Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study
Background The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion. Methods Thirty‐eight of the carcinomas were studied. In‐situ hybridization and polymerase chain reaction were...
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| Veröffentlicht in: | Head & neck 2000-07, Vol.22 (4), p.360-368 |
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| creator | Suarez, Patricia A. Adler-Storthz, Karen Luna, Mario A. El-Naggar, Adel K. Abdul-Karim, Fadi W. Batsakis, John G. |
| description | Background
The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion.
Methods
Thirty‐eight of the carcinomas were studied. In‐situ hybridization and polymerase chain reaction were performed to detect human papilloma virus (HPV) and p53 expression.
Results
HPV was found in 4 of 14 assessable carcinomas by in‐situ hybridization and in 5 of 14 by polymerase chain reaction. The most frequently identified HPVs were HPVs in 6/11 and 16/18 patients. In general, a reciprocal relationship was found between p53 and HPV prevalence. The most lethal site for this tumor was the sinonasal tract, whereas patients with papillary squamous cell carcinomas of the larynx had the best outlook. Eleven of 25 (44%) assessable patients died of disease (mean time interval, 2 year).
Conclusions
Papillary squamous cell carcinoma of the upper aerodigestive tract is a distinct variant of squamous cell carcinoma. As such and because of its putative association with HPV, papillary squamous cell carcinoma could be an informative model for defining how viral oncogenes cooperate with other factors in genomic instability, carcinogenesis, and tumor development. © 2000 John Wiley & Sons, Inc. Head Neck 22: 360–368, 2000. |
| doi_str_mv | 10.1002/1097-0347(200007)22:4<360::AID-HED8>3.0.CO;2-W |
| format | Article |
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The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion.
Methods
Thirty‐eight of the carcinomas were studied. In‐situ hybridization and polymerase chain reaction were performed to detect human papilloma virus (HPV) and p53 expression.
Results
HPV was found in 4 of 14 assessable carcinomas by in‐situ hybridization and in 5 of 14 by polymerase chain reaction. The most frequently identified HPVs were HPVs in 6/11 and 16/18 patients. In general, a reciprocal relationship was found between p53 and HPV prevalence. The most lethal site for this tumor was the sinonasal tract, whereas patients with papillary squamous cell carcinomas of the larynx had the best outlook. Eleven of 25 (44%) assessable patients died of disease (mean time interval, 2 year).
Conclusions
Papillary squamous cell carcinoma of the upper aerodigestive tract is a distinct variant of squamous cell carcinoma. As such and because of its putative association with HPV, papillary squamous cell carcinoma could be an informative model for defining how viral oncogenes cooperate with other factors in genomic instability, carcinogenesis, and tumor development. © 2000 John Wiley & Sons, Inc. Head Neck 22: 360–368, 2000.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/1097-0347(200007)22:4<360::AID-HED8>3.0.CO;2-W</identifier><identifier>PMID: 10862019</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy, Needle ; Biotechnology ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - virology ; clinicopathologic study ; Diagnosis, Differential ; Female ; Fundamental and applied biological sciences. Psychology ; Genes, p53 - physiology ; Genetic engineering ; Genetic technics ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - virology ; Human papillomavirus ; Humans ; In Situ Hybridization ; In vitro gene amplification. Pcr technique ; Laryngeal Neoplasms - diagnosis ; Male ; Medical sciences ; Methods. Procedures. Technologies ; Middle Aged ; molecular study ; Otorhinolaryngology. Stomatology ; papillary squamous cell carcinomas ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - pathology ; Papillomavirus Infections - virology ; Polymerase Chain Reaction ; Retrospective Studies ; Sensitivity and Specificity ; Tumor Virus Infections - pathology ; Tumor Virus Infections - virology ; Tumors ; upper aerodigestive tract ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 2000-07, Vol.22 (4), p.360-368</ispartof><rights>Copyright © 2000 John Wiley & Sons, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 John Wiley & Sons, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5158-efee469e72c99ca92d5ea9d9a42eefda4307efd6d4a30db5d73afa1e295a4ec33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1097-0347%28200007%2922%3A4%3C360%3A%3AAID-HED8%3E3.0.CO%3B2-W$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1097-0347%28200007%2922%3A4%3C360%3A%3AAID-HED8%3E3.0.CO%3B2-W$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1399567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10862019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suarez, Patricia A.</creatorcontrib><creatorcontrib>Adler-Storthz, Karen</creatorcontrib><creatorcontrib>Luna, Mario A.</creatorcontrib><creatorcontrib>El-Naggar, Adel K.</creatorcontrib><creatorcontrib>Abdul-Karim, Fadi W.</creatorcontrib><creatorcontrib>Batsakis, John G.</creatorcontrib><title>Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion.
