Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection
The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT. Ten normal liver controls and 44 liver tumor patients who under...
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| Veröffentlicht in: | Annals of nuclear medicine 2003-09, Vol.17 (6), p.489-493 |
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| creator | Li, Xiao-Feng Taki, Junichi Kinuya, Seigo Higuchi, Takahiro Konishi, Shota Hwang, Eui-Hyo Shuke, Noriyuki Nakajima, Kenichi Tonami, Norihisa |
| description | The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT.
Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 +/- 3 d before (pre-operative) and 34 +/- 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated.
Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001).
ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume. |
| doi_str_mv | 10.1007/BF03006440 |
| format | Article |
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Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 +/- 3 d before (pre-operative) and 34 +/- 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated.
Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001).
ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/BF03006440</identifier><identifier>PMID: 14575385</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Asialoglycoprotein Receptor - metabolism ; Biomarkers, Tumor - metabolism ; Correlation ; Female ; Hepatectomy ; Hepatectomy - methods ; Human serum albumin ; Humans ; Liver ; Liver - diagnostic imaging ; Liver - metabolism ; Liver - surgery ; Liver cancer ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - metabolism ; Liver Neoplasms - surgery ; Male ; Mathematical analysis ; Metabolic Clearance Rate ; Middle Aged ; Postoperative Care ; Preoperative Care ; Radiopharmaceuticals - pharmacokinetics ; Receptors ; Serum albumin ; Technetium Tc 99m Aggregated Albumin - pharmacokinetics ; Technetium Tc 99m Pentetate - pharmacokinetics ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon - methods ; Treatment Outcome ; Tumors</subject><ispartof>Annals of nuclear medicine, 2003-09, Vol.17 (6), p.489-493</ispartof><rights>Springer 2003</rights><rights>Springer 2003.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-daf74f804daaa391150469a080981548bc0787ab79987af3445cfd787c05dce53</citedby><cites>FETCH-LOGICAL-c454t-daf74f804daaa391150469a080981548bc0787ab79987af3445cfd787c05dce53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14575385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xiao-Feng</creatorcontrib><creatorcontrib>Taki, Junichi</creatorcontrib><creatorcontrib>Kinuya, Seigo</creatorcontrib><creatorcontrib>Higuchi, Takahiro</creatorcontrib><creatorcontrib>Konishi, Shota</creatorcontrib><creatorcontrib>Hwang, Eui-Hyo</creatorcontrib><creatorcontrib>Shuke, Noriyuki</creatorcontrib><creatorcontrib>Nakajima, Kenichi</creatorcontrib><creatorcontrib>Tonami, Norihisa</creatorcontrib><title>Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT.
Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 +/- 3 d before (pre-operative) and 34 +/- 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated.
Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001).
ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.</description><subject>Asialoglycoprotein Receptor - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Correlation</subject><subject>Female</subject><subject>Hepatectomy</subject><subject>Hepatectomy - methods</subject><subject>Human serum albumin</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - metabolism</subject><subject>Liver - surgery</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Mathematical analysis</subject><subject>Metabolic Clearance Rate</subject><subject>Middle Aged</subject><subject>Postoperative Care</subject><subject>Preoperative Care</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Receptors</subject><subject>Serum albumin</subject><subject>Technetium Tc 99m Aggregated Albumin - pharmacokinetics</subject><subject>Technetium Tc 99m Pentetate - pharmacokinetics</subject><subject>Tissue Distribution</subject><subject>Tomography, Emission-Computed, Single-Photon - methods</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFksGKFDEQhoMo7rh68QEkKCgIrZWk0kmO6-KqsOBFz00mXb1m6emMSVqYtzfDDiwI6qlC6uNL_aQYey7gnQAw7z9cgQLoEeEB2wjbY9ejUg_ZBpzAzghrztiTUm4BpNVWPmZnArXRyuoNqxcl-jndzIeQ9jlVigvPFGhfU-YhLYGWmn2NaeGtU9ddyt2WfI7LDZ_jL8qF-2XksRY--Uq8teYD91OlzOsPipkXCs3VHmne47mpnrJHk58LPTvVc_b96uO3y8_d9ddPXy4vrruAGms3-sngZAFH771yQmjA3nmw4KzQaLcBjDV-a5xrZVKIOkxjuwqgx0BanbM3d96W7OdKpQ67WALNs18orWVwIBVa7E0jX_-TNEKBdKj_C0ohpLUoGvjqD_A2rXlpcQfZRpRaOq0a9fKv1DGudb1s0Ns7KORUSqZp2Oe48_kwCBiOGzDcb0CDX5yM63ZH4z16-nL1G43PqsQ</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>Li, Xiao-Feng</creator><creator>Taki, Junichi</creator><creator>Kinuya, Seigo</creator><creator>Higuchi, Takahiro</creator><creator>Konishi, Shota</creator><creator>Hwang, Eui-Hyo</creator><creator>Shuke, Noriyuki</creator><creator>Nakajima, Kenichi</creator><creator>Tonami, Norihisa</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection</title><author>Li, Xiao-Feng ; Taki, Junichi ; Kinuya, Seigo ; Higuchi, Takahiro ; Konishi, Shota ; Hwang, Eui-Hyo ; Shuke, Noriyuki ; Nakajima, Kenichi ; Tonami, Norihisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-daf74f804daaa391150469a080981548bc0787ab79987af3445cfd787c05dce53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Asialoglycoprotein Receptor - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Correlation</topic><topic>Female</topic><topic>Hepatectomy</topic><topic>Hepatectomy - methods</topic><topic>Human serum albumin</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - metabolism</topic><topic>Liver - surgery</topic><topic>Liver cancer</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Mathematical analysis</topic><topic>Metabolic Clearance Rate</topic><topic>Middle Aged</topic><topic>Postoperative Care</topic><topic>Preoperative Care</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Receptors</topic><topic>Serum albumin</topic><topic>Technetium Tc 99m Aggregated Albumin - pharmacokinetics</topic><topic>Technetium Tc 99m Pentetate - pharmacokinetics</topic><topic>Tissue Distribution</topic><topic>Tomography, Emission-Computed, Single-Photon - methods</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiao-Feng</creatorcontrib><creatorcontrib>Taki, Junichi</creatorcontrib><creatorcontrib>Kinuya, Seigo</creatorcontrib><creatorcontrib>Higuchi, Takahiro</creatorcontrib><creatorcontrib>Konishi, Shota</creatorcontrib><creatorcontrib>Hwang, Eui-Hyo</creatorcontrib><creatorcontrib>Shuke, Noriyuki</creatorcontrib><creatorcontrib>Nakajima, Kenichi</creatorcontrib><creatorcontrib>Tonami, Norihisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiao-Feng</au><au>Taki, Junichi</au><au>Kinuya, Seigo</au><au>Higuchi, Takahiro</au><au>Konishi, Shota</au><au>Hwang, Eui-Hyo</au><au>Shuke, Noriyuki</au><au>Nakajima, Kenichi</au><au>Tonami, Norihisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>17</volume><issue>6</issue><spage>489</spage><epage>493</epage><pages>489-493</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>The aim of the present study was to investigate asialoglycoprotein receptor (ASGP-R) status in tumor-bearing livers and early after their sectorial resection employing 99mTc-DTPA-galactosyl human serum albumin (99mTc-GSA) dynamic SPECT.
Ten normal liver controls and 44 liver tumor patients who underwent sectorial hepatectomy were included in the study. 99mTc-GSA dynamic SPECT study was performed 7 +/- 3 d before (pre-operative) and 34 +/- 13 d after surgery (post-operative) in liver tumour patients. Pre- and post-operative parameters including hepatic functional volume and 99mTc-GSA clearance of unit hepatic functional volume, representing ASGP-R concentration, were measured. The sum of functional volume of the sectors uninvolved in hepatectomy was defined as residual functional volume. Subsequently, post-operative change in functional volume (the ratio of post-operative to residual functional volume), post-operative change in 99mTc-GSA clearance of unit hepatic functional volume (the ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume) and percent resection of functional volume were calculated.
Pre-operative 99mTc-GSA clearance of unit hepatic functional volume in tumor-bearing livers was significantly lower than that in non-tumor bearing control liver. The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume showed marked variation from 0.57 to 2.14, which negatively correlated with the percent resection of functional volume (r = -0.58, p < 0.0001). The ratio of post- to pre-operative 99mTc-GSA clearance of unit hepatic functional volume exhibited a negative correlation with the ratio of post-operative to estimated residual functional volume (r = -0.67, p < 0.0001).
ASGP-R concentration is reduced in the presence of liver tumor. ASGP-R concentration reveals variable changes early after sectorial resection; the change negatively correlates with percent resection of hepatic functional volume. Post-operative change in ASGP-R concentration negatively correlates with change in functional volume.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>14575385</pmid><doi>10.1007/BF03006440</doi><tpages>5</tpages></addata></record> |
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| subjects | Asialoglycoprotein Receptor - metabolism Biomarkers, Tumor - metabolism Correlation Female Hepatectomy Hepatectomy - methods Human serum albumin Humans Liver Liver - diagnostic imaging Liver - metabolism Liver - surgery Liver cancer Liver Neoplasms - diagnostic imaging Liver Neoplasms - metabolism Liver Neoplasms - surgery Male Mathematical analysis Metabolic Clearance Rate Middle Aged Postoperative Care Preoperative Care Radiopharmaceuticals - pharmacokinetics Receptors Serum albumin Technetium Tc 99m Aggregated Albumin - pharmacokinetics Technetium Tc 99m Pentetate - pharmacokinetics Tissue Distribution Tomography, Emission-Computed, Single-Photon - methods Treatment Outcome Tumors |
| title | Asialoglycoprotein receptor concentration in tumor-bearing livers and its fate early after their sectorial resection |
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