Stimulated osteoblastic proliferation by mesoporous silica xerogel with high specific surface area
Specific surface area is a critical parameter of mesoporous silica-based biomaterials, however, little is known about its effects on osteoblast responses in vitro. In the present study, mesoporous silica xerogels (MSXs) with different surface area (401, 647 and 810 m 2 /g, respectively) were synthes...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2011-03, Vol.22 (3), p.731-739 |
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| creator | Zhou, Huanjun Wu, Xiaohui Wei, Jie Lu, Xun Zhang, Shuo Shi, Jianlin Liu, Changsheng |
| description | Specific surface area is a critical parameter of mesoporous silica-based biomaterials, however, little is known about its effects on osteoblast responses in vitro. In the present study, mesoporous silica xerogels (MSXs) with different surface area (401, 647 and 810 m
2
/g, respectively) were synthesized by a sol–gel process. Surface silanol contents decreased with the increase of surface area with which protein adsorption capability positively correlated. And the apatite-like surface seemed to form faster on MSXs with higher surface area determined by XRD analysis. Using MG63 osteoblast-like cells as models, it was found that cell proliferations were promoted on MSXs with higher surface area, based on the premise that the effects of Si released from materials on osteoblast viability were excluded by real-time Transwell
®
assay. RT-PCR results indicated cell adhesion-related integrin subunits α5 were up-regulated by higher surface area at day 1, which was further confirmed by flow cytometry analysis. The data suggest that increasing SSA of MSXs could promote surface cellular affinity by adsorbing serum proteins and accelerating apatite-like layer formation, which results in promoted osteoblastic proliferation via integrin subunit α5 at initial adhesion stage. Regulating SSA, an effective approach in designing mesoporous silica-based materials, provides an alternative method to obtain desirable tissue-response in bone regeneration and drug-delivery system. |
| doi_str_mv | 10.1007/s10856-011-4239-1 |
| format | Article |
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2
/g, respectively) were synthesized by a sol–gel process. Surface silanol contents decreased with the increase of surface area with which protein adsorption capability positively correlated. And the apatite-like surface seemed to form faster on MSXs with higher surface area determined by XRD analysis. Using MG63 osteoblast-like cells as models, it was found that cell proliferations were promoted on MSXs with higher surface area, based on the premise that the effects of Si released from materials on osteoblast viability were excluded by real-time Transwell
®
assay. RT-PCR results indicated cell adhesion-related integrin subunits α5 were up-regulated by higher surface area at day 1, which was further confirmed by flow cytometry analysis. The data suggest that increasing SSA of MSXs could promote surface cellular affinity by adsorbing serum proteins and accelerating apatite-like layer formation, which results in promoted osteoblastic proliferation via integrin subunit α5 at initial adhesion stage. Regulating SSA, an effective approach in designing mesoporous silica-based materials, provides an alternative method to obtain desirable tissue-response in bone regeneration and drug-delivery system.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-011-4239-1</identifier><identifier>PMID: 21287245</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adsorption ; Apatites - chemistry ; Biocompatibility ; Biological and medical sciences ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Bone Regeneration ; Cell Proliferation ; Cell Survival ; Cells ; Cells, Cultured ; Ceramics ; Chemistry and Materials Science ; Composites ; Drug Delivery Systems ; Flow Cytometry - methods ; Glass ; Hydrogen-Ion Concentration ; Integrin alpha5 - metabolism ; Materials Science ; Mathematical models ; Medical sciences ; Natural Materials ; Osteoblasts - cytology ; Polymer Sciences ; Porosity ; Porous materials ; Regenerative Medicine/Tissue Engineering ; Reverse Transcriptase Polymerase Chain Reaction ; Silanes - chemistry ; Silica ; Silicon dioxide ; Silicon Dioxide - chemistry ; Specific surface ; Surface area ; Surface chemistry ; Surfaces and Interfaces ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Thermogravimetry - methods ; Thin Films ; X-Ray Diffraction ; Xerogels</subject><ispartof>Journal of materials science. Materials in medicine, 2011-03, Vol.22 (3), p.731-739</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-2180aec868ff5650b4758f90791d6e1956f6d59de463ba41aa5a801e5039ef113</citedby><cites>FETCH-LOGICAL-c465t-2180aec868ff5650b4758f90791d6e1956f6d59de463ba41aa5a801e5039ef113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10856-011-4239-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10856-011-4239-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24178078$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21287245$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Huanjun</creatorcontrib><creatorcontrib>Wu, Xiaohui</creatorcontrib><creatorcontrib>Wei, Jie</creatorcontrib><creatorcontrib>Lu, Xun</creatorcontrib><creatorcontrib>Zhang, Shuo</creatorcontrib><creatorcontrib>Shi, Jianlin</creatorcontrib><creatorcontrib>Liu, Changsheng</creatorcontrib><title>Stimulated osteoblastic proliferation by mesoporous silica xerogel with high specific surface area</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Specific surface area is a critical parameter of mesoporous silica-based biomaterials, however, little is known about its effects on osteoblast responses in vitro. In the present study, mesoporous silica xerogels (MSXs) with different surface area (401, 647 and 810 m