Methods
Thirty‐eight of the carcinomas were studied. In‐situ hybridization and polymerase chain reaction were performed to detect human papilloma virus (HPV) and p53 expression.
Results
HPV was found in 4 of 14 assessable carcinomas by in‐situ hybridization and in 5 of 14 by polymerase chain reaction. The most frequently identified HPVs were HPVs in 6/11 and 16/18 patients. In general, a reciprocal relationship was found between p53 and HPV prevalence. The most lethal site for this tumor was the sinonasal tract, whereas patients with papillary squamous cell carcinomas of the larynx had the best outlook. Eleven of 25 (44%) assessable patients died of disease (mean time interval, 2 year).
Conclusions
Papillary squamous cell carcinoma of the upper aerodigestive tract is a distinct variant of squamous cell carcinoma. As such and because of its putative association with HPV, papillary squamous cell carcinoma could be an informative model for defining how viral oncogenes cooperate with other factors in genomic instability, carcinogenesis, and tumor development. © 2000 John Wiley & Sons, Inc. Head Neck 22: 360–368, 2000.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Biotechnology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>clinicopathologic study</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, p53 - physiology</subject><subject>Genetic engineering</subject><subject>Genetic technics</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - virology</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>In vitro gene amplification. Pcr technique</subject><subject>Laryngeal Neoplasms - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methods. Procedures. Technologies</subject><subject>Middle Aged</subject><subject>molecular study</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>papillary squamous cell carcinomas</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - virology</subject><subject>Polymerase Chain Reaction</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumor Virus Infections - virology</subject><subject>Tumors</subject><subject>upper aerodigestive tract</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU9v1DAQxSMEon_gKyAfkKCHLI7tJOsFIS27ZVtRdTkUltto6kxaQ7JJ7QTYb49DVoUDF3wZW3r-zcx7UZQlfJJwLl4lXOcxlyp_KXg4-YkQM_VGZnw2m58v47PT5fStnPDJYv1axJsH0eH9h4fDXclY8lwdREfefw3_ZabE4-gg4dNM8EQfRtVHbG1Vodsxf9dj3fSeGaoqZtAZu21q9KwpWXdLrG9bcgzJNYW9Id_Z78Q6h6absTkzld1a07TY3TZVc2MNw23B6qYi0wc6811f7J5Ej0qsPD3d1-Po0_vTq8VZfLFenS_mF7FJk3QaU0mkMk25MFob1KJICXWhUQmiskAVVgo1KxRKXlynRS6xxISETlGRkfI4ejFyW9fc9WFUqK0ftsIthQVBcyEV1yIJystRaVzjvaMSWmfr4AYkHIYAYPATBj9hDACEAAUhAIAQAAwBgAQOizUI2ATgs33r_rqm4i_c6HgQPN8L0BusSodbY_0fndQ6zfIgW4-yH7ai3X9M9Y-hfr8DMR6J1nf0856I7huEfnkKm8sVfHh39Xn6RSxhJX8BTxG7yw</recordid><startdate>200007</startdate><enddate>200007</enddate><creator>Suarez, Patricia A.</creator><creator>Adler-Storthz, Karen</creator><creator>Luna, Mario A.</creator><creator>El-Naggar, Adel K.</creator><creator>Abdul-Karim, Fadi W.</creator><creator>Batsakis, John G.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>200007</creationdate><title>Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study</title><author>Suarez, Patricia A. ; Adler-Storthz, Karen ; Luna, Mario A. ; El-Naggar, Adel K. ; Abdul-Karim, Fadi W. ; Batsakis, John G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5158-efee469e72c99ca92d5ea9d9a42eefda4307efd6d4a30db5d73afa1e295a4ec33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Biotechnology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>clinicopathologic study</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, p53 - physiology</topic><topic>Genetic engineering</topic><topic>Genetic technics</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - virology</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>In vitro gene amplification. Pcr