Brn-3a neuronal transcription factor functional expression in human prostate cancer
Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both in vitro and in vivo . Brn-3a expression, but not Brn-3c, was significantly upregulated...
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| Veröffentlicht in: | Prostate cancer and prostatic diseases 2006-03, Vol.9 (1), p.83-91 |
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| creator | Diss, J K J Faulkes, D J Walker, M M Patel, A Foster, C S Budhram-Mahadeo, V Djamgoz, M B A Latchman, D S |
| description | Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both
in vitro
and
in vivo
. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor
in vitro
(i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP. |
| doi_str_mv | 10.1038/sj.pcan.4500837 |
| format | Article |
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in vitro
and
in vivo
. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor
in vitro
(i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.</description><identifier>ISSN: 1365-7852</identifier><identifier>EISSN: 1476-5608</identifier><identifier>DOI: 10.1038/sj.pcan.4500837</identifier><identifier>PMID: 16276351</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Blotting, Western ; Brn-3 protein ; Cancer Research ; Differentiation ; Gene expression ; Humans ; Male ; NAV1.7 Voltage-Gated Sodium Channel ; original-article ; Prostate cancer ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sodium channels (voltage-gated) ; Sodium Channels - genetics ; Sodium Channels - metabolism ; Transcription Factor Brn-3A - genetics ; Transcription Factor Brn-3A - metabolism ; Transcription Factor Brn-3C - genetics ; Transcription Factor Brn-3C - metabolism ; Transcription factors ; Tumor Cells, Cultured ; Tumors ; Up-Regulation</subject><ispartof>Prostate cancer and prostatic diseases, 2006-03, Vol.9 (1), p.83-91</ispartof><rights>Springer Nature Limited 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2006</rights><rights>Nature Publishing Group 2006.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-1964d14c428b7f56de6cce24f76fa709360bfc6e679d9bc04ea42e6b5e97139f3</citedby><cites>FETCH-LOGICAL-c584t-1964d14c428b7f56de6cce24f76fa709360bfc6e679d9bc04ea42e6b5e97139f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16276351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diss, J K J</creatorcontrib><creatorcontrib>Faulkes, D J</creatorcontrib><creatorcontrib>Walker, M M</creatorcontrib><creatorcontrib>Patel, A</creatorcontrib><creatorcontrib>Foster, C S</creatorcontrib><creatorcontrib>Budhram-Mahadeo, V</creatorcontrib><creatorcontrib>Djamgoz, M B A</creatorcontrib><creatorcontrib>Latchman, D S</creatorcontrib><title>Brn-3a neuronal transcription factor functional expression in human prostate cancer</title><title>Prostate cancer and prostatic diseases</title><addtitle>Prostate Cancer Prostatic Dis</addtitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><description>Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both
in vitro
and
in vivo
. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor
in vitro
(i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blotting, Western</subject><subject>Brn-3 protein</subject><subject>Cancer Research</subject><subject>Differentiation</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Male</subject><subject>NAV1.7 Voltage-Gated Sodium Channel</subject><subject>original-article</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Sodium channels (voltage-gated)</subject><subject>Sodium Channels - genetics</subject><subject>Sodium Channels - metabolism</subject><subject>Transcription Factor Brn-3A - genetics</subject><subject>Transcription Factor Brn-3A - metabolism</subject><subject>Transcription Factor Brn-3C - genetics</subject><subject>Transcription Factor Brn-3C - metabolism</subject><subject>Transcription factors</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>1365-7852</issn><issn>1476-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kstv1DAQhy0EomXhzAkUgVRO2frt-FgqXlIlDsDZcpxxN6vECbYjwX-Po11aiijywY_5fvPyIPSc4C3BrDlP--3sbNhygXHD1AN0SriStZC4eVjOTIpaNYKeoCcp7THGmmj8GJ0QSZVkgpyiL29jqJmtAixxCnaocrQhudjPuZ9C5a3LU6z8Etx6L3b4MUdIaTX2odotow3VHKeUbYaqpOIgPkWPvB0SPDvuG_Tt_buvlx_rq88fPl1eXNVONDzXREveEe44bVrlhexAOgeUeyW9VVgziVvvJEilO906zMFyCrIVoBVh2rMNenPwW-J_XyBlM_bJwTDYANOSjMaUcUaULuTZf0mpFBONwgV8_Re4n5ZY6k6GSi4YkYrQQr26l6IaY85Kd29cXdsBTB_8VFrr1rjmgjSacqFLdhu0_QdVVgdj76YAvi_vdwRnfwh2YIe8S9OwrN-T7oLnB9CV30kRvJljP9r40xBs1uExaW_W4THH4SmKl8eylnaE7pY_TksB8AFIxRSuId7Wfb_PFwdJsHmJcOPzt_0XsH7Xyw</recordid><startdate>20060301</startdate><enddate>20060301</enddate><creator>Diss, J