Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge
► We examined CTL immunodominance after SIV challenge in vaccinated macaques. ► Vaccine antigen-specific CTL responses were induced dominantly post-challenge. ► SIV non-vaccine antigen-specific CTL induction post-challenge was delayed. ► These imply an influence of vaccination on immunodominance pos...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2011-05, Vol.408 (4), p.615-619 |
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| creator | Takahara, Yusuke Matsuoka, Saori Kuwano, Tetsuya Tsukamoto, Tetsuo Yamamoto, Hiroyuki Ishii, Hiroshi Nakasone, Tadashi Takeda, Akiko Inoue, Makoto Iida, Akihiro Hara, Hiroto Shu, Tsugumine Hasegawa, Mamoru Sakawaki, Hiromi Horiike, Mariko Miura, Tomoyuki Igarashi, Tatsuhiko Naruse, Taeko K. Kimura, Akinori Matano, Tetsuro |
| description | ► We examined CTL immunodominance after SIV challenge in vaccinated macaques. ► Vaccine antigen-specific CTL responses were induced dominantly post-challenge. ► SIV non-vaccine antigen-specific CTL induction post-challenge was delayed. ► These imply an influence of vaccination on immunodominance post-viral exposure. ► This study provides insights into CTL antigen design in AIDS vaccine development.
Cytotoxic T lymphocyte (CTL) responses are crucial for the control of human and simian immunodeficiency virus (HIV and SIV) replication. A promising AIDS vaccine strategy is to induce CTL memory resulting in more effective CTL responses post-viral exposure compared to those in natural HIV infections. We previously developed a CTL-inducing vaccine and showed SIV control in some vaccinated rhesus macaques. These vaccine-based SIV controllers elicited vaccine antigen-specific CTL responses dominantly in the acute phase post-challenge. Here, we examined CTL responses post-challenge in those vaccinated animals that failed to control SIV replication. Unvaccinated rhesus macaques possessing the major histocompatibility complex class I haplotype 90-088-Ij dominantly elicited SIV non-Gag antigen-specific CTL responses after SIV challenge, while those induced with Gag-specific CTL memory by prophylactic vaccination failed to control SIV replication with dominant Gag-specific CTL responses in the acute phase, indicating dominant induction of vaccine antigen-specific CTL responses post-challenge even in non-controllers. Further analysis suggested that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine. |
| doi_str_mv | 10.1016/j.bbrc.2011.04.071 |
| format | Article |
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Cytotoxic T lymphocyte (CTL) responses are crucial for the control of human and simian immunodeficiency virus (HIV and SIV) replication. A promising AIDS vaccine strategy is to induce CTL memory resulting in more effective CTL responses post-viral exposure compared to those in natural HIV infections. We previously developed a CTL-inducing vaccine and showed SIV control in some vaccinated rhesus macaques. These vaccine-based SIV controllers elicited vaccine antigen-specific CTL responses dominantly in the acute phase post-challenge. Here, we examined CTL responses post-challenge in those vaccinated animals that failed to control SIV replication. Unvaccinated rhesus macaques possessing the major histocompatibility complex class I haplotype 90-088-Ij dominantly elicited SIV non-Gag antigen-specific CTL responses after SIV challenge, while those induced with Gag-specific CTL memory by prophylactic vaccination failed to control SIV replication with dominant Gag-specific CTL responses in the acute phase, indicating dominant induction of vaccine antigen-specific CTL responses post-challenge even in non-controllers. Further analysis suggested that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2011.04.071</identifier><identifier>PMID: 21531211</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - prevention & control ; AIDS vaccine ; AIDS Vaccines - immunology ; AIDS