Differential expression of c-jun and c-fos mRNAs in squamous cell carcinoma of the head and neck: Associations with uPA, gelatinase B, and matrilysin mRNAs

Background Head and neck squamous cell carcinomas (HNSCC) are known for their invasive behavior. The invasiveness of these tumors requires proteases, some of which as urokinase‐type plasminogen activator (uPA), gelatinase B and matrilysin are regulated through AP‐1 dependent transcriptional mechanis...

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Veröffentlicht in:	Head & neck 2002-01, Vol.24 (1), p.24-32
Hauptverfasser:	Pacheco, Mercia Medeiros, Kowalski, Luis Paulo, Nishimoto, Ines Nobuko, Brentani, Maria Mitzi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - analysis Biopsy, Needle Blotting, Northern c-fos c-jun Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - pathology Culture Techniques Female Gene Expression Regulation, Neoplastic Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - pathology Humans Matrix Metalloproteinase 7 - genetics Matrix Metalloproteinase 9 - genetics Medical sciences metalloproteinases Middle Aged Neoplasm Invasiveness Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-jun - genetics RNA, Messenger - analysis RNA, Neoplasm - analysis Sensitivity and Specificity squamous cell carcinoma Statistics, Nonparametric Tumors uPA Urokinase-Type Plasminogen Activator - genetics
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