Proanthocyanidin-enriched extract from Myrothamnus flabellifolia Welw. exerts antiviral activity against herpes simplex virus type 1 by inhibition of viral adsorption and penetration

Extracts from the aerial parts of the South African resurrection plant Myrothamnus flabellifolia Welw. have been used traditionally against infections of the upper respiratory tract and skin diseases. A polyphenol-enriched extract was investigated for potential antiviral effects against herpes simpl...

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Veröffentlicht in:	Journal of ethnopharmacology 2011-03, Vol.134 (2), p.468-474
Hauptverfasser:	Gescher, Kirsten, Kühn, Joachim, Lorentzen, Eva, Hafezi, Wali, Derksen, Andrea, Deters, Alexandra, Hensel, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - drug effects Adenoviridae Infections - microbiology Adenovirus Adsorption aerial parts Animals Antiviral Antiviral activity Antiviral Agents - pharmacology Antiviral Agents - therapeutic use antiviral properties Attachment Biological and medical sciences Cell culture Cell Line Cell surface Cercopithecus aethiops Cytotoxicity Envelope protein fluorescent antibody technique gD protein General pharmacology glycoprotein D glycoproteins Herpes Simplex - drug therapy Herpes Simplex - microbiology Herpes simplex virus 1 Herpes simplex virus type-1 Herpesvirus 1, Human - chemistry Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - pathogenicity hosts Human herpesvirus 1 Humans Immunofluorescence Infection Inhibitory Concentration 50 Inoculum Keratinocytes - drug effects Keratinocytes - microbiology Magnoliopsida - chemistry mechanism of action Medical sciences Myrothamnaceae Myrothamnus Myrothamnus flabellifolia Welw Organotypic skin model Penetration Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy Plant Components, Aerial Plant diseases Plant Extracts - pharmacology Plant Extracts - therapeutic use Plaques Polyphenols Proanthocyanidins - pharmacology Proanthocyanidins - therapeutic use Replication Respiratory tract respiratory tract diseases Skin - drug effects Skin - microbiology Skin diseases Tissue culture Vero Cells Viral Envelope Proteins - chemistry virion Virus Integration - drug effects viruses Western blotting
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