Vaccines - therapeutic use ; Animals ; Antigens, Viral - immunology ; CTL ; Cytotoxicity ; Haplotypes ; HIV ; Human immunodeficiency virus ; Humans ; Immunodominance ; Immunological memory ; Infection ; Lymphocytes T ; Macaca mulatta ; Major histocompatibility complex ; Memory cells ; Replication ; SAIDS Vaccines - immunology ; SAIDS Vaccines - therapeutic use ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - immunology ; SIV ; T-Lymphocytes, Cytotoxic - immunology ; Vaccination ; Vaccines</subject><ispartof>Biochemical and biophysical research communications, 2011-05, Vol.408 (4), p.615-619</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-3693298f399eb33fe5cd38ec8cadd05e4d16c87d599b53ff1e8ee5a0f7f4f743</citedby><cites>FETCH-LOGICAL-c387t-3693298f399eb33fe5cd38ec8cadd05e4d16c87d599b53ff1e8ee5a0f7f4f743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X11006565$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21531211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahara, Yusuke</creatorcontrib><creatorcontrib>Matsuoka, Saori</creatorcontrib><creatorcontrib>Kuwano, Tetsuya</creatorcontrib><creatorcontrib>Tsukamoto, Tetsuo</creatorcontrib><creatorcontrib>Yamamoto, Hiroyuki</creatorcontrib><creatorcontrib>Ishii, Hiroshi</creatorcontrib><creatorcontrib>Nakasone, Tadashi</creatorcontrib><creatorcontrib>Takeda, Akiko</creatorcontrib><creatorcontrib>Inoue, Makoto</creatorcontrib><creatorcontrib>Iida, Akihiro</creatorcontrib><creatorcontrib>Hara, Hiroto</creatorcontrib><creatorcontrib>Shu, Tsugumine</creatorcontrib><creatorcontrib>Hasegawa, Mamoru</creatorcontrib><creatorcontrib>Sakawaki, Hiromi</creatorcontrib><creatorcontrib>Horiike, Mariko</creatorcontrib><creatorcontrib>Miura, Tomoyuki</creatorcontrib><creatorcontrib>Igarashi, Tatsuhiko</creatorcontrib><creatorcontrib>Naruse, Taeko K.</creatorcontrib><creatorcontrib>Kimura, Akinori</creatorcontrib><creatorcontrib>Matano, Tetsuro</creatorcontrib><title>Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>► We examined CTL immunodominance after SIV challenge in vaccinated macaques. ► Vaccine antigen-specific CTL responses were induced dominantly post-challenge. ► SIV non-vaccine antigen-specific CTL induction post-challenge was delayed. ► These imply an influence of vaccination on immunodominance post-viral exposure. ► This study provides insights into CTL antigen design in AIDS vaccine development.
Cytotoxic T lymphocyte (CTL) responses are crucial for the control of human and simian immunodeficiency virus (HIV and SIV) replication. A promising AIDS vaccine strategy is to induce CTL memory resulting in more effective CTL responses post-viral exposure compared to those in natural HIV infections. We previously developed a CTL-inducing vaccine and showed SIV control in some vaccinated rhesus macaques. These vaccine-based SIV controllers elicited vaccine antigen-specific CTL responses dominantly in the acute phase post-challenge. Here, we examined CTL responses post-challenge in those vaccinated animals that failed to control SIV replication. Unvaccinated rhesus macaques possessing the major histocompatibility complex class I haplotype 90-088-Ij dominantly elicited SIV non-Gag antigen-specific CTL responses after SIV challenge, while those induced with Gag-specific CTL memory by prophylactic vaccination failed to control SIV replication with dominant Gag-specific CTL responses in the acute phase, indicating dominant induction of vaccine antigen-specific CTL responses post-challenge even in non-controllers. Further analysis suggested that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>AIDS vaccine</subject><subject>AIDS Vaccines - immunology</subject><subject>AIDS Vaccines - therapeutic use</subject><subject>Animals</subject><subject>Antigens, Viral - immunology</subject><subject>CTL</subject><subject>Cytotoxicity</subject><subject>Haplotypes</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunodominance</subject><subject>Immunological