Galectin-3 expression in papillary thyroid carcinoma: Relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size
Background. Galectin‐3 has been recently recognized as a promising presurgical marker of thyroid malignancy. Methods. Galectin‐3 expression was examined immunohistochemically in 202 specimens of papillary thyroid carcinoma (PTC) in relation to histomorphologic subtypes and clinicopathologic data. Re...
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| Veröffentlicht in: | Head & neck 2005-12, Vol.27 (12), p.1049-1055 |
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| creator | Cvejic, Dubravka S. Savin, Svetlana B. Petrovic, Ivana M. Paunovic, Ivan R. Tatic, Svetislav B. Havelka, Marija J. |
| description | Background.
Galectin‐3 has been recently recognized as a promising presurgical marker of thyroid malignancy.
Methods.
Galectin‐3 expression was examined immunohistochemically in 202 specimens of papillary thyroid carcinoma (PTC) in relation to histomorphologic subtypes and clinicopathologic data.
Results.
The sensitivity of galectin‐3 immunostaining versus conventional histology was 98% (100 of 102) for classical PTC, 85.2% (46 of 54) for follicular variant, and 50% (23 of 46) for follicular/solid variant of PTC. All cases (n = 36) involving lymph node metastases and 42 of 45 cases with extrathyroid invasion expressed galectin‐3. However, among the galectin‐3–positive cases (n = 169), 133 were without lymph node metastases, and 127 were without extrathyroid invasion. Galectin‐3 expression was not related to the size of intrathyroid PTC.
Conclusions.
Galectin‐3 immunohistochemical expression itself is not an indicator of local metastatic spread or extrathyroid invasion of PTC, thus being irrelevant clinically from this aspect. Galectin‐3 is an excellent marker for classical PTC but must be used with caution in diagnosing unconventional variants of PTC because of the possibility of false‐negative results. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005 |
| doi_str_mv | 10.1002/hed.20276 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902333434</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902333434</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4236-3abfabb51f9b1ebe3a6c77fe825d46666aba9baf498f0af8db1a3f1210ea51763</originalsourceid><addsrcrecordid>eNp9kc1u1DAUhS0EomVgwQsgbwAhTVo7TuKEXTWUKVJVJMSfurFuHLsxJHZqe2inL9NXxcNMywpsS9eyvnuOdQ9Czyk5oITkh73qDnKS8-oB2qek4RlhBX-4uRcsY4QXe-hJCD8IIawq8sdoj1a0LBta76PbJQxKRmMzhtX15FUIxllsLJ5gMsMAfo1jv_bOdFiCl8a6Ed7iT2qAuAGjw70J0Y3OT70b3IWR-MK7q9gngRiVt3M8rMepx9Z1Co8qQkjHhHmyix7utI39BRvnOQbb4bhKejiYG_UUPdIwBPVsV2foy_vjz4uT7PTj8sPi6DSTRc6qjEGroW1LqpuWqlYxqCTnWtV52RVVWtBC04IumloT0HXXUmCa5pQoKCmv2Ay93upO3l2uVIhiNEGqNACr3CqIhuSMsSLtGXr1X7Kqa5rz9KsZerMFpXcheKXF5M2YBiooEZvcRMpN_MktsS92oqt2TK_35C6oBLzcARAkDNqDlSb85TijZVPzxB1uuSszqPW_HcXJ8bs762zbkWJU1_cd4H-KijNeim9nS3HefP1enS3PxYL9Bkfxwrw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68812742</pqid></control><display><type>article</type><title>Galectin-3 expression in papillary thyroid carcinoma: Relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Cvejic, Dubravka S. ; Savin, Svetlana B. ; Petrovic, Ivana M. ; Paunovic, Ivan R. ; Tatic, Svetislav B. ; Havelka, Marija J.</creator><creatorcontrib>Cvejic, Dubravka S. ; Savin, Svetlana B. ; Petrovic, Ivana M. ; Paunovic, Ivan R. ; Tatic, Svetislav B. ; Havelka, Marija J.</creatorcontrib><description>Background.
Galectin‐3 has been recently recognized as a promising presurgical marker of thyroid malignancy.
Methods.
Galectin‐3 expression was examined immunohistochemically in 202 specimens of papillary thyroid carcinoma (PTC) in relation to histomorphologic subtypes and clinicopathologic data.
Results.
The sensitivity of galectin‐3 immunostaining versus conventional histology was 98% (100 of 102) for classical PTC, 85.2% (46 of 54) for follicular variant, and 50% (23 of 46) for follicular/solid variant of PTC. All cases (n = 36) involving lymph node metastases and 42 of 45 cases with extrathyroid invasion expressed galectin‐3. However, among the galectin‐3–positive cases (n = 169), 133 were without lymph node metastases, and 127 were without extrathyroid invasion. Galectin‐3 expression was not related to the size of intrathyroid PTC.
