Differential effects of calcineurin inhibitors, tacrolimus and cyclosporin a, on interferon‐induced antiviral protein in human hepatocyte cells

The premise of our study is that selective inhibition of interferon (IFN) by calcineurin inhibitors contribute to the increased severity of hepatitis C virus (HCV) posttransplantation. Therefore, we examined the influence of calcineurin inhibitors in the human hepatocyte cell line on IFN‐α‐induced p...

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Veröffentlicht in:	Liver transplantation 2008-03, Vol.14 (3), p.292-298
Hauptverfasser:	Hirano, Kumi, Ichikawa, Tatsuki, Nakao, Kazuhiko, Matsumoto, Azusa, Miyaaki, Hisamitsu, Shibata, Hidetaka, Eguchi, Susumu, Takatsuki, Mitsuhisa, Ikeda, Masanori, Yamasaki, Hironori, Kato, Nobuyuki, Kanematsu, Takashi, Ishii, Nobuko, Eguchi, Katsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology Calcineurin Inhibitors Cell Line Cell Line, Tumor Cyclosporin A Cyclosporine - pharmacology eIF-2 kinase Gene Expression Regulation - drug effects Hepacivirus - drug effects Hepacivirus - metabolism Hepatitis C virus Hepatocytes Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - virology Humans Immunohistochemistry Interferon Interferon-alpha - pharmacology Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism Janus kinase Janus Kinases - metabolism Liver transplantation Nuclear transport Phosphorylation Phosphorylation - drug effects Promoters Protein kinase Recombinant Proteins Regulatory sequences Replication Signal Transduction - drug effects Signal Transduction - physiology Stat1 protein STAT1 Transcription Factor - metabolism Tacrolimus Tacrolimus - pharmacology Transcription Tyrosine Virus Replication - drug effects Western blotting
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