2
/g, respectively) were synthesized by a sol–gel process. Surface silanol contents decreased with the increase of surface area with which protein adsorption capability positively correlated. And the apatite-like surface seemed to form faster on MSXs with higher surface area determined by XRD analysis. Using MG63 osteoblast-like cells as models, it was found that cell proliferations were promoted on MSXs with higher surface area, based on the premise that the effects of Si released from materials on osteoblast viability were excluded by real-time Transwell
®
assay. RT-PCR results indicated cell adhesion-related integrin subunits α5 were up-regulated by higher surface area at day 1, which was further confirmed by flow cytometry analysis. The data suggest that increasing SSA of MSXs could promote surface cellular affinity by adsorbing serum proteins and accelerating apatite-like layer formation, which results in promoted osteoblastic proliferation via integrin subunit α5 at initial adhesion stage. Regulating SSA, an effective approach in designing mesoporous silica-based materials, provides an alternative method to obtain desirable tissue-response in bone regeneration and drug-delivery system.</description><subject>Adsorption</subject><subject>Apatites - chemistry</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Bone Regeneration</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Cells</subject><subject>Cells, Cultured</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Drug Delivery Systems</subject><subject>Flow Cytometry - methods</subject><subject>Glass</subject><subject>Hydrogen-Ion Concentration</subject><subject>Integrin alpha5 - metabolism</subject><subject>Materials Science</subject><subject>Mathematical models</subject><subject>Medical sciences</subject><subject>Natural Materials</subject><subject>Osteoblasts - cytology</subject><subject>Polymer Sciences</subject><subject>Porosity</subject><subject>Porous materials</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Silanes - chemistry</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>Specific surface</subject><subject>Surface area</subject><subject>Surface chemistry</subject><subject>Surfaces and Interfaces</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Huanjun</au><au>Wu, Xiaohui</au><au>Wei, Jie</au><au>Lu, Xun</au><au>Zhang, Shuo</au><au>Shi, Jianlin</au><au>Liu, Changsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulated osteoblastic proliferation by mesoporous silica xerogel with high specific surface area</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>22</volume><issue>3</issue><spage>731</spage><epage>739</epage><pages>731-739</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Specific surface area is a critical parameter of mesoporous silica-based biomaterials, however, little is known about its effects on osteoblast responses in vitro. In the present study, mesoporous silica xerogels (MSXs) with different surface area (401, 647 and 810 m
2
/g, respectively) were synthesized by a sol–gel process. Surface silanol contents decreased with the increase of surface area with which protein adsorption capability positively correlated. And the apatite-like surface seemed to form faster on MSXs with higher surface area determined by XRD analysis. Using MG63 osteoblast-like cells as models, it was found that cell proliferations were promoted on MSXs with higher surface area, based on the premise that the effects of Si released from materials on osteoblast viability were excluded by real-time Transwell
®
assay. RT-PCR results indicated cell adhesion-related integrin subunits α5 were up-regulated by higher surface area at day 1, which was further confirmed by flow cytometry analysis. The data suggest that increasing SSA of MSXs could promote surface cellular affinity by adsorbing serum proteins and accelerating apatite-like layer formation, which results in promoted osteoblastic proliferation via integrin subunit α5 at initial adhesion stage. Regulating SSA, an effective approach in designing mesoporous silica-based materials, provides an alternative method to obtain desirable tissue-response in bone regeneration and drug-delivery system.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>21287245</pmid><doi>10.1007/s10856-011-4239-1</doi><tpages>9</tpages></addata></record> |
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| subjects | Adsorption Apatites - chemistry Biocompatibility Biological and medical sciences Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Bone Regeneration Cell Proliferation Cell Survival Cells Cells, Cultured Ceramics Chemistry and Materials Science Composites Drug Delivery Systems Flow Cytometry - methods Glass Hydrogen-Ion Concentration Integrin alpha5 - metabolism Materials Science Mathematical models Medical sciences Natural Materials Osteoblasts - cytology Polymer Sciences Porosity Porous materials Regenerative Medicine/Tissue Engineering Reverse Transcriptase Polymerase Chain Reaction Silanes - chemistry Silica Silicon dioxide Silicon Dioxide - chemistry Specific surface Surface area Surface chemistry Surfaces and Interfaces Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Thermogravimetry - methods Thin Films X-Ray Diffraction Xerogels |
| title | Stimulated osteoblastic proliferation by mesoporous silica xerogel with high specific surface area |
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