Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas
Background The prognostic significance of the invasive tumor front in squamous cell carcinomas has recently been recognized. The aim of the present study was to investigate possible molecular mechanisms underlying the significance of this area in oral squamous cell carcinomas. Methods We used immuno...
Gespeichert in:
| Veröffentlicht in: | Head & neck 1998-01, Vol.20 (1), p.8-15 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 15 |
|---|---|
| container_issue | 1 |
| container_start_page | 8 |
| container_title | Head & neck |
| container_volume | 20 |
| creator | Piffkò, Jòzsef Bànkfalvi, Àgnes Tory, Kàlmàn Füzesi, Làszlò Bryne, Magne Öfner, Dietmar Kusch, Fabian Joos, Ulrich Schmid, Kurt W. |
| description | Background
The prognostic significance of the invasive tumor front in squamous cell carcinomas has recently been recognized. The aim of the present study was to investigate possible molecular mechanisms underlying the significance of this area in oral squamous cell carcinomas.
Methods
We used immunohistochemical and molecular genetic techniques to investigate whether p53 alterations at the invasive tumor front could determine the aggressiveness of oral cancers.
Results
p53 Overexpression was detected in 52% to 56% (four different p53 antibodies) of 100 carcinomas studied. The concordance rate between results of immunohistochemistry and genetic analysis was 60%. No correlation was found between p53 status of the tumors and clinicopathologic parameters analyzed statistically.
Conclusions
p53 Alterations have no prognostic impact in oral squamous cell carcinomas and apparently do not represent a molecular basis for the biologic significance of the invasive tumor front. The detection of discordant p53 aberrations between primary and second primary carcinomas in some patients provide evidence for their independent origin, with possible impact on prevention and therapy. © 1998 John Wiley & Sons, Inc. Head Neck 20: 8–15, 1998. |
| doi_str_mv | 10.1002/(SICI)1097-0347(199801)20:1<8::AID-HED2>3.0.CO;2-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902332563</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79680667</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5212-16db011c66299bb116afa328accbb9d96dbd40bc396811b0a7dd9a336e711e893</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEKqXwE5C8QNAuMviRceIBIVVpmY4oDKI8JDaXG8dRDXlM7aTQf49DRsMC1IVlW-fTuUf3RNGC0RmjlD8_vFjlqyNGVRpTkaSHTKmMsiNOF-xltlgcr07is9MT_krM6Cxfv-Bxdifa3-F3x3ciYkHT5H70wPvvlFIhE74X7alEJuHsR9_edrXRQ42OoPfG-8a0PekqspkLgkXbuQZr21vjCfakvzTEttfo7bUhlesmtHNYE381YNMNnmhT10Sj07btGvQPo3sV1t482t4H0afXpx_zs_h8vVzlx-exnnPGYybLgjKmpeRKFQVjEisUPEOti0KVKshlQgstlMwYKyimZalQCGlSxkymxEH0bPLduO5qML6HxvoxC7YmxAJFuRB8LkUgn95KpmEElTIN4IcJ1K7z3pkKNs426G6AURgLAhgLgnHjMG4cpoKABxkygFAQjAWBAAr5GjhkwfTxdvpQNKbcWW4bCfqTrY5eY105bLX1O4zTbM4y9jfbT1ubm3-C3ZrrP7H-_INpPJla35tfO1N0PyCsI53Dl3dLkOrN-4uv6RI-i9-1bMXe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79680667</pqid></control><display><type>article</type><title>Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Piffkò, Jòzsef ; Bànkfalvi, Àgnes ; Tory, Kàlmàn ; Füzesi, Làszlò ; Bryne, Magne ; Öfner, Dietmar ; Kusch, Fabian ; Joos, Ulrich ; Schmid, Kurt W.</creator><creatorcontrib>Piffkò, Jòzsef ; Bànkfalvi, Àgnes ; Tory, Kàlmàn ; Füzesi, Làszlò ; Bryne, Magne ; Öfner, Dietmar ; Kusch, Fabian ; Joos, Ulrich ; Schmid, Kurt W.</creatorcontrib><description>Background
The prognostic significance of the invasive tumor front in squamous cell carcinomas has recently been recognized. The aim of the present study was to investigate possible molecular mechanisms underlying the significance of this area in oral squamous cell carcinomas.
Methods
We used immunohistochemical and molecular genetic techniques to investigate whether p53 alterations at the invasive tumor front could determine the aggressiveness of oral cancers.
Results
p53 Overexpression was detected in 52% to 56% (four different p53 antibodies) of 100 carcinomas studied. The concordance rate between results of immunohistochemistry and genetic analysis was 60%. No correlation was found between p53 status of the tumors and clinicopathologic parameters analyzed statistically.
