issue>9</issue><spage>820</spage><epage>825</epage><pages>820-825</pages><issn>0748-2337</issn><eissn>1477-0393</eissn><abstract>The aim of this study was to evaluate oxidative stress in workers who formulate organophosphate, synthetic pyrethroid and carbamate pesticides. In this survey, blood erythrocytes from a group of 94 pesticide-formulating workers (at least 5-years experience in pest-control in apple and cherry production) and 45 control subjects were examined for oxidative stress parameters. The control group was composed of 45 healthy people living in the same region with no exposure to pesticides. Lipid peroxidation level, catalase, superoxide dismutase and glutathione peroxidase activities in erythrocytes were analysed as biomarkers of oxidative stress. In addition, the acetylcholinesterase activity was measured as a biomarker of toxicity. Results indicated that chronic exposure to organophosphate, synthetic pyrethroid and carbamate pesticides were associated with increased activities of catalase, SOD and lipid peroxidation in erythrocytes (p < 0.05). Acetylcholinesterase activity did not show any significant differences between the two groups (p > 0.05). It is concluded that human chronic exposure to pesticides may result in stimulated antioxidant enzymes.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>21450927</pmid><doi>10.1177/0748233711399311</doi><tpages>6</tpages></addata></record> |
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| subjects | Acids Adult Agriculture - manpower Biomarkers Biomarkers - blood Carbamates - toxicity Cholinesterase Inhibitors - toxicity Chronic illnesses Enzymes Erythrocytes - enzymology Erythrocytes - metabolism Farmworkers Female Free radicals Fruit Human subjects Humans Insecticides - toxicity Lipid peroxidation Lipid Peroxidation - drug effects Lipids Male Malus Medicine Occupational Exposure Organophosphates - toxicity Oxidative stress Oxidative Stress - drug effects Oxidoreductases - blood Pesticides Pesticides - toxicity Prunus Pyrethrins - toxicity Questionnaires Time Factors Toxicity Toxicology Turkey Workers |
| title | Oxidative stress in the blood of farm workers following intensive pesticide exposure |
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