Extracellular acidosis promotes neutrophil transdifferentiation to MHC class II-expressing cells

► Acidosis enhances cytokine-induced expression of MHC class II in neutrophils. ► Acidosis potentiates antigen uptake by MHC class II-expressing neutrophils. ► Acidosis potentiates antigen presentation by MHC class II-expressing neutrophils. Inflammation in peripheral tissues is usually associated w...

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Veröffentlicht in:	Cellular immunology 2011, Vol.271 (2), p.214-218
Hauptverfasser:	Pliyev, Boris K., Sumarokov, Alexander B., Buriachkovskaia, Lyudmila I., Menshikov, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis - immunology Acidosis - pathology Antigen Presentation B7-1 Antigen - metabolism B7-2 Antigen - metabolism Cell Transdifferentiation - drug effects Cell Transdifferentiation - immunology Extracellular acidosis Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Histocompatibility Antigens Class II - metabolism HLA-DR Antigens - metabolism Humans In Vitro Techniques Inflammation - immunology Inflammation - pathology Interferon-gamma - pharmacology MHC class II Neutrophil transdifferentiation Neutrophils - drug effects Neutrophils - immunology Neutrophils - pathology Phagocytosis
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