memory</subject><subject>Infection</subject><subject>Lymphocytes T</subject><subject>Macaca mulatta</subject><subject>Major histocompatibility complex</subject><subject>Memory cells</subject><subject>Replication</subject><subject>SAIDS Vaccines - immunology</subject><subject>SAIDS Vaccines - therapeutic use</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Simian immunodeficiency virus</subject><subject>Simian Immunodeficiency Virus - immunology</subject><subject>SIV</subject><subject>T-Lymphocytes, Cytotoxic - immunology</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtvHCEURlHkKN44-QMpIjpXM-ExD5DcRHZekqU0W6RDDFxsVjMwhpmVt8h_D5u1XSbVRZfzfcU9CH2gpKaEdp929TAkUzNCaU2amvT0FdpQIknFKGnO0IYQ0lVM0l_n6G3OO1LAppNv0DmjLaeM0g36fRMnH3RYsA92NYuPAUeH99oYHwCXD38HocozGO-8weawxCU-ltcWj4dpvo9lAzhBnmPIkLF2CySc_eR1wH6a1hAtlKSHYA5479OasbnX4wjhDt6h106PGd4_zQu0_fple_29uv357cf159vKcNEvFe8kZ1I4LiUMnDtojeUCjDDaWtJCY2lnRG9bKYeWO0dBALSauN41rm_4Bbo81c4pPqyQFzX5bGAcdYC4ZiUJ440QrP0vKTrBe9HRrpDsRJoUc07g1Jz8pNNBUaKOetROHfWoox5FGlX0lNDHp_p1mMC-RJ59FODqBEC5xt5DUvnv5cD6BGZRNvp_9f8BG7yksA</recordid><startdate>20110520</startdate><enddate>20110520</enddate><creator>Takahara, Yusuke</creator><creator>Matsuoka, Saori</creator><creator>Kuwano, Tetsuya</creator><creator>Tsukamoto, Tetsuo</creator><creator>Yamamoto, Hiroyuki</creator><creator>Ishii, Hiroshi</creator><creator>Nakasone, Tadashi</creator><creator>Takeda, Akiko</creator><creator>Inoue, Makoto</creator><creator>Iida, Akihiro</creator><creator>Hara, Hiroto</creator><creator>Shu, Tsugumine</creator><creator>Hasegawa, Mamoru</creator><creator>Sakawaki, Hiromi</creator><creator>Horiike, Mariko</creator><creator>Miura, Tomoyuki</creator><creator>Igarashi, Tatsuhiko</creator><creator>Naruse, Taeko K.</creator><creator>Kimura, Akinori</creator><creator>Matano, Tetsuro</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20110520</creationdate><title>Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge</title><author>Takahara, Yusuke ; Matsuoka, Saori ; Kuwano, Tetsuya ; Tsukamoto, Tetsuo ; Yamamoto, Hiroyuki ; Ishii, Hiroshi ; Nakasone, Tadashi ; Takeda, Akiko ; Inoue, Makoto ; Iida, Akihiro ; Hara, Hiroto ; Shu, Tsugumine ; Hasegawa, Mamoru ; Sakawaki, Hiromi ; Horiike, Mariko ; Miura, Tomoyuki ; Igarashi, Tatsuhiko ; Naruse, Taeko K. ; Kimura, Akinori ; Matano, Tetsuro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-3693298f399eb33fe5cd38ec8cadd05e4d16c87d599b53ff1e8ee5a0f7f4f743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>AIDS vaccine</topic><topic>AIDS Vaccines - immunology</topic><topic>AIDS Vaccines - therapeutic use</topic><topic>Animals</topic><topic>Antigens, Viral - immunology</topic><topic>CTL</topic><topic>Cytotoxicity</topic><topic>Haplotypes</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunodominance</topic><topic>Immunological memory</topic><topic>Infection</topic><topic>Lymphocytes T</topic><topic>Macaca mulatta</topic><topic>Major histocompatibility complex</topic><topic>Memory cells</topic><topic>Replication</topic><topic>SAIDS Vaccines - immunology</topic><topic>SAIDS Vaccines - therapeutic use</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Simian immunodeficiency virus</topic><topic>Simian Immunodeficiency Virus - immunology</topic><topic>SIV</topic><topic>T-Lymphocytes, Cytotoxic - immunology</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahara, Yusuke</creatorcontrib><creatorcontrib>Matsuoka, Saori</creatorcontrib><creatorcontrib>Kuwano, Tetsuya</creatorcontrib><creatorcontrib>Tsukamoto, Tetsuo</creatorcontrib><creatorcontrib>Yamamoto, Hiroyuki</creatorcontrib><creatorcontrib>Ishii, Hiroshi</creatorcontrib><creatorcontrib>Nakasone, Tadashi</creatorcontrib><creatorcontrib>Takeda, Akiko</creatorcontrib><creatorcontrib>Inoue, Makoto</creatorcontrib><creatorcontrib>Iida, Akihiro</creatorcontrib><creatorcontrib>Hara, Hiroto</creatorcontrib><creatorcontrib>Shu, Tsugumine</creatorcontrib><creatorcontrib>Hasegawa, Mamoru</creatorcontrib><creatorcontrib>Sakawaki, Hiromi</creatorcontrib><creatorcontrib>Horiike, Mariko</creatorcontrib><creatorcontrib>Miura, Tomoyuki</creatorcontrib><creatorcontrib>Igarashi, Tatsuhiko</creatorcontrib><creatorcontrib>Naruse, Taeko K.