Overexpression of P53 in head and neck cancer

The putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene‐complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of...

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Veröffentlicht in:	Head & neck 1992-11, Vol.14 (6), p.437-444
Hauptverfasser:	Watling, David L., Gown, Allen M., Coltrera, Marc D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Benign Biological and medical sciences Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell proliferation Gene Expression Regulation, Neoplastic Genes, p53 - genetics Head Head and neck cancer Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Humans Immunocytochemistry Malignancy Medical sciences Mutation Neck Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology p53 protein Prognosis Prospective Studies squamous cell carcinoma Tumor suppressor genes Tumors
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