Evaluation of Client-Specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats with Osteoarthritis
Background:There are no validated systems for measuring pain from osteoarthritis in cats. Hypothesis:Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments. Animals:Thirteen cats older than 10 years old, w...
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| Veröffentlicht in: | Journal of veterinary internal medicine 2007-05, Vol.21 (3), p.410-416 |
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| container_title | Journal of veterinary internal medicine |
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| creator | Lascelles, B.D.X Hansen, B.D Roe, S DePuy, V Thomson, A Pierce, C.C Smith, E.S Rowinski, E |
| description | Background:There are no validated systems for measuring pain from osteoarthritis in cats.
Hypothesis:Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments.
Animals:Thirteen cats older than 10 years old, with owner‐assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks.
Methods:A collar‐mounted AM measured activity and a client‐specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2–5) or a placebo was administered in a blinded, randomized, cross‐over manner to test the assessment systems.
Results:The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n = 9) were administered meloxicam were significantly higher than at baseline (P= .02) but not after placebo (P= .06). Baseline activity counts were not significantly different from placebo (P= .6). The CSOM data (n = 13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P= .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042).
Conclusions and Clinical Importance: Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies. |
| doi_str_mv | 10.1111/j.1939-1676.2007.tb02983.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_proquest_miscellaneous_902331407</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902331407</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3120-5e51dde0f3d58ffc5797b502ef0c1f2e0da01fb3b0522566696bdb41264e174d3</originalsourceid><addsrcrecordid>eNqVkU1v0zAYgCMEYmXwF8DiAKeE13ZsN1zQVG1laKWIfXC0nMTeXNK42M7W_ntcpYwbEr7Ykh8_r-Qny95iKHBaH1YFrmiVYy54QQBEEWsg1ZQW2yfZ5PHqaTaBaYVzzks4yl6EsAIgjDHxPDvCgjFSluUk253eq25Q0boeOYNmndV9zC83urHGNmg5xMatNVpoFQavA1J9i06aaO9t3KGF62103va3KLo_DPqmbI--62QyKJ1mKgb0YOMdWoaonfLxzttow8vsmVFd0K8O-3F2fXZ6NfucXyzn57OTi7yhmEDONMNtq8HQlk2NaZioRM2AaAMNNkRDqwCbmtbACGGc84rXbV1iwkuNRdnS4-z96N1492vQIcq1DY3uOtVrNwRZAaEUlyAS-e6fpAAODBOcwI8j2HgXgtdGbrxdK7-TGOQ-kVzJfQe57yD3ieQhkdymx68PU4Z6rdu_Tw9NEvBpBB5sp3f_oZZfbs4XJYZkyEeDTT--fTQo_1NyQQWTP77OJczFlbhZgDxL_JuRN8pJdettkNeXBDAFmKYxjNDffi66sQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70605121</pqid></control><display><type>article</type><title>Evaluation of Client-Specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats with Osteoarthritis</title><source>Wiley Online Library (Open Access Collection)</source><creator>Lascelles, B.D.X ; Hansen, B.D ; Roe, S ; DePuy, V ; Thomson, A ; Pierce, C.C ; Smith, E.S ; Rowinski, E</creator><creatorcontrib>Lascelles, B.D.X ; Hansen, B.D ; Roe, S ; DePuy, V ; Thomson, A ; Pierce, C.C ; Smith, E.S ; Rowinski, E</creatorcontrib><description>Background:There are no validated systems for measuring pain from osteoarthritis in cats.
Hypothesis:Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments.
Animals:Thirteen cats older than 10 years old, with owner‐assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks.
Methods:A collar‐mounted AM measured activity and a client‐specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2–5) or a placebo was administered in a blinded, randomized, cross‐over manner to test the assessment systems.
Results:The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n = 9) were administered meloxicam were significantly higher than at baseline (P= .02) but not after placebo (P= .06). Baseline activity counts were not significantly different from placebo (P= .6). The CSOM data (n = 13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P= .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042).
