Correlation between cyclical epithelial barrier dysfunction and bacterial translocation in the relapses of intestinal inflammation

Background: Although several factors have been implicated in the pathogenesis of inflammatory bowel disease (IBD), the mechanisms underlying the recurrent relapses have not yet been clarified. We hypothesized that epithelial barrier dysfunction, associated with intestinal motor disturbances, could p...

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Veröffentlicht in:	Inflammatory bowel diseases 2006-09, Vol.12 (9), p.843-852
Hauptverfasser:	Porras, Monica, Martín, Maria Teresa, Yang, Ping‐Chang, Jury, Jennifer, Perdue, Mary H., Vergara, Patri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria bacterial translocation Bacterial Translocation - physiology Biological Transport Conductance Electron microscopy Electrophysiology - methods endosomes Enteritis Enterocytes Enterocytes - immunology Enterocytes - metabolism Enterocytes - microbiology Enterocytes - pathology Epithelium - physiology Epithelium - ultrastructure Immunity, Mucosal Indomethacin Indomethacin - pharmacology inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - immunology Inflammatory Bowel Diseases - microbiology Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - physiopathology Intestine Intestine, Small - drug effects Intestine, Small - immunology Intestine, Small - microbiology Intestine, Small - physiopathology Leukocytes - cytology Leukocytes - drug effects Lymph nodes Male Mast Cells - immunology Mast Cells - pathology Mucosa mucosal permeability Oscillations Permeability Peroxidase - biosynthesis Rats Rats, Sprague-Dawley Recurrence Short-circuit current Translocation
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