Conclusions.
Galectin‐3 immunohistochemical expression itself is not an indicator of local metastatic spread or extrathyroid invasion of PTC, thus being irrelevant clinically from this aspect. Galectin‐3 is an excellent marker for classical PTC but must be used with caution in diagnosing unconventional variants of PTC because of the possibility of false‐negative results. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.20276</identifier><identifier>PMID: 16155918</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Carcinoma, Papillary - metabolism ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary, Follicular - metabolism ; Carcinoma, Papillary, Follicular - pathology ; Child ; Data processing ; Endocrinopathies ; Female ; Galectin 3 - metabolism ; galectin-3 ; Growth patterns ; Head ; Humans ; Immunohistochemistry ; Lymph nodes ; Lymphatic Metastasis ; Male ; Malignancy ; Medical sciences ; Metastases ; Middle Aged ; Neck ; Neoplasm Invasiveness ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Otorhinolaryngology. Stomatology ; papillary carcinoma ; papillary thyroid carcinoma ; thyroid ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Thyroid. Thyroid axis (diseases) ; tumor marker ; Tumors</subject><ispartof>Head & neck, 2005-12, Vol.27 (12), p.1049-1055</ispartof><rights>Copyright © 2005 Wiley Periodicals, Inc.</rights><rights>2006 INIST-CNRS</rights><rights>(c) 2005 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4236-3abfabb51f9b1ebe3a6c77fe825d46666aba9baf498f0af8db1a3f1210ea51763</citedby><cites>FETCH-LOGICAL-c4236-3abfabb51f9b1ebe3a6c77fe825d46666aba9baf498f0af8db1a3f1210ea51763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.20276$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.20276$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17315987$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16155918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cvejic, Dubravka S.</creatorcontrib><creatorcontrib>Savin, Svetlana B.</creatorcontrib><creatorcontrib>Petrovic, Ivana M.</creatorcontrib><creatorcontrib>Paunovic, Ivan R.</creatorcontrib><creatorcontrib>Tatic, Svetislav B.</creatorcontrib><creatorcontrib>Havelka, Marija J.</creatorcontrib><title>Galectin-3 expression in papillary thyroid carcinoma: Relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Galectin‐3 has been recently recognized as a promising presurgical marker of thyroid malignancy.
Methods.
Galectin‐3 expression was examined immunohistochemically in 202 specimens of papillary thyroid carcinoma (PTC) in relation to histomorphologic subtypes and clinicopathologic data.
Results.
The sensitivity of galectin‐3 immunostaining versus conventional histology was 98% (100 of 102) for classical PTC, 85.2% (46 of 54) for follicular variant, and 50% (23 of 46) for follicular/solid variant of PTC. All cases (n = 36) involving lymph node metastases and 42 of 45 cases with extrathyroid invasion expressed galectin‐3. However, among the galectin‐3–positive cases (n = 169), 133 were without lymph node metastases, and 127 were without extrathyroid invasion. Galectin‐3 expression was not related to the size of intrathyroid PTC.
Conclusions.
Galectin‐3 immunohistochemical expression itself is not an indicator of local metastatic spread or extrathyroid invasion of PTC, thus being irrelevant clinically from this aspect. Galectin‐3 is an excellent marker for classical PTC but must be used with caution in diagnosing unconventional variants of PTC because of the possibility of false‐negative results. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Papillary, Follicular - metabolism</subject><subject>Carcinoma, Papillary, Follicular - pathology</subject><subject>Child</subject><subject>Data processing</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Galectin 3 - metabolism</subject><subject>galectin-3</subject><subject>Growth patterns</subject><subject>Head</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Malignancy</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>Middle Aged</subject><subject>Neck</subject><subject>Neoplasm Invasiveness</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>papillary carcinoma</subject><subject>papillary thyroid carcinoma</subject><subject>thyroid</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>tumor marker</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EomVgwQsgbwAhTVo7TuKEXTWUKVJVJMSfurFuHLsxJHZqe2inL9NXxcNMywpsS9eyvnuOdQ9Czyk5oITkh73qDnKS8-oB2qek4RlhBX-4uRcsY4QXe-hJCD8IIawq8sdoj1a0LBta76PbJQxKRmMzhtX15FUIxllsLJ5gMsMAfo1jv_bOdFiCl8a6Ed7iT2qAuAGjw70J0Y3OT70b3IWR-MK7q9gngRiVt3M8rMepx9Z1Co8qQkjHhHmyix7utI39BRvnOQbb4bhKejiYG_UUPdIwBPVsV2foy_vjz4uT7PTj8sPi6DSTRc6qjEGroW1LqpuWqlYxqCTnWtV52RVVWtBC04IumloT0HXXUmCa5pQoKCmv2Ay93upO3l2uVIhiNEGqNACr3CqIhuSMsSLtGXr1X7Kqa5rz9KsZerMFpXcheKXF5M2YBiooEZvcRMpN_MktsS92oqt2TK_35C6oBLzcARAkDNqDlSb85TijZVPzxB1uuSszqPW_HcXJ8bs762zbkWJU1_cd4H-KijNeim9nS3HefP1enS3PxYL9Bkfxwrw</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Cvejic, Dubravka S.