Conclusions
p53 Alterations have no prognostic impact in oral squamous cell carcinomas and apparently do not represent a molecular basis for the biologic significance of the invasive tumor front. The detection of discordant p53 aberrations between primary and second primary carcinomas in some patients provide evidence for their independent origin, with possible impact on prevention and therapy. © 1998 John Wiley & Sons, Inc. Head Neck 20: 8–15, 1998.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/(SICI)1097-0347(199801)20:1<8::AID-HED2>3.0.CO;2-8</identifier><identifier>PMID: 9464946</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biopsy, Needle ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Chi-Square Distribution ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Genes, p53 - genetics ; Humans ; Immunohistochemistry ; invasive front ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - genetics ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Mutation ; Neoplasm Invasiveness ; oral cancer ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; p53 ; Polymerase Chain Reaction ; Prognosis ; Sensitivity and Specificity ; Survival Rate ; Tumors</subject><ispartof>Head & neck, 1998-01, Vol.20 (1), p.8-15</ispartof><rights>Copyright © 1998 John Wiley & Sons, Inc.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5212-16db011c66299bb116afa328accbb9d96dbd40bc396811b0a7dd9a336e711e893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0347%28199801%2920%3A1%3C8%3A%3AAID-HED2%3E3.0.CO%3B2-8$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0347%28199801%2920%3A1%3C8%3A%3AAID-HED2%3E3.0.CO%3B2-8$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2085181$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9464946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Piffkò, Jòzsef</creatorcontrib><creatorcontrib>Bànkfalvi, Àgnes</creatorcontrib><creatorcontrib>Tory, Kàlmàn</creatorcontrib><creatorcontrib>Füzesi, Làszlò</creatorcontrib><creatorcontrib>Bryne, Magne</creatorcontrib><creatorcontrib>Öfner, Dietmar</creatorcontrib><creatorcontrib>Kusch, Fabian</creatorcontrib><creatorcontrib>Joos, Ulrich</creatorcontrib><creatorcontrib>Schmid, Kurt W.</creatorcontrib><title>Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The prognostic significance of the invasive tumor front in squamous cell carcinomas has recently been recognized. The aim of the present study was to investigate possible molecular mechanisms underlying the significance of this area in oral squamous cell carcinomas.
Methods
We used immunohistochemical and molecular genetic techniques to investigate whether p53 alterations at the invasive tumor front could determine the aggressiveness of oral cancers.
Results
p53 Overexpression was detected in 52% to 56% (four different p53 antibodies) of 100 carcinomas studied. The concordance rate between results of immunohistochemistry and genetic analysis was 60%. No correlation was found between p53 status of the tumors and clinicopathologic parameters analyzed statistically.
Conclusions
p53 Alterations have no prognostic impact in oral squamous cell carcinomas and apparently do not represent a molecular basis for the biologic significance of the invasive tumor front. The detection of discordant p53 aberrations between primary and second primary carcinomas in some patients provide evidence for their independent origin, with possible impact on prevention and therapy. © 1998 John Wiley & Sons, Inc. Head Neck 20: 8–15, 1998.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Chi-Square Distribution</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes, p53 - genetics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>invasive front</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mutation</subject><subject>Neoplasm Invasiveness</subject><subject>oral cancer</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>p53</subject><subject>Polymerase Chain Reaction</subject><subject>Prognosis</subject><subject>Sensitivity and Specificity</subject><subject>Survival Rate</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtv1DAUhSMEKqXwE5C8QNAuMviRceIBIVVpmY4oDKI8JDaXG8dRDXlM7aTQf49DRsMC1IVlW-fTuUf3RNGC0RmjlD8_vFjlqyNGVRpTkaSHTKmMsiNOF-xltlgcr07is9MT_krM6Cxfv-Bxdifa3-F3x3ciYkHT5H70wPvvlFIhE74X7alEJuHsR9_edrXRQ42OoPfG-8a0PekqspkLgkXbuQZr21vjCfakvzTEttfo7bUhlesmtHNYE381YNMNnmhT10Sj07btGvQPo3sV1t482t4H0afXpx_zs_h8vVzlx-exnnPGYybLgjKmpeRKFQVjEisUPEOti0KVKshlQgstlMwYKyimZalQCGlSxkymxEH0bPLduO5qML6HxvoxC7YmxAJFuRB8LkUgn95KpmEElTIN4IcJ1K7z3pkKNs426G6AURgLAhgLgnHjMG4cpoKABxkygFAQjAWBAAr5GjhkwfTxdvpQNKbcWW4bCfqTrY5eY105bLX1O4zTbM4y9jfbT1ubm3-C3ZrrP7H-_INpPJla35tfO1N0PyCsI53Dl3dLkOrN-4uv6RI-i9-1bMXe</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Piffkò, Jòzsef</creator><creator>Bànkfalvi, Àgnes</creator><creator>Tory, Kàlmàn</creator><creator>Füzesi, Làszlò</creator><creator>Bryne, Magne</creator><creator>Öfner, Dietmar</creator><creator>Kusch, Fabian</creator><creator>Joos, Ulrich</creator><creator>Schmid, Kurt W.