Triazine-Based Vanilloid 1 Receptor Open Channel Blockers: Design, Synthesis, Evaluation, and SAR Analysis

The thermosensory transient receptor potential vanilloid 1 channel (TRPV1) is a polymodal receptor activated by physical and chemical stimuli. TRPV1 activity is drastically potentiated by proinflammatory agents released upon tissue damage. Given the pivotal role of TRPV1 in human pain, there is pres...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-11, Vol.54 (21), p.7441-7452
Hauptverfasser:	Vidal-Mosquera, Miquel, Fernández-Carvajal, Asia, Moure, Alejandra, Valente, Pierluigi, Planells-Cases, Rosa, González-Ros, José M, Bujons, Jordi, Ferrer-Montiel, Antonio, Messeguer, Angel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemical synthesis Analgesics - chemistry Analgesics - pharmacology Animals Binding Sites Drug Design Female Oocytes - drug effects Oocytes - physiology Patch-Clamp Techniques Rats Recombinant Proteins - antagonists & inhibitors Structure-Activity Relationship Triazines - chemical synthesis Triazines - chemistry Triazines - pharmacology TRPV Cation Channels - antagonists & inhibitors Xenopus
Online-Zugang:	Volltext
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