Conclusions and Clinical Importance: Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.2007.tb02983.x</identifier><identifier>PMID: 17552444</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Activity ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Cat Diseases ; Cats ; Cross-Over Studies ; Degenerative joint disease ; Double-Blind Method ; Feline ; Female ; Male ; Meloxicam ; osteoarthritis ; Osteoarthritis - complications ; Osteoarthritis - veterinary ; Owner ; pain ; Pain - drug therapy ; Pain - etiology ; Pain - veterinary ; Pain Measurement - methods ; Pain Measurement - veterinary ; Quality of Life ; Severity of Illness Index ; Subjective assessment ; Surveys and Questionnaires ; therapeutics ; Thiazines - therapeutic use ; Thiazoles - therapeutic use ; Treatment Outcome</subject><ispartof>Journal of veterinary internal medicine, 2007-05, Vol.21 (3), p.410-416</ispartof><rights>2007 American College of Veterinary Internal Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3120-5e51dde0f3d58ffc5797b502ef0c1f2e0da01fb3b0522566696bdb41264e174d3</citedby><cites>FETCH-LOGICAL-c3120-5e51dde0f3d58ffc5797b502ef0c1f2e0da01fb3b0522566696bdb41264e174d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.2007.tb02983.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.2007.tb02983.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.2007.tb02983.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17552444$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lascelles, B.D.X</creatorcontrib><creatorcontrib>Hansen, B.D</creatorcontrib><creatorcontrib>Roe, S</creatorcontrib><creatorcontrib>DePuy, V</creatorcontrib><creatorcontrib>Thomson, A</creatorcontrib><creatorcontrib>Pierce, C.C</creatorcontrib><creatorcontrib>Smith, E.S</creatorcontrib><creatorcontrib>Rowinski, E</creatorcontrib><title>Evaluation of Client-Specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats with Osteoarthritis</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Background:There are no validated systems for measuring pain from osteoarthritis in cats.
Hypothesis:Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments.
Animals:Thirteen cats older than 10 years old, with owner‐assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks.
Methods:A collar‐mounted AM measured activity and a client‐specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2–5) or a placebo was administered in a blinded, randomized, cross‐over manner to test the assessment systems.
Results:The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n = 9) were administered meloxicam were significantly higher than at baseline (P= .02) but not after placebo (P= .06). Baseline activity counts were not significantly different from placebo (P= .6). The CSOM data (n = 13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P= .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042).
Conclusions and Clinical Importance: Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies.</description><subject>Activity</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Cat Diseases</subject><subject>Cats</subject><subject>Cross-Over Studies</subject><subject>Degenerative joint disease</subject><subject>Double-Blind Method</subject><subject>Feline</subject><subject>Female</subject><subject>Male</subject><subject>Meloxicam</subject><subject>osteoarthritis</subject><subject>Osteoarthritis - complications</subject><subject>Osteoarthritis - veterinary</subject><subject>Owner</subject><subject>pain</subject><subject>Pain - drug therapy</subject><subject>Pain - etiology</subject><subject>Pain - veterinary</subject><subject>Pain Measurement - methods</subject><subject>Pain Measurement - veterinary</subject><subject>Quality of Life</subject><subject>Severity of Illness Index</subject><subject>Subjective assessment</subject><subject>Surveys and Questionnaires</subject><subject>therapeutics</subject><subject>Thiazines - therapeutic use</subject><subject>Thiazoles - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkU1v0zAYgCMEYmXwF8DiAKeE13ZsN1zQVG1laKWIfXC0nMTeXNK42M7W_ntcpYwbEr7Ykh8_r-Qny95iKHBaH1YFrmiVYy54QQBEEWsg1ZQW2yfZ5PHqaTaBaYVzzks4yl6EsAIgjDHxPDvCgjFSluUk253eq25Q0boeOYNmndV9zC83urHGNmg5xMatNVpoFQavA1J9i06aaO9t3KGF62103va3KLo_DPqmbI--62QyKJ1mKgb0YOMdWoaonfLxzttow8vsmVFd0K8O-3F2fXZ6NfucXyzn57OTi7yhmEDONMNtq8HQlk2NaZioRM2AaAMNNkRDqwCbmtbACGGc84rXbV1iwkuNRdnS4-z96N1492vQIcq1DY3uOtVrNwRZAaEUlyAS-e6fpAAODBOcwI8j2HgXgtdGbrxdK7-TGOQ-kVzJfQe57yD3ieQhkdymx68PU4Z6rdu_Tw9NEvBpBB5sp3f_oZZfbs4XJYZkyEeDTT--fTQo_1NyQQWTP77OJczFlbhZgDxL_JuRN8pJdettkNeXBDAFmKYxjNDffi66sQ</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Lascelles, B.D.X</creator><creator>Hansen, B.D</creator><creator>Roe, S</creator><creator>DePuy, V</creator><creator>Thomson, A</creator><creator>Pierce, C.C</creator><creator>Smith, E.S</creator><creator>Rowinski, E</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>200705</creationdate><title>Evaluation of Client-Specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats with Osteoarthritis</title><author>Lascelles, B.D.X ; Hansen, B.D ; Roe, S ; DePuy, V ; Thomson, A ; Pierce, C.C ; Smith, E.S ; Rowinski, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3120-5e51dde0f3d58ffc5797b502ef0c1f2e0da01fb3b0522566696bdb41264e174d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Activity</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Cat Diseases</topic><topic>Cats</topic><topic>Cross-Over Studies</topic><topic>Degenerative joint disease</topic><topic>Double-Blind Method</topic><topic>Feline</topic><topic>Female</topic><topic>Male</topic><topic>Meloxicam</topic><topic>osteoarthritis</topic><topic>Osteoarthritis - complications</topic><topic>Osteoarthritis - veterinary</topic><topic>Owner</topic><topic>pain</topic><topic>Pain - drug therapy</topic><topic>Pain - etiology</topic><topic>Pain - veterinary</topic><topic>Pain Measurement - methods</topic><topic>Pain Measurement - veterinary</topic><topic>Quality of Life</topic><topic>Severity of Illness Index</topic><topic>Subjective assessment</topic><topic>Surveys and Questionnaires</topic><topic>therapeutics</topic><topic>Thiazines - therapeutic use</topic><topic>Thiazoles - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lascelles, B.D.X</creatorcontrib><creatorcontrib>Hansen, B.D</creatorcontrib><creatorcontrib>Roe, S</creatorcontrib><creatorcontrib>DePuy, V</creatorcontrib><creatorcontrib>Thomson, A</creatorcontrib><creatorcontrib>Pierce, C.C</creatorcontrib><creatorcontrib>Smith, E.S</creatorcontrib><creatorcontrib>Rowinski, E</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Journal of veterinary internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Lascelles, B.D.X</au><au>Hansen, B.D</au><au>Roe, S</au><au>DePuy, V</au><au>Thomson, A</au><au>Pierce, C.C</au><au>Smith, E.S</au><au>Rowinski, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of Client-Specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats with Osteoarthritis</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>2007-05</date><risdate>2007</risdate><volume>21</volume><issue>3</issue><spage>410</spage><epage>416</epage><pages>410-416</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Background:There are no validated systems for measuring pain from osteoarthritis in cats.
Hypothesis:Owner subjective assessments and an activity monitor (AM) can be used to detect pain in cats with osteoarthritis and to assess efficacy of treatments.
Animals:Thirteen cats older than 10 years old, with owner‐assessed decreases in activity, painful arthritic joints, and clinically normal blood work were included and evaluated for 3 weeks.
Methods:A collar‐mounted AM measured activity and a client‐specific outcome measure (CSOM) questionnaire characterized the severity of impairment. Overall global quality of life was also evaluated for each treatment. In weeks 2 and 3, meloxicam (0.1 mg/kg, day 1; 0.05 mg/kg, days 2–5) or a placebo was administered in a blinded, randomized, cross‐over manner to test the assessment systems.
Results:The cats had a median of 4 arthritic appendicular joints. Activity counts for the week when cats (complete data on activity; n = 9) were administered meloxicam were significantly higher than at baseline (P= .02) but not after placebo (P= .06). Baseline activity counts were not significantly different from placebo (P= .6). The CSOM data (n = 13) showed that owners considered their cats to be more active on meloxicam compared with baseline (P= .001) and placebo (P < .004), and more active on placebo than at baseline (P < .01). Global quality of life improved significantly with meloxicam (P < .042).
Conclusions and Clinical Importance: Both an AM and a CSOM system can detect behavior associated with pain relief in cats that are arthritic. Objective activity data might allow subjective assessment systems to be validated for use in clinical studies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17552444</pmid><doi>10.1111/j.1939-1676.2007.tb02983.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of veterinary internal medicine, 2007-05, Vol.21 (3), p.410-416 |
| issn | 0891-6640 1939-1676 |
| language | eng |
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| subjects | Activity Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Cat Diseases Cats Cross-Over Studies Degenerative joint disease Double-Blind Method Feline Female Male Meloxicam osteoarthritis Osteoarthritis - complications Osteoarthritis - veterinary Owner pain Pain - drug therapy Pain - etiology Pain - veterinary Pain Measurement - methods Pain Measurement - veterinary Quality of Life Severity of Illness Index Subjective assessment Surveys and Questionnaires therapeutics Thiazines - therapeutic use Thiazoles - therapeutic use Treatment Outcome |
| title | Evaluation of Client-Specific Outcome Measures and Activity Monitoring to Measure Pain Relief in Cats with Osteoarthritis |
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