</creator><creator>Savin, Svetlana B.</creator><creator>Petrovic, Ivana M.</creator><creator>Paunovic, Ivan R.</creator><creator>Tatic, Svetislav B.</creator><creator>Havelka, Marija J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>200512</creationdate><title>Galectin-3 expression in papillary thyroid carcinoma: Relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size</title><author>Cvejic, Dubravka S. ; Savin, Svetlana B. ; Petrovic, Ivana M. ; Paunovic, Ivan R. ; Tatic, Svetislav B. ; Havelka, Marija J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4236-3abfabb51f9b1ebe3a6c77fe825d46666aba9baf498f0af8db1a3f1210ea51763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Papillary, Follicular - metabolism</topic><topic>Carcinoma, Papillary, Follicular - pathology</topic><topic>Child</topic><topic>Data processing</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Galectin 3 - metabolism</topic><topic>galectin-3</topic><topic>Growth patterns</topic><topic>Head</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Malignancy</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>Middle Aged</topic><topic>Neck</topic><topic>Neoplasm Invasiveness</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>papillary carcinoma</topic><topic>papillary thyroid carcinoma</topic><topic>thyroid</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>tumor marker</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cvejic, Dubravka S.</creatorcontrib><creatorcontrib>Savin, Svetlana B.</creatorcontrib><creatorcontrib>Petrovic, Ivana M.</creatorcontrib><creatorcontrib>Paunovic, Ivan R.</creatorcontrib><creatorcontrib>Tatic, Svetislav B.</creatorcontrib><creatorcontrib>Havelka, Marija J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cvejic, Dubravka S.</au><au>Savin, Svetlana B.</au><au>Petrovic, Ivana M.</au><au>Paunovic, Ivan R.</au><au>Tatic, Svetislav B.</au><au>Havelka, Marija J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galectin-3 expression in papillary thyroid carcinoma: Relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2005-12</date><risdate>2005</risdate><volume>27</volume><issue>12</issue><spage>1049</spage><epage>1055</epage><pages>1049-1055</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Galectin‐3 has been recently recognized as a promising presurgical marker of thyroid malignancy.
Methods.
Galectin‐3 expression was examined immunohistochemically in 202 specimens of papillary thyroid carcinoma (PTC) in relation to histomorphologic subtypes and clinicopathologic data.
Results.
The sensitivity of galectin‐3 immunostaining versus conventional histology was 98% (100 of 102) for classical PTC, 85.2% (46 of 54) for follicular variant, and 50% (23 of 46) for follicular/solid variant of PTC. All cases (n = 36) involving lymph node metastases and 42 of 45 cases with extrathyroid invasion expressed galectin‐3. However, among the galectin‐3–positive cases (n = 169), 133 were without lymph node metastases, and 127 were without extrathyroid invasion. Galectin‐3 expression was not related to the size of intrathyroid PTC.
Conclusions.
Galectin‐3 immunohistochemical expression itself is not an indicator of local metastatic spread or extrathyroid invasion of PTC, thus being irrelevant clinically from this aspect. Galectin‐3 is an excellent marker for classical PTC but must be used with caution in diagnosing unconventional variants of PTC because of the possibility of false‐negative results. © 2005 Wiley Periodicals, Inc. Head Neck 27: XXX–XXX, 2005</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16155918</pmid><doi>10.1002/hed.20276</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Biomarkers, Tumor - metabolism Carcinoma, Papillary - metabolism Carcinoma, Papillary - pathology Carcinoma, Papillary, Follicular - metabolism Carcinoma, Papillary, Follicular - pathology Child Data processing Endocrinopathies Female Galectin 3 - metabolism galectin-3 Growth patterns Head Humans Immunohistochemistry Lymph nodes Lymphatic Metastasis Male Malignancy Medical sciences Metastases Middle Aged Neck Neoplasm Invasiveness Non tumoral diseases. Target tissue resistance. Benign neoplasms Otorhinolaryngology. Stomatology papillary carcinoma papillary thyroid carcinoma thyroid Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Thyroid. Thyroid axis (diseases) tumor marker Tumors |
| title | Galectin-3 expression in papillary thyroid carcinoma: Relation to histomorphologic growth pattern, lymph node metastasis, extrathyroid invasion, and tumor size |
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