Autoimmunity against human tropomyosin isoforms in ulcerative colitis: Localization of specific human tropomyosin isoforms in the intestine and extraintestinal organs

Background: Tropomyosins (TMs) are microfilament cytoskeletal proteins, and 5 major human TM isoforms (hTM1‐5) are described. hTMs, particularly isoform 5 (hTM5), is capable of inducing autoantibodies and T‐cell response in ulcerative colitis (UC). However, cellular localization of hTM isoforms in t...

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Veröffentlicht in:	Inflammatory bowel diseases 2006-11, Vol.12 (11), p.1036-1043
Hauptverfasser:	Mirza, Zafar K., Sastri, Bhagyalakshmi, Lin, Jim J.‐C., Amenta, Peter S., Das, Kiron M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibody Specificity Autoantibodies Autoantibodies - biosynthesis Autoantibodies - blood Autoimmunity Basement membranes Bile duct Blood vessels Colitis, Ulcerative - immunology Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon Cytoskeleton Effector cells Endothelial cells Epithelial cells Epithelium Esophagus extraintestinal manifestations Eye Gallbladder Humans Immunohistochemistry Immunopathogenesis Immunoreactivity Inflammatory bowel diseases Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Liver Lung Lymphocytes T Microfilaments Monoclonal antibodies Pancreas Protein Isoforms Skin Small intestine Smooth muscle Tropomyosin Tropomyosin - immunology Tropomyosin - metabolism Ulcerative colitis
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