</creatorcontrib><creatorcontrib>Kimura, Akinori</creatorcontrib><creatorcontrib>Matano, Tetsuro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahara, Yusuke</au><au>Matsuoka, Saori</au><au>Kuwano, Tetsuya</au><au>Tsukamoto, Tetsuo</au><au>Yamamoto, Hiroyuki</au><au>Ishii, Hiroshi</au><au>Nakasone, Tadashi</au><au>Takeda, Akiko</au><au>Inoue, Makoto</au><au>Iida, Akihiro</au><au>Hara, Hiroto</au><au>Shu, Tsugumine</au><au>Hasegawa, Mamoru</au><au>Sakawaki, Hiromi</au><au>Horiike, Mariko</au><au>Miura, Tomoyuki</au><au>Igarashi, Tatsuhiko</au><au>Naruse, Taeko K.</au><au>Kimura, Akinori</au><au>Matano, Tetsuro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2011-05-20</date><risdate>2011</risdate><volume>408</volume><issue>4</issue><spage>615</spage><epage>619</epage><pages>615-619</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>► We examined CTL immunodominance after SIV challenge in vaccinated macaques. ► Vaccine antigen-specific CTL responses were induced dominantly post-challenge. ► SIV non-vaccine antigen-specific CTL induction post-challenge was delayed. ► These imply an influence of vaccination on immunodominance post-viral exposure. ► This study provides insights into CTL antigen design in AIDS vaccine development.
Cytotoxic T lymphocyte (CTL) responses are crucial for the control of human and simian immunodeficiency virus (HIV and SIV) replication. A promising AIDS vaccine strategy is to induce CTL memory resulting in more effective CTL responses post-viral exposure compared to those in natural HIV infections. We previously developed a CTL-inducing vaccine and showed SIV control in some vaccinated rhesus macaques. These vaccine-based SIV controllers elicited vaccine antigen-specific CTL responses dominantly in the acute phase post-challenge. Here, we examined CTL responses post-challenge in those vaccinated animals that failed to control SIV replication. Unvaccinated rhesus macaques possessing the major histocompatibility complex class I haplotype 90-088-Ij dominantly elicited SIV non-Gag antigen-specific CTL responses after SIV challenge, while those induced with Gag-specific CTL memory by prophylactic vaccination failed to control SIV replication with dominant Gag-specific CTL responses in the acute phase, indicating dominant induction of vaccine antigen-specific CTL responses post-challenge even in non-controllers. Further analysis suggested that prophylactic vaccination results in dominant induction of vaccine antigen-specific CTL responses post-viral exposure but delays SIV non-vaccine antigen-specific CTL responses. These results imply a significant influence of prophylactic vaccination on CTL immunodominance post-viral exposure, providing insights into antigen design in development of a CTL-inducing AIDS vaccine.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21531211</pmid><doi>10.1016/j.bbrc.2011.04.071</doi><tpages>5</tpages></addata></record> |
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| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - prevention & control AIDS vaccine AIDS Vaccines - immunology AIDS Vaccines - therapeutic use Animals Antigens, Viral - immunology CTL Cytotoxicity Haplotypes HIV Human immunodeficiency virus Humans Immunodominance Immunological memory Infection Lymphocytes T Macaca mulatta Major histocompatibility complex Memory cells Replication SAIDS Vaccines - immunology SAIDS Vaccines - therapeutic use Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology SIV T-Lymphocytes, Cytotoxic - immunology Vaccination Vaccines |
| title | Dominant induction of vaccine antigen-specific cytotoxic T lymphocyte responses after simian immunodeficiency virus challenge |
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