technique</topic><topic>Laryngeal Neoplasms - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methods. Procedures. Technologies</topic><topic>Middle Aged</topic><topic>molecular study</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>papillary squamous cell carcinomas</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - virology</topic><topic>Polymerase Chain Reaction</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumor Virus Infections - virology</topic><topic>Tumors</topic><topic>upper aerodigestive tract</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suarez, Patricia A.</creatorcontrib><creatorcontrib>Adler-Storthz, Karen</creatorcontrib><creatorcontrib>Luna, Mario A.</creatorcontrib><creatorcontrib>El-Naggar, Adel K.</creatorcontrib><creatorcontrib>Abdul-Karim, Fadi W.</creatorcontrib><creatorcontrib>Batsakis, John G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suarez, Patricia A.</au><au>Adler-Storthz, Karen</au><au>Luna, Mario A.</au><au>El-Naggar, Adel K.</au><au>Abdul-Karim, Fadi W.</au><au>Batsakis, John G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2000-07</date><risdate>2000</risdate><volume>22</volume><issue>4</issue><spage>360</spage><epage>368</epage><pages>360-368</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
The limited studies and the small number of published cases of papillary squamous cell carcinoma have precluded accurate assessment of the biologic characteristics of this lesion.
Methods
Thirty‐eight of the carcinomas were studied. In‐situ hybridization and polymerase chain reaction were performed to detect human papilloma virus (HPV) and p53 expression.
Results
HPV was found in 4 of 14 assessable carcinomas by in‐situ hybridization and in 5 of 14 by polymerase chain reaction. The most frequently identified HPVs were HPVs in 6/11 and 16/18 patients. In general, a reciprocal relationship was found between p53 and HPV prevalence. The most lethal site for this tumor was the sinonasal tract, whereas patients with papillary squamous cell carcinomas of the larynx had the best outlook. Eleven of 25 (44%) assessable patients died of disease (mean time interval, 2 year).
Conclusions
Papillary squamous cell carcinoma of the upper aerodigestive tract is a distinct variant of squamous cell carcinoma. As such and because of its putative association with HPV, papillary squamous cell carcinoma could be an informative model for defining how viral oncogenes cooperate with other factors in genomic instability, carcinogenesis, and tumor development. © 2000 John Wiley & Sons, Inc. Head Neck 22: 360–368, 2000.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10862019</pmid><doi>10.1002/1097-0347(200007)22:4<360::AID-HED8>3.0.CO;2-W</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biopsy, Needle Biotechnology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology clinicopathologic study Diagnosis, Differential Female Fundamental and applied biological sciences. Psychology Genes, p53 - physiology Genetic engineering Genetic technics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Human papillomavirus Humans In Situ Hybridization In vitro gene amplification. Pcr technique Laryngeal Neoplasms - diagnosis Male Medical sciences Methods. Procedures. Technologies Middle Aged molecular study Otorhinolaryngology. Stomatology papillary squamous cell carcinomas Papillomaviridae - isolation & purification Papillomavirus Infections - pathology Papillomavirus Infections - virology Polymerase Chain Reaction Retrospective Studies Sensitivity and Specificity Tumor Virus Infections - pathology Tumor Virus Infections - virology Tumors upper aerodigestive tract Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Papillary squamous cell carcinomas of the upper aerodigestive tract: A clinicopathologic and molecular study |
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