Management of head and neck paragangliomas: Review of 120 patients
Background. Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally. Methods and Results. A retrospective review of 120 patients with 146 head and neck PGL, includin...
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| Veröffentlicht in: | Head & neck 2009-03, Vol.31 (3), p.381-387 |
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| creator | Papaspyrou, Konstantinos Mann, Wolf J. Amedee, Ronald G. |
| description | Background.
Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.
Methods and Results.
A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88% of TT resections.
Conclusion.
According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically. © 2008 Wiley Periodicals, Inc. Head Neck, 2009 |
| doi_str_mv | 10.1002/hed.20967 |
| format | Article |
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Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.
Methods and Results.
A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88% of TT resections.
Conclusion.
According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically. © 2008 Wiley Periodicals, Inc. Head Neck, 2009</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.20967</identifier><identifier>PMID: 18972432</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carotid Artery, Internal ; Child ; Cranial Nerve Diseases - etiology ; Deafness - etiology ; Deafness - prevention & control ; embolization ; Embolization, Therapeutic ; F-DOPA-PET ; Female ; Head and Neck Neoplasms - complications ; Head and Neck Neoplasms - therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Neurology ; Otorhinolaryngology. Stomatology ; Outcome Assessment (Health Care) ; paraganglioma ; Paraganglioma - complications ; Paraganglioma - therapy ; Postoperative Complications ; radiotherapy ; Radiotherapy, Adjuvant ; recurrence ; Retrospective Studies ; Tumors of the nervous system. Phacomatoses ; Young Adult</subject><ispartof>Head & neck, 2009-03, Vol.31 (3), p.381-387</ispartof><rights>Copyright © 2008 Wiley Periodicals, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4897-d1bcac9822b19ca00f81917478172bf0c16e984dcdfe2da1537d094bd59859293</citedby><cites>FETCH-LOGICAL-c4897-d1bcac9822b19ca00f81917478172bf0c16e984dcdfe2da1537d094bd59859293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.20967$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.20967$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21162189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18972432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Papaspyrou, Konstantinos</creatorcontrib><creatorcontrib>Mann, Wolf J.</creatorcontrib><creatorcontrib>Amedee, Ronald G.</creatorcontrib><title>Management of head and neck paragangliomas: Review of 120 patients</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.
Methods and Results.
A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88% of TT resections.
Conclusion.
According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically. © 2008 Wiley Periodicals, Inc. Head Neck, 2009</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carotid Artery, Internal</subject><subject>Child</subject><subject>Cranial Nerve Diseases - etiology</subject><subject>Deafness - etiology</subject><subject>Deafness - prevention & control</subject><subject>embolization</subject><subject>Embolization, Therapeutic</subject><subject>F-DOPA-PET</subject><subject>Female</subject><subject>Head and Neck Neoplasms - complications</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neurology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Outcome Assessment (Health Care)</subject><subject>paraganglioma</subject><subject>Paraganglioma - complications</subject><subject>Paraganglioma - therapy</subject><subject>Postoperative Complications</subject><subject>radiotherapy</subject><subject>Radiotherapy, Adjuvant</subject><subject>recurrence</subject><subject>Retrospective Studies</subject><subject>Tumors of the nervous system. Phacomatoses</subject><subject>Young Adult</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MlOwzAQBmALgdgPvADKBRCHwHhJHHODsqosEgJxtCa2UwJZStyyvD0uLb3BySPPNzPST8gWhQMKwA6fnT1goFK5QFYpKBkDF3JxUgsec5Bihax5_wIAPBVsmazQTEkmOFslJzfY4MDVrhlFbRE9O7QRNjZqnHmNhtjhAJtBVbY1-qPo3r2X7mPiKIPQHZVhzG-QpQIr7zZn7zp5PD976F3G13cXV73j69iIcC62NDdoVMZYTpVBgCKjikohMypZXoChqVOZsMYWjlmkCZcWlMhtorJEMcXXyd5077Br38bOj3RdeuOqChvXjr1WwLhgmWJB7v4r01QlSiU8wP0pNF3rfecKPezKGrsvTUFPotUhWv0TbbDbs6XjvA6_cznLMoCdGUBvsCo6bEzp545RmrKAgzucuo-ycl9_X9SXZ6e_p-PpROlH7nM-gd2rDl2Z6KfbC93r97N73j_Rgn8DxhScAw</recordid><startdate>200903</startdate><enddate>200903</enddate><creator>Papaspyrou, Konstantinos</creator><creator>Mann, Wolf J.