Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract
. The anti-pyretic activity of a standardized methanol/water (50/50) extract of Orthosiphon stamineus Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and...
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| Veröffentlicht in: | Inflammopharmacology 2009-02, Vol.17 (1), p.50-54 |
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| creator | Yam, M. F. Ang, L. F. Basir, R. Salman, I. M. Ameer, O. Z. Asmawi, M. Z. |
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The anti-pyretic activity of a standardized methanol/water (50/50) extract of
Orthosiphon stamineus
Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD
50
of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity. |
| doi_str_mv | 10.1007/s10787-008-8038-3 |
| format | Article |
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The anti-pyretic activity of a standardized methanol/water (50/50) extract of
Orthosiphon stamineus
Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD
50
of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity.</description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-008-8038-3</identifier><identifier>PMID: 19127348</identifier><language>eng</language><publisher>Basel: Birkhäuser-Verlag</publisher><subject>Acetaminophen - pharmacology ; Allergology ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - isolation & purification ; Analgesics, Non-Narcotic - toxicity ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Body Temperature - drug effects ; Chromatography, High Pressure Liquid ; Dermatology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Female ; Fever - drug therapy ; Gastroenterology ; Immunology ; Lethal Dose 50 ; Male ; Orthosiphon - chemistry ; Pharmacology/Toxicology ; Plant Extracts - administration & dosage ; Plant Extracts - toxicity ; Plant Leaves ; Rats ; Rats, Sprague-Dawley ; Rheumatology ; Short Communication ; Time Factors ; Toxicity Tests, Acute</subject><ispartof>Inflammopharmacology, 2009-02, Vol.17 (1), p.50-54</ispartof><rights>Birkhäuser Verlag, Basel 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3323-e6d33fe9c91e4c01cd98410b201a6b2878fd97d310f328d6e3343207d5d53ca83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10787-008-8038-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10787-008-8038-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19127348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yam, M. F.</creatorcontrib><creatorcontrib>Ang, L. F.</creatorcontrib><creatorcontrib>Basir, R.</creatorcontrib><creatorcontrib>Salman, I. M.</creatorcontrib><creatorcontrib>Ameer, O. Z.</creatorcontrib><creatorcontrib>Asmawi, M. Z.</creatorcontrib><title>Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>.
The anti-pyretic activity of a standardized methanol/water (50/50) extract of
Orthosiphon stamineus
Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD
50
of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity.</description><subject>Acetaminophen - pharmacology</subject><subject>Allergology</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - isolation & purification</subject><subject>Analgesics, Non-Narcotic - toxicity</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Temperature - drug effects</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dermatology</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fever - drug therapy</subject><subject>Gastroenterology</subject><subject>Immunology</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Orthosiphon - chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - toxicity</subject><subject>Plant Leaves</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rheumatology</subject><subject>Short Communication</subject><subject>Time Factors</subject><subject>Toxicity Tests, Acute</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAQhi1UVBbaB-ilyo2TYexJHPtIEbRISFzorZLltSdsUDYJtlNBnx6vdiVuPY1G8_2_NB9j3wRcCID2MglodcsBNNeAmuMRW4lGad4o0J_YCoxseK2MPGGnKT0DgGqV-cxOhBGyxVqv2J-bv25YXO6nsZq6Km-ocmPu-fwWKfe-mqdMZXfD7voQ82ZK_bwpcMpu24-0pOpHATa7fQwuhv4fhYpec3Q-f2HHnRsSfT3MM_b79ubx-he_f_h5d311zz2iRE4qIHZkvBFUexA-GF0LWEsQTq2lbnUXTBtQQIdSB0WINUpoQxMa9E7jGTvf985xelkoZbvtk6dhcCNNS7IGJNaq1qKQYk_6OKUUqbNz7LcuvlkBdufU7p3a4tTunFosme-H9mW9pfCROEgsgNwDqZzGJ4r2eVriWD7-T-s7M9OClA</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Yam, M. F.</creator><creator>Ang, L. F.</creator><creator>Basir, R.</creator><creator>Salman, I. M.</creator><creator>Ameer, O. Z.</creator><creator>Asmawi, M. Z.</creator><general>Birkhäuser-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200902</creationdate><title>Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract</title><author>Yam, M. F. ; Ang, L. F. ; Basir, R. ; Salman, I. M. ; Ameer, O. Z. ; Asmawi, M. Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3323-e6d33fe9c91e4c01cd98410b201a6b2878fd97d310f328d6e3343207d5d53ca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetaminophen - pharmacology</topic><topic>Allergology</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - isolation & purification</topic><topic>Analgesics, Non-Narcotic - toxicity</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Temperature - drug effects</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dermatology</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fever - drug therapy</topic><topic>Gastroenterology</topic><topic>Immunology</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Orthosiphon - chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - toxicity</topic><topic>Plant Leaves</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rheumatology</topic><topic>Short Communication</topic><topic>Time Factors</topic><topic>Toxicity Tests, Acute</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yam, M. F.</creatorcontrib><creatorcontrib>Ang, L. F.</creatorcontrib><creatorcontrib>Basir, R.</creatorcontrib><creatorcontrib>Salman, I. M.</creatorcontrib><creatorcontrib>Ameer, O. Z.</creatorcontrib><creatorcontrib>Asmawi, M. Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yam, M. F.</au><au>Ang, L. F.</au><au>Basir, R.</au><au>Salman, I. M.</au><au>Ameer, O. Z.</au><au>Asmawi, M. Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2009-02</date><risdate>2009</risdate><volume>17</volume><issue>1</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>0925-4692</issn><eissn>1568-5608</eissn><abstract>.
The anti-pyretic activity of a standardized methanol/water (50/50) extract of
Orthosiphon stamineus
Benth. (SEOS) was investigated for its effect on normal body temperature and yeast-induced pyrexia in Sprague Dawley (SD) rats. The SEOS showed no effect on normal body temperature. Doses of 500 and 1000 mg/kg body weight of SEOS significantly reduced the yeast-induced elevation in body temperature. This effect persisted up to 4 h following the administration of the extract. The anti-pyretic effect of SEOS was comparable with that of paracetamol (acetaminophen in U.S) (150 mg/kg p.o.), a standard anti-pyretic agent. HPLC study revealed that rosmarinic acid, sinensetin, eupatorin and tetramethoxyflavone were present in SEOS in the amounts of 7.58 %, 0.2 %, 0.34 % and 0.24 % respectively. The LD
50
of the extract in rats was higher than 5000 mg/kg body weight. Therefore, the present study ascertained that SEOS possesses a significant anti-pyretic activity.</abstract><cop>Basel</cop><pub>Birkhäuser-Verlag</pub><pmid>19127348</pmid><doi>10.1007/s10787-008-8038-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetaminophen - pharmacology Allergology Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - isolation & purification Analgesics, Non-Narcotic - toxicity Animals Biomedical and Life Sciences Biomedicine Body Temperature - drug effects Chromatography, High Pressure Liquid Dermatology Disease Models, Animal Dose-Response Relationship, Drug Female Fever - drug therapy Gastroenterology Immunology Lethal Dose 50 Male Orthosiphon - chemistry Pharmacology/Toxicology Plant Extracts - administration & dosage Plant Extracts - toxicity Plant Leaves Rats Rats, Sprague-Dawley Rheumatology Short Communication Time Factors Toxicity Tests, Acute |
| title | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract |
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