Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli

Esterase EstB from Burkholderia gladioli belongs to a novel class of esterases homologous to penicillin binding proteins, notably DD-peptidase and class C β-lactamases. It can cleave the side chain acetyl ester group from cephalosporins leaving the β-lactam ring intact, which is a feature of relevan...

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Veröffentlicht in:	The journal of physical chemistry. B 2011-11, Vol.115 (44), p.13019-13025
Hauptverfasser:	Chen, Liang, Kong, Xiangqian, Liang, Zhongjie, Ye, Fei, Yu, Kunqian, Dai, Weiyi, Wu, Daocheng, Luo, Cheng, Jiang, Hualiang
Format:	Artikel
Sprache:	eng
Schlagworte:	B: Biophysical Chemistry Burkholderia Burkholderia gladioli Burkholderia gladioli - chemistry Burkholderia gladioli - enzymology Catalysis Catalytic Domain Cephalosporin Computer simulation Crystallography, X-Ray Enzymes Esterases Esterases - chemistry Esterases - metabolism Homology Mathematical analysis Molecular Dynamics Simulation Protons Quantum Theory Thermodynamics
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