</creator><creator>Amedee, Ronald G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>200903</creationdate><title>Management of head and neck paragangliomas: Review of 120 patients</title><author>Papaspyrou, Konstantinos ; Mann, Wolf J. ; Amedee, Ronald G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4897-d1bcac9822b19ca00f81917478172bf0c16e984dcdfe2da1537d094bd59859293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carotid Artery, Internal</topic><topic>Child</topic><topic>Cranial Nerve Diseases - etiology</topic><topic>Deafness - etiology</topic><topic>Deafness - prevention & control</topic><topic>embolization</topic><topic>Embolization, Therapeutic</topic><topic>F-DOPA-PET</topic><topic>Female</topic><topic>Head and Neck Neoplasms - complications</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neurology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Outcome Assessment (Health Care)</topic><topic>paraganglioma</topic><topic>Paraganglioma - complications</topic><topic>Paraganglioma - therapy</topic><topic>Postoperative Complications</topic><topic>radiotherapy</topic><topic>Radiotherapy, Adjuvant</topic><topic>recurrence</topic><topic>Retrospective Studies</topic><topic>Tumors of the nervous system. Phacomatoses</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Papaspyrou, Konstantinos</creatorcontrib><creatorcontrib>Mann, Wolf J.</creatorcontrib><creatorcontrib>Amedee, Ronald G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Papaspyrou, Konstantinos</au><au>Mann, Wolf J.</au><au>Amedee, Ronald G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of head and neck paragangliomas: Review of 120 patients</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2009-03</date><risdate>2009</risdate><volume>31</volume><issue>3</issue><spage>381</spage><epage>387</epage><pages>381-387</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Head and neck paragangliomas (PGL) are rare, mostly benign tumors. About 10% to 15% of PGL are caused by mutations in the succinate dehydrogenase genes B, C, or D and may appear multifocally.
Methods and Results.
A retrospective review of 120 patients with 146 head and neck PGL, including 46 carotid body tumors (CBT), 13 vagal tumors, 55 jugulotympanic tumors (JTT), 25 tympanic tumors (TT) and 7 tumors in other locations are included. The internal carotid artery was preserved in 97.5% of CBT resections. Preservation of hearing was achieved in 92% of JTT and 88% of TT resections.
Conclusion.
According to our experience, the treatment of PGL must be individualized, taking into account the patient's age, medical condition, tumor site and size, multiple occurrences, and preexisting cranial nerve deficits. Tumor control is high whether treatment is by surgery or radiotherapy. Patients with solitary lesions whose disease is potentially resectable with acceptable morbidity are better treated surgically. © 2008 Wiley Periodicals, Inc. Head Neck, 2009</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>18972432</pmid><doi>10.1002/hed.20967</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Carotid Artery, Internal Child Cranial Nerve Diseases - etiology Deafness - etiology Deafness - prevention & control embolization Embolization, Therapeutic F-DOPA-PET Female Head and Neck Neoplasms - complications Head and Neck Neoplasms - therapy Humans Male Medical sciences Middle Aged Neoplasm Recurrence, Local Neurology Otorhinolaryngology. Stomatology Outcome Assessment (Health Care) paraganglioma Paraganglioma - complications Paraganglioma - therapy Postoperative Complications radiotherapy Radiotherapy, Adjuvant recurrence Retrospective Studies Tumors of the nervous system. Phacomatoses Young Adult |
| title | Management of head and neck paragangliomas: Review of 120 patients |
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