Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations
Background. Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer. Methods. Th...
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| Veröffentlicht in: | Head & neck 2003-04, Vol.25 (4), p.280-288 |
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| creator | Liu, Ming Lawson, Georges Delos, Monique Jamart, Jacques Ide, Christophe Coche, Emmanuel Weynand, Birgit Desuter, Gauthier Hamoir, Marc Remacle, Marc Marbaix, Etienne |
| description | Background.
Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer.
Methods.
The fractions of cancer cells immunostained for proliferating cell nuclear antigen (PCNA) and Ki67 were determined in 80 preoperative biopsy specimens of head and neck carcinomas. The value of both indexes to detect metastasis in the subsequent neck dissection was compared with that of the clinical and radiologic examinations.
Results.
PCNA and Ki67 indexes correlated with neck metastasis. Cutoff points were determined for both indexes to discriminate metastatic from nonmetastatic carcinomas. By multivariate logistic regression, these indexes were significant predictors of metastases, together with clinical T stage and neck palpation.
Conclusion.
The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 280–288, 2003 |
| doi_str_mv | 10.1002/hed.10218 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902333474</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73129914</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3368-18812bdb5e40510c283392d41e8db30cb485d7d5a03610ecbcec04bf42aa0a5d3</originalsourceid><addsrcrecordid>eNp9kk1vEzEQhlcIREvhwB9AvgDisNQf-5XeUCgNEAGHoh4trz2bDPXawd5tmx_Nf8CbhHICyZLt0TPv2DNvlj1n9C2jlJ-uwaQDZ82D7JjRWZ1TUdQPp3MhckHr4ih7EuMPSqmoCv44O2K8Kpta8OPs17cABvWAN0BulB2B-I4MayBdUCnq3XTXymkIRIO1kWDfj85b1YIFQzofyCZ4ix0ENaBb7SjiRm1BBaLcgCtIIoF8xqom6EiLfhMR4iS8BmUSY4gDfZ3KBI3O9yqSwRM0kJK7LbHbfrMmzhsgPQwqpoXxjMx9v1EBY3riLQ5roi061Mru9IIy6K1foSZwp3p0avpLfJo96pSN8Oywn2TfP5xfzhf58uvFx_m7Za6FqJqcNQ3jrWlLKGjJqOaNEDNuCgaNaQXVbdGUpjalSv1kFHSrQdOi7QquFFWlESfZ671uas3PEeIge4xTY5QDP0Y5o1yINKMika_-S9aC8dmMTeCbPaiDjzFAJzcBexW2klE5uUAmF8idCxL74iA6tn2K3pOHsSfg5QFQMbUszdppjH-5oko-EZPQ6Z67RQvbf1eUi_P3f0rn-wyMA9zdZ6hwLata1KW8-nIhL3l51Sw-zeRS_AaylN1O</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73129914</pqid></control><display><type>article</type><title>Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Liu, Ming ; Lawson, Georges ; Delos, Monique ; Jamart, Jacques ; Ide, Christophe ; Coche, Emmanuel ; Weynand, Birgit ; Desuter, Gauthier ; Hamoir, Marc ; Remacle, Marc ; Marbaix, Etienne</creator><creatorcontrib>Liu, Ming ; Lawson, Georges ; Delos, Monique ; Jamart, Jacques ; Ide, Christophe ; Coche, Emmanuel ; Weynand, Birgit ; Desuter, Gauthier ; Hamoir, Marc ; Remacle, Marc ; Marbaix, Etienne</creatorcontrib><description>Background.
Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer.
Methods.
The fractions of cancer cells immunostained for proliferating cell nuclear antigen (PCNA) and Ki67 were determined in 80 preoperative biopsy specimens of head and neck carcinomas. The value of both indexes to detect metastasis in the subsequent neck dissection was compared with that of the clinical and radiologic examinations.
Results.
PCNA and Ki67 indexes correlated with neck metastasis. Cutoff points were determined for both indexes to discriminate metastatic from nonmetastatic carcinomas. By multivariate logistic regression, these indexes were significant predictors of metastases, together with clinical T stage and neck palpation.
Conclusion.
