A genome scan in 260 inflammatory bowel disease‐affected relative pairs

We report the results of a new genome scan in 260 IBD‐affected relative pairs from 139 families that we have recruited since our previous IBD genome scans were performed. The goal of our study was to determine whether we could extend the linkage evidence in any of the more than 20 regions with nomin...

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Veröffentlicht in:	Inflammatory bowel diseases 2004-01, Vol.10 (1), p.15-22
Hauptverfasser:	Barmada, M. Michael, Brant, Steven R., Nicolae, Dan L., Achkar, Jean‐Paul, Panhuysen, Carolien I., Bayless, Theodore M., Cho, Judy H., Duerr, Richard H.
Format:	Artikel
Sprache:	eng
Schlagworte:	chromosome mapping Colitis, Ulcerative - genetics Crohn Disease - genetics Crohn's disease/genetics Genetic Linkage Genetic Predisposition to Disease Genomes Genotype human Humans Inflammatory bowel diseases inflammatory bowel diseases/genetics Intestine linkage (genetics) major histocompatibility complex Pedigree
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Beschreibung
Zusammenfassung:	We report the results of a new genome scan in 260 IBD‐affected relative pairs from 139 families that we have recruited since our previous IBD genome scans were performed. The goal of our study was to determine whether we could extend the linkage evidence in any of the more than 20 regions with nominal evidence for linkage to IBD in previous individual genome scans in order to prioritize regions for further study.
ISSN:	1078-0998 1536-4844
DOI:	10.1097/00054725-200401000-00002