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope></search><sort><creationdate>199801</creationdate><title>Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas</title><author>Piffkò, Jòzsef ; Bànkfalvi, Àgnes ; Tory, Kàlmàn ; Füzesi, Làszlò ; Bryne, Magne ; Öfner, Dietmar ; Kusch, Fabian ; Joos, Ulrich ; Schmid, Kurt W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5212-16db011c66299bb116afa328accbb9d96dbd40bc396811b0a7dd9a336e711e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Chi-Square Distribution</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes, p53 - genetics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>invasive front</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mutation</topic><topic>Neoplasm Invasiveness</topic><topic>oral cancer</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>p53</topic><topic>Polymerase Chain Reaction</topic><topic>Prognosis</topic><topic>Sensitivity and Specificity</topic><topic>Survival Rate</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piffkò, Jòzsef</creatorcontrib><creatorcontrib>Bànkfalvi, Àgnes</creatorcontrib><creatorcontrib>Tory, Kàlmàn</creatorcontrib><creatorcontrib>Füzesi, Làszlò</creatorcontrib><creatorcontrib>Bryne, Magne</creatorcontrib><creatorcontrib>Öfner, Dietmar</creatorcontrib><creatorcontrib>Kusch, Fabian</creatorcontrib><creatorcontrib>Joos, Ulrich</creatorcontrib><creatorcontrib>Schmid, Kurt W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piffkò, Jòzsef</au><au>Bànkfalvi, Àgnes</au><au>Tory, Kàlmàn</au><au>Füzesi, Làszlò</au><au>Bryne, Magne</au><au>Öfner, Dietmar</au><au>Kusch, Fabian</au><au>Joos, Ulrich</au><au>Schmid, Kurt W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1998-01</date><risdate>1998</risdate><volume>20</volume><issue>1</issue><spage>8</spage><epage>15</epage><pages>8-15</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
The prognostic significance of the invasive tumor front in squamous cell carcinomas has recently been recognized. The aim of the present study was to investigate possible molecular mechanisms underlying the significance of this area in oral squamous cell carcinomas.
Methods
We used immunohistochemical and molecular genetic techniques to investigate whether p53 alterations at the invasive tumor front could determine the aggressiveness of oral cancers.
Results
p53 Overexpression was detected in 52% to 56% (four different p53 antibodies) of 100 carcinomas studied. The concordance rate between results of immunohistochemistry and genetic analysis was 60%. No correlation was found between p53 status of the tumors and clinicopathologic parameters analyzed statistically.
Conclusions
p53 Alterations have no prognostic impact in oral squamous cell carcinomas and apparently do not represent a molecular basis for the biologic significance of the invasive tumor front. The detection of discordant p53 aberrations between primary and second primary carcinomas in some patients provide evidence for their independent origin, with possible impact on prevention and therapy. © 1998 John Wiley & Sons, Inc. Head Neck 20: 8–15, 1998.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9464946</pmid><doi>10.1002/(SICI)1097-0347(199801)20:1<8::AID-HED2>3.0.CO;2-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 1998-01, Vol.20 (1), p.8-15 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902332563 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Biological and medical sciences Biopsy, Needle Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Chi-Square Distribution Disease-Free Survival Female Gene Expression Regulation, Neoplastic Genes, p53 - genetics Humans Immunohistochemistry invasive front Male Medical sciences Middle Aged Mouth Neoplasms - genetics Mouth Neoplasms - mortality Mouth Neoplasms - pathology Mutation Neoplasm Invasiveness oral cancer Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology p53 Polymerase Chain Reaction Prognosis Sensitivity and Specificity Survival Rate Tumors |
| title | Molecular assessment of p53 abnormalities at the invasive front of oral squamous cell carcinomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T09%3A02%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Molecular%20assessment%20of%20p53%20abnormalities%20at%20the%20invasive%20front%20of%20oral%20squamous%20cell%20carcinomas&rft.jtitle=Head%20&%20neck&rft.au=Piffk%C3%B2,%20J%C3%B2zsef&rft.date=1998-01&rft.volume=20&rft.issue=1&rft.spage=8&rft.epage=15&rft.pages=8-15&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/(SICI)1097-0347(199801)20:1%3C8::AID-HED2%3E3.0.CO;2-8&rft_dat=%3Cproquest_cross%3E79680667%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79680667&rft_id=info:pmid/9464946&rfr_iscdi=true |