The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 280–288, 2003</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.10218</identifier><identifier>PMID: 12658732</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biopsy ; Carcinoma ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - secondary ; Cell Fractionation ; Female ; Head ; head and neck ; Head and neck cancer ; Host-tumor relations. Immunology. Biological markers ; Humans ; Immunohistochemistry ; Ki-67 Antigen - immunology ; Ki67 ; Laryngeal Neoplasms - diagnosis ; Laryngeal Neoplasms - immunology ; Laryngeal Neoplasms - pathology ; Lymph nodes ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic Metastasis - immunology ; Lymphatic Metastasis - pathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Metastases ; metastasis ; Middle Aged ; Mouth Neoplasms - diagnosis ; Mouth Neoplasms - immunology ; Mouth Neoplasms - pathology ; Neck ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; PCNA ; Pharyngeal Neoplasms - diagnosis ; Pharyngeal Neoplasms - immunology ; Pharyngeal Neoplasms - pathology ; Predictive Value of Tests ; Proliferating cell nuclear antigen ; Proliferating Cell Nuclear Antigen - immunology ; Reproducibility of Results ; Sensitivity and Specificity ; Tomography, Spiral Computed ; Tumors</subject><ispartof>Head & neck, 2003-04, Vol.25 (4), p.280-288</ispartof><rights>Copyright © 2003 Wiley Periodicals, Inc.</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3368-18812bdb5e40510c283392d41e8db30cb485d7d5a03610ecbcec04bf42aa0a5d3</citedby><cites>FETCH-LOGICAL-c3368-18812bdb5e40510c283392d41e8db30cb485d7d5a03610ecbcec04bf42aa0a5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.10218$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.10218$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14664238$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12658732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ming</creatorcontrib><creatorcontrib>Lawson, Georges</creatorcontrib><creatorcontrib>Delos, Monique</creatorcontrib><creatorcontrib>Jamart, Jacques</creatorcontrib><creatorcontrib>Ide, Christophe</creatorcontrib><creatorcontrib>Coche, Emmanuel</creatorcontrib><creatorcontrib>Weynand, Birgit</creatorcontrib><creatorcontrib>Desuter, Gauthier</creatorcontrib><creatorcontrib>Hamoir, Marc</creatorcontrib><creatorcontrib>Remacle, Marc</creatorcontrib><creatorcontrib>Marbaix, Etienne</creatorcontrib><title>Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer.
Methods.
The fractions of cancer cells immunostained for proliferating cell nuclear antigen (PCNA) and Ki67 were determined in 80 preoperative biopsy specimens of head and neck carcinomas. The value of both indexes to detect metastasis in the subsequent neck dissection was compared with that of the clinical and radiologic examinations.
Results.
PCNA and Ki67 indexes correlated with neck metastasis. Cutoff points were determined for both indexes to discriminate metastatic from nonmetastatic carcinomas. By multivariate logistic regression, these indexes were significant predictors of metastases, together with clinical T stage and neck palpation.
Conclusion.
The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 280–288, 2003</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinoma</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Cell Fractionation</subject><subject>Female</subject><subject>Head</subject><subject>head and neck</subject><subject>Head and neck cancer</subject><subject>Host-tumor relations. Immunology. Biological markers</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - immunology</subject><subject>Ki67</subject><subject>Laryngeal Neoplasms - diagnosis</subject><subject>Laryngeal Neoplasms - immunology</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic Metastasis - immunology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>metastasis</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - diagnosis</subject><subject>Mouth Neoplasms - immunology</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neck</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>PCNA</subject><subject>Pharyngeal Neoplasms - diagnosis</subject><subject>Pharyngeal Neoplasms - immunology</subject><subject>Pharyngeal Neoplasms - pathology</subject><subject>Predictive Value of Tests</subject><subject>Proliferating cell nuclear antigen</subject><subject>Proliferating Cell Nuclear Antigen - immunology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Tomography, Spiral Computed</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk1vEzEQhlcIREvhwB9AvgDisNQf-5XeUCgNEAGHoh4trz2bDPXawd5tmx_Nf8CbhHICyZLt0TPv2DNvlj1n9C2jlJ-uwaQDZ82D7JjRWZ1TUdQPp3MhckHr4ih7EuMPSqmoCv44O2K8Kpta8OPs17cABvWAN0BulB2B-I4MayBdUCnq3XTXymkIRIO1kWDfj85b1YIFQzofyCZ4ix0ENaBb7SjiRm1BBaLcgCtIIoF8xqom6EiLfhMR4iS8BmUSY4gDfZ3KBI3O9yqSwRM0kJK7LbHbfrMmzhsgPQwqpoXxjMx9v1EBY3riLQ5roi061Mru9IIy6K1foSZwp3p0avpLfJo96pSN8Oywn2TfP5xfzhf58uvFx_m7Za6FqJqcNQ3jrWlLKGjJqOaNEDNuCgaNaQXVbdGUpjalSv1kFHSrQdOi7QquFFWlESfZ671uas3PEeIge4xTY5QDP0Y5o1yINKMika_-S9aC8dmMTeCbPaiDjzFAJzcBexW2klE5uUAmF8idCxL74iA6tn2K3pOHsSfg5QFQMbUszdppjH-5oko-EZPQ6Z67RQvbf1eUi_P3f0rn-wyMA9zdZ6hwLata1KW8-nIhL3l51Sw-zeRS_AaylN1O</recordid><startdate>200304</startdate><enddate>200304</enddate><creator>Liu, Ming</creator><creator>Lawson, Georges</creator><creator>Delos, Monique</creator><creator>Jamart, Jacques</creator><creator>Ide, Christophe</creator><creator>Coche, Emmanuel</creator><creator>Weynand, Birgit</creator><creator>Desuter, Gauthier</creator><creator>Hamoir, Marc</creator><creator>Remacle, Marc</creator><creator>Marbaix, Etienne</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200304</creationdate><title>Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations</title><author>Liu, Ming ; Lawson, Georges ; Delos, Monique ; Jamart, Jacques ; Ide, Christophe ; Coche, Emmanuel ; Weynand, Birgit ; Desuter, Gauthier ; Hamoir, Marc ; Remacle, Marc ; Marbaix, Etienne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3368-18812bdb5e40510c283392d41e8db30cb485d7d5a03610ecbcec04bf42aa0a5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Carcinoma</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Cell Fractionation</topic><topic>Female</topic><topic>Head</topic><topic>head and neck</topic><topic>Head and neck cancer</topic><topic>Host-tumor relations. Immunology. Biological markers</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ki-67 Antigen - immunology</topic><topic>Ki67</topic><topic>Laryngeal Neoplasms - diagnosis</topic><topic>Laryngeal Neoplasms - immunology</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic Metastasis - immunology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>metastasis</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - diagnosis</topic><topic>Mouth Neoplasms - immunology</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neck</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>PCNA</topic><topic>Pharyngeal Neoplasms - diagnosis</topic><topic>Pharyngeal Neoplasms - immunology</topic><topic>Pharyngeal Neoplasms - pathology</topic><topic>Predictive Value of Tests</topic><topic>Proliferating cell nuclear antigen</topic><topic>Proliferating Cell Nuclear Antigen - immunology</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Tomography, Spiral Computed</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ming</creatorcontrib><creatorcontrib>Lawson, Georges</creatorcontrib><creatorcontrib>Delos, Monique</creatorcontrib><creatorcontrib>Jamart, Jacques</creatorcontrib><creatorcontrib>Ide, Christophe</creatorcontrib><creatorcontrib>Coche, Emmanuel</creatorcontrib><creatorcontrib>Weynand, Birgit</creatorcontrib><creatorcontrib>Desuter, Gauthier</creatorcontrib><creatorcontrib>Hamoir, Marc</creatorcontrib><creatorcontrib>Remacle, Marc</creatorcontrib><creatorcontrib>Marbaix, Etienne</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ming</au><au>Lawson, Georges</au><au>Delos, Monique</au><au>Jamart, Jacques</au><au>Ide, Christophe</au><au>Coche, Emmanuel</au><au>Weynand, Birgit</au><au>Desuter, Gauthier</au><au>Hamoir, Marc</au><au>Remacle, Marc</au><au>Marbaix, Etienne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2003-04</date><risdate>2003</risdate><volume>25</volume><issue>4</issue><spage>280</spage><epage>288</epage><pages>280-288</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Neck metastasis is a major prognostic factor of head and neck carcinoma, but its preoperative detection is currently unreliable. Molecular markers of the metastatic potential of a carcinoma would help to avoid unnecessary neck dissection in patients with nonmetastatic cancer.
Methods.
The fractions of cancer cells immunostained for proliferating cell nuclear antigen (PCNA) and Ki67 were determined in 80 preoperative biopsy specimens of head and neck carcinomas. The value of both indexes to detect metastasis in the subsequent neck dissection was compared with that of the clinical and radiologic examinations.
Results.
PCNA and Ki67 indexes correlated with neck metastasis. Cutoff points were determined for both indexes to discriminate metastatic from nonmetastatic carcinomas. By multivariate logistic regression, these indexes were significant predictors of metastases, together with clinical T stage and neck palpation.
Conclusion.
The fraction of cancer cells immunolabeled for PCNA or Ki67 in preoperative biopsy specimens is helpful to predict neck metastasis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 280–288, 2003</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12658732</pmid><doi>10.1002/hed.10218</doi><tpages>9</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biopsy Carcinoma Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - secondary Cell Fractionation Female Head head and neck Head and neck cancer Host-tumor relations. Immunology. Biological markers Humans Immunohistochemistry Ki-67 Antigen - immunology Ki67 Laryngeal Neoplasms - diagnosis Laryngeal Neoplasms - immunology Laryngeal Neoplasms - pathology Lymph nodes Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - immunology Lymphatic Metastasis - pathology Magnetic Resonance Imaging Male Medical sciences Metastases metastasis Middle Aged Mouth Neoplasms - diagnosis Mouth Neoplasms - immunology Mouth Neoplasms - pathology Neck Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology PCNA Pharyngeal Neoplasms - diagnosis Pharyngeal Neoplasms - immunology Pharyngeal Neoplasms - pathology Predictive Value of Tests Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - immunology Reproducibility of Results Sensitivity and Specificity Tomography, Spiral Computed Tumors |
| title | Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki67 in biopsies of head and neck carcinomas to identify lymph node metastasis: Comparison with clinical and radiologic examinations |
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