Identification of AGR2 protein, a novel potential cancer marker, using proteomics technologies
A comparative analysis of the proteins in prostate tissues of the patients operated for hyperplasia (n = 7) or cancer (n = 5) was performed aiming to search for protein diagnostic markers. Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'F...
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| Veröffentlicht in: | Applied biochemistry and microbiology 2006-07, Vol.42 (4), p.480-427 |
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| container_title | Applied biochemistry and microbiology |
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| creator | Kovalev, L I Shishkin, S S Khasigov, P Z Dzeranov, N K Kazachenko, A V Toropygin, I Iu Mamykina, S V |
| description | A comparative analysis of the proteins in prostate tissues of the patients operated for hyperplasia (n = 7) or cancer (n = 5) was performed aiming to search for protein diagnostic markers. Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'Farrel; among them, an additional protein with a molecular weight of 19 kDa and an isoelectric point of 9.0 was observed in four of the cancer cases. Mass spectrometry allowed this protein to be identified as the androgen-induced secreted protein AGR2. The possibility of using AGR2 as a diagnostic marker of prostate cancer is discussed. |
| doi_str_mv | 10.1134/S0003683806040156 |
| format | Article |
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Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'Farrel; among them, an additional protein with a molecular weight of 19 kDa and an isoelectric point of 9.0 was observed in four of the cancer cases. Mass spectrometry allowed this protein to be identified as the androgen-induced secreted protein AGR2. 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| subjects | Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Cancer Comparative analysis Humans Male Mass spectrometry Medical research Molecular weight Neoplasm Proteins - analysis Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism Prostate cancer Prostatic Neoplasms - chemistry Prostatic Neoplasms - diagnosis Prostatic Neoplasms - metabolism Proteins Proteins - analysis Proteins - metabolism Proteomics - methods |
| title | Identification of AGR2 protein, a novel potential cancer marker, using proteomics technologies |
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