Mitotane (o,p'-DDD) treatment of 200 dogs with pituitary-dependent hyperadrenocorticism

Two hundred dogs with pituitary dependent hyperadrenocorticism (PDH) were treated with mitotane at an initial daily dosage of 21 to 69 mg/kg (mean = 45.2 mg/kg) for S to 14 days. During the induction period, 194 of the dogs also were given daily maintenance dosages of a glucocorticoid. Fifty of the...

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Veröffentlicht in:	Journal of veterinary internal medicine 1991-05, Vol.5 (3), p.182-190
Hauptverfasser:	Kintzer, P.P. (Tufts University, North Grafton, MA.), Peterson, M.E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocortical Hyperfunction - drug therapy Adrenocortical Hyperfunction - veterinary Adrenocorticotropic Hormone ADVERSE EFFECTS AGENTES ANTINEOPLASTICOS Animals ANTINEOPLASTIC AGENTS CHIEN CORTICOTROPIN CORTICOTROPINA CORTICOTROPINE Cortisone - analogs & derivatives Cortisone - therapeutic use Dog Diseases - drug therapy DOGS DOSAGE Dose-Response Relationship, Drug DRUG THERAPY Drug Therapy, Combination EFECTOS SECUNDARIOS EFFET SECONDAIRE ENDOCRINE DISEASES ENFERMEDADES GLANDULAS ENDOCRINAS GLANDULA PITUITARIA GLUCOCORTICOIDE GLUCOCORTICOIDES GLUCOCORTICOIDS Hydrocortisone - blood HYPOPHYSE MEDICAMENT CYTOSTATIQUE MINERALOCORTICOIDE MINERALOCORTICOIDES MINERALOCORTICOIDS Mitotane - administration & dosage Mitotane - adverse effects Mitotane - therapeutic use NEOPLASMAS NEOPLASME NEOPLASMS PERRO PITUITARY GLAND Prednisone - therapeutic use Recurrence SIDE EFFECTS SUPERVIVENCIA SURVIE SURVIVAL TERAPEUTICA MEDICAMENTOSA THERAPEUTIQUE MEDICAMENTEUSE TROUBLE ENDOCRINIEN
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