K J</creator><creator>Faulkes, D J</creator><creator>Walker, M M</creator><creator>Patel, A</creator><creator>Foster, C S</creator><creator>Budhram-Mahadeo, V</creator><creator>Djamgoz, M B A</creator><creator>Latchman, D S</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20060301</creationdate><title>Brn-3a neuronal transcription factor functional expression in human prostate cancer</title><author>Diss, J K J ; Faulkes, D J ; Walker, M M ; Patel, A ; Foster, C S ; Budhram-Mahadeo, V ; Djamgoz, M B A ; Latchman, D S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-1964d14c428b7f56de6cce24f76fa709360bfc6e679d9bc04ea42e6b5e97139f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blotting, Western</topic><topic>Brn-3 protein</topic><topic>Cancer Research</topic><topic>Differentiation</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Male</topic><topic>NAV1.7 Voltage-Gated Sodium Channel</topic><topic>original-article</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Sodium channels (voltage-gated)</topic><topic>Sodium Channels - genetics</topic><topic>Sodium Channels - metabolism</topic><topic>Transcription Factor Brn-3A - genetics</topic><topic>Transcription Factor Brn-3A - metabolism</topic><topic>Transcription Factor Brn-3C - genetics</topic><topic>Transcription Factor Brn-3C - metabolism</topic><topic>Transcription factors</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diss, J K J</creatorcontrib><creatorcontrib>Faulkes, D J</creatorcontrib><creatorcontrib>Walker, M M</creatorcontrib><creatorcontrib>Patel, A</creatorcontrib><creatorcontrib>Foster, C S</creatorcontrib><creatorcontrib>Budhram-Mahadeo, V</creatorcontrib><creatorcontrib>Djamgoz, M B A</creatorcontrib><creatorcontrib>Latchman, D S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Prostate cancer and prostatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diss, J K J</au><au>Faulkes, D J</au><au>Walker, M M</au><au>Patel, A</au><au>Foster, C S</au><au>Budhram-Mahadeo, V</au><au>Djamgoz, M B A</au><au>Latchman, D S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brn-3a neuronal transcription factor functional expression in human prostate cancer</atitle><jtitle>Prostate cancer and prostatic diseases</jtitle><stitle>Prostate Cancer Prostatic Dis</stitle><addtitle>Prostate Cancer Prostatic Dis</addtitle><date>2006-03-01</date><risdate>2006</risdate><volume>9</volume><issue>1</issue><spage>83</spage><epage>91</epage><pages>83-91</pages><issn>1365-7852</issn><eissn>1476-5608</eissn><abstract>Neuroendocrine differentiation has been associated with prostate cancer (CaP). Brn-3a (short isoform) and Brn-3c, transcriptional controllers of neuronal differentiation, were readily detectable in human CaP both
in vitro
and
in vivo
. Brn-3a expression, but not Brn-3c, was significantly upregulated in >50% of tumours. Furthermore, overexpression of this transcription factor
in vitro
(i) potentiated CaP cell growth and (ii) regulated the expression of a neuronal gene, the Nav1.7 sodium channel, concomitantly upregulated in human CaP, in an isoform-specific manner. It is concluded that targeting Brn-3a could be a useful strategy for controlling the expression of multiple genes that promote CaP.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16276351</pmid><doi>10.1038/sj.pcan.4500837</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical and Life Sciences Biomedicine Blotting, Western Brn-3 protein Cancer Research Differentiation Gene expression Humans Male NAV1.7 Voltage-Gated Sodium Channel original-article Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Sodium channels (voltage-gated) Sodium Channels - genetics Sodium Channels - metabolism Transcription Factor Brn-3A - genetics Transcription Factor Brn-3A - metabolism Transcription Factor Brn-3C - genetics Transcription Factor Brn-3C - metabolism Transcription factors Tumor Cells, Cultured Tumors Up-Regulation |
| title | Brn-3a neuronal transcription factor functional expression in human prostate cancer |
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