Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry
The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term. Although a substantial body of data exists in re...
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creator | MOAT, Neil E LUDMAN, Peter WENDLER, Olaf HILDICK-SMITH, David DAVIES, Simon W TRIVEDI, Uday BLACKMAN, Daniel J LEVY, Richard D BRECKER, Stephen J. D BAUMBACH, Andreas DANIEL, Tim GRAY, Huon DE BELDER, Mark A MULLEN, Michael J BRIDGEWATER, Ben CUNNINGHAM, Andrew D YOUNG, Christopher P THOMAS, Martyn KOVAC, Jan SPYT, Tom MACCARTHY, Philip A |
description | The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term.
Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients.
The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010.
Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction |
doi_str_mv | 10.1016/j.jacc.2011.08.050 |
format | Article |
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Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients.
The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010.
Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction <30%), the presence of moderate/severe aortic regurgitation, and chronic obstructive pulmonary disease remained the only independent predictors of mortality in the multivariate model.
Midterm to long-term survival after TAVI was encouraging in this high-risk patient population, although a substantial proportion of patients died within the first year.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2011.08.050</identifier><identifier>PMID: 22019110</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Aged ; Aged, 80 and over ; Aortic Valve Stenosis - surgery ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Confidence intervals ; Diabetes ; Endocardial and cardiac valvular diseases ; Female ; Follow-Up Studies ; Heart ; Heart attacks ; Heart Valve Prosthesis Implantation - mortality ; Hospitals ; Humans ; Male ; Medical prognosis ; Medical sciences ; Mortality ; Postoperative Complications - epidemiology ; Prostheses ; Registries ; Stroke ; Surgery ; Transplants & implants ; Treatment Outcome ; United Kingdom - epidemiology</subject><ispartof>Journal of the American College of Cardiology, 2011-11, Vol.58 (20), p.2130-2138</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 8, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24728620$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22019110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOAT, Neil E</creatorcontrib><creatorcontrib>LUDMAN, Peter</creatorcontrib><creatorcontrib>WENDLER, Olaf</creatorcontrib><creatorcontrib>HILDICK-SMITH, David</creatorcontrib><creatorcontrib>DAVIES, Simon W</creatorcontrib><creatorcontrib>TRIVEDI, Uday</creatorcontrib><creatorcontrib>BLACKMAN, Daniel J</creatorcontrib><creatorcontrib>LEVY, Richard D</creatorcontrib><creatorcontrib>BRECKER, Stephen J. D</creatorcontrib><creatorcontrib>BAUMBACH, Andreas</creatorcontrib><creatorcontrib>DANIEL, Tim</creatorcontrib><creatorcontrib>GRAY, Huon</creatorcontrib><creatorcontrib>DE BELDER, Mark A</creatorcontrib><creatorcontrib>MULLEN, Michael J</creatorcontrib><creatorcontrib>BRIDGEWATER, Ben</creatorcontrib><creatorcontrib>CUNNINGHAM, Andrew D</creatorcontrib><creatorcontrib>YOUNG, Christopher P</creatorcontrib><creatorcontrib>THOMAS, Martyn</creatorcontrib><creatorcontrib>KOVAC, Jan</creatorcontrib><creatorcontrib>SPYT, Tom</creatorcontrib><creatorcontrib>MACCARTHY, Philip A</creatorcontrib><title>Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term.
Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients.
The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010.
Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction <30%), the presence of moderate/severe aortic regurgitation, and chronic obstructive pulmonary disease remained the only independent predictors of mortality in the multivariate model.
Midterm to long-term survival after TAVI was encouraging in this high-risk patient population, although a substantial proportion of patients died within the first year.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aortic Valve Stenosis - surgery</subject><subject>Biological and medical sciences</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Endocardial and cardiac valvular diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Heart Valve Prosthesis Implantation - mortality</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Mortality</subject><subject>Postoperative Complications - epidemiology</subject><subject>Prostheses</subject><subject>Registries</subject><subject>Stroke</subject><subject>Surgery</subject><subject>Transplants & implants</subject><subject>Treatment Outcome</subject><subject>United Kingdom - epidemiology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhi0EokvhBTggSwhRDgkex47t3lZVoauuVNRmyzFyYmfXy8ZZbKdSn68vRoCtkDggTqMZffPPzD8IvQaSA4Hy4zbf6rbNKQHIicwJJ0_QDDiXWcGVeIpmRBQ8A6LEEXoR45YQUkpQz9ERnXoUAJmhh-Xg11llQ4-vxtQOvY143iUbcBW0j61OG_szmw8huRbf6t2dxYt-v9M-6eQGj53HF269ya5d_Ia_TDXrU8RfXdrgG3tng33svUnWD9HFU1xtLF7llzmu5rcLfLLyLlmDL51fm6H_38Ef8LVdu5jC_Uv0rNO7aF8d4jFafTqvzi6y5dXnxdl8me0LAilrldCGGtIY0KUihgvLGPBSGSqpZg10LeFCd4Y3VhpBGWEUmAZDdScaUMUxev9bdx-G76ONqe5dbO1uWskOY6wVoUVBORQTefJPEiSAVJL9En37F7odxuCnO2rgwKQUJWET9eZAjU1vTb0Prtfhvn585AS8OwB68m7XTR62Lv7hmKCypKT4AZEJrpU</recordid><startdate>20111108</startdate><enddate>20111108</enddate><creator>MOAT, Neil E</creator><creator>LUDMAN, Peter</creator><creator>WENDLER, Olaf</creator><creator>HILDICK-SMITH, David</creator><creator>DAVIES, Simon W</creator><creator>TRIVEDI, Uday</creator><creator>BLACKMAN, Daniel J</creator><creator>LEVY, Richard D</creator><creator>BRECKER, Stephen J. D</creator><creator>BAUMBACH, Andreas</creator><creator>DANIEL, Tim</creator><creator>GRAY, Huon</creator><creator>DE BELDER, Mark A</creator><creator>MULLEN, Michael J</creator><creator>BRIDGEWATER, Ben</creator><creator>CUNNINGHAM, Andrew D</creator><creator>YOUNG, Christopher P</creator><creator>THOMAS, Martyn</creator><creator>KOVAC, Jan</creator><creator>SPYT, Tom</creator><creator>MACCARTHY, Philip A</creator><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20111108</creationdate><title>Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry</title><author>MOAT, Neil E ; LUDMAN, Peter ; WENDLER, Olaf ; HILDICK-SMITH, David ; DAVIES, Simon W ; TRIVEDI, Uday ; BLACKMAN, Daniel J ; LEVY, Richard D ; BRECKER, Stephen J. D ; BAUMBACH, Andreas ; DANIEL, Tim ; GRAY, Huon ; DE BELDER, Mark A ; MULLEN, Michael J ; BRIDGEWATER, Ben ; CUNNINGHAM, Andrew D ; YOUNG, Christopher P ; THOMAS, Martyn ; KOVAC, Jan ; SPYT, Tom ; MACCARTHY, Philip A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p301t-c97ad2d0bd1a690d57e441569d282a4b1fc057afd5be8d72404214a1d2af7b193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aortic Valve Stenosis - surgery</topic><topic>Biological and medical sciences</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Confidence intervals</topic><topic>Diabetes</topic><topic>Endocardial and cardiac valvular diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Heart Valve Prosthesis Implantation - mortality</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Mortality</topic><topic>Postoperative Complications - epidemiology</topic><topic>Prostheses</topic><topic>Registries</topic><topic>Stroke</topic><topic>Surgery</topic><topic>Transplants & implants</topic><topic>Treatment Outcome</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOAT, Neil E</creatorcontrib><creatorcontrib>LUDMAN, Peter</creatorcontrib><creatorcontrib>WENDLER, Olaf</creatorcontrib><creatorcontrib>HILDICK-SMITH, David</creatorcontrib><creatorcontrib>DAVIES, Simon W</creatorcontrib><creatorcontrib>TRIVEDI, Uday</creatorcontrib><creatorcontrib>BLACKMAN, Daniel J</creatorcontrib><creatorcontrib>LEVY, Richard D</creatorcontrib><creatorcontrib>BRECKER, Stephen J. 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D</au><au>BAUMBACH, Andreas</au><au>DANIEL, Tim</au><au>GRAY, Huon</au><au>DE BELDER, Mark A</au><au>MULLEN, Michael J</au><au>BRIDGEWATER, Ben</au><au>CUNNINGHAM, Andrew D</au><au>YOUNG, Christopher P</au><au>THOMAS, Martyn</au><au>KOVAC, Jan</au><au>SPYT, Tom</au><au>MACCARTHY, Philip A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2011-11-08</date><risdate>2011</risdate><volume>58</volume><issue>20</issue><spage>2130</spage><epage>2138</epage><pages>2130-2138</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>The objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term.
Although a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients.
The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010.
Survival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction <30%), the presence of moderate/severe aortic regurgitation, and chronic obstructive pulmonary disease remained the only independent predictors of mortality in the multivariate model.
Midterm to long-term survival after TAVI was encouraging in this high-risk patient population, although a substantial proportion of patients died within the first year.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>22019110</pmid><doi>10.1016/j.jacc.2011.08.050</doi><tpages>9</tpages></addata></record> |
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source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Aged Aged, 80 and over Aortic Valve Stenosis - surgery Biological and medical sciences Cardiology Cardiology. Vascular system Cardiovascular disease Chronic obstructive pulmonary disease Confidence intervals Diabetes Endocardial and cardiac valvular diseases Female Follow-Up Studies Heart Heart attacks Heart Valve Prosthesis Implantation - mortality Hospitals Humans Male Medical prognosis Medical sciences Mortality Postoperative Complications - epidemiology Prostheses Registries Stroke Surgery Transplants & implants Treatment Outcome United Kingdom - epidemiology |
title | Long-Term Outcomes After Transcatheter Aortic Valve Implantation in High-Risk Patients With Severe Aortic Stenosis: The U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry |
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