Forced vital capacity in two large outpatient populations with chronic spinal cord injury
To determine the expected vital capacity in persons with chronic spinal cord injury (SCI) in relation to injury level, completeness of injury, smoking and duration of injury, as an aid to diagnosis and management of respiratory complications. A New York City veterans' hospital and a Los Angeles...
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| Veröffentlicht in: | Spinal cord 2001-05, Vol.39 (5), p.263-268 |
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| creator | LINN, W. S SPUNGEN, A. M GONG, H. JR ADKINS, R. H BAUMAN, W. A WATERS, R. L |
| description | To determine the expected vital capacity in persons with chronic spinal cord injury (SCI) in relation to injury level, completeness of injury, smoking and duration of injury, as an aid to diagnosis and management of respiratory complications.
A New York City veterans' hospital and a Los Angeles public rehabilitation hospital.
Case series from the two hospitals were pooled. Participants (adult outpatients with SCI of duration >1 year, not ventilator-dependent) were evaluated by conventional forced expiratory spirometry. Cross-sectional analysis was performed, using multiple regression, on the entire population and defined subgroups. The principal outcome measure was forced vital capacity (FVC).
In the subjects with complete-motor lesions, FVC ranged from near 100% of normal predicted values in the group with low paraplegia, to less than 50% in those with high tetraplegia. Incomplete lesions mitigated FVC loss in tetraplegia. In subjects with paraplegia, longer duration of injury was associated with greater loss, and smoking-related loss was evident at older but not at younger ages, presumably due to greater pack years in older subjects.
Vital capacity/SCI level relationships determined here may have diagnostic and prognostic value. Smoking-related FVC loss is important in persons with SCI as in others, although at higher levels it may be obscured by SCI-related loss. |
| doi_str_mv | 10.1038/sj.sc.3101155 |
| format | Article |
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A New York City veterans' hospital and a Los Angeles public rehabilitation hospital.
Case series from the two hospitals were pooled. Participants (adult outpatients with SCI of duration >1 year, not ventilator-dependent) were evaluated by conventional forced expiratory spirometry. Cross-sectional analysis was performed, using multiple regression, on the entire population and defined subgroups. The principal outcome measure was forced vital capacity (FVC).
In the subjects with complete-motor lesions, FVC ranged from near 100% of normal predicted values in the group with low paraplegia, to less than 50% in those with high tetraplegia. Incomplete lesions mitigated FVC loss in tetraplegia. In subjects with paraplegia, longer duration of injury was associated with greater loss, and smoking-related loss was evident at older but not at younger ages, presumably due to greater pack years in older subjects.
Vital capacity/SCI level relationships determined here may have diagnostic and prognostic value. Smoking-related FVC loss is important in persons with SCI as in others, although at higher levels it may be obscured by SCI-related loss.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/sj.sc.3101155</identifier><identifier>PMID: 11438842</identifier><identifier>CODEN: SPCOFM</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cerebrospinal fluid. Meninges. Spinal cord ; Cohort Studies ; Cross-Sectional Studies ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Outpatients ; Paraplegia ; Probability ; Prognosis ; Quadriplegia ; Regression Analysis ; Respiratory Function Tests ; Respiratory Tract Diseases - diagnosis ; Respiratory Tract Diseases - etiology ; Severity of Illness Index ; Spinal Cord Injuries - complications ; Spirometry ; Vital Capacity</subject><ispartof>Spinal cord, 2001-05, Vol.39 (5), p.263-268</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2001</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-8d19c340a69224ef29dca6a987380d85d7eadd424fb3b4dc62ef66604c5d64743</citedby><cites>FETCH-LOGICAL-c416t-8d19c340a69224ef29dca6a987380d85d7eadd424fb3b4dc62ef66604c5d64743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1006179$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11438842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LINN, W. S</creatorcontrib><creatorcontrib>SPUNGEN, A. M</creatorcontrib><creatorcontrib>GONG, H. JR</creatorcontrib><creatorcontrib>ADKINS, R. H</creatorcontrib><creatorcontrib>BAUMAN, W. A</creatorcontrib><creatorcontrib>WATERS, R. L</creatorcontrib><title>Forced vital capacity in two large outpatient populations with chronic spinal cord injury</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><description>To determine the expected vital capacity in persons with chronic spinal cord injury (SCI) in relation to injury level, completeness of injury, smoking and duration of injury, as an aid to diagnosis and management of respiratory complications.
A New York City veterans' hospital and a Los Angeles public rehabilitation hospital.
Case series from the two hospitals were pooled. Participants (adult outpatients with SCI of duration >1 year, not ventilator-dependent) were evaluated by conventional forced expiratory spirometry. Cross-sectional analysis was performed, using multiple regression, on the entire population and defined subgroups. The principal outcome measure was forced vital capacity (FVC).
In the subjects with complete-motor lesions, FVC ranged from near 100% of normal predicted values in the group with low paraplegia, to less than 50% in those with high tetraplegia. Incomplete lesions mitigated FVC loss in tetraplegia. In subjects with paraplegia, longer duration of injury was associated with greater loss, and smoking-related loss was evident at older but not at younger ages, presumably due to greater pack years in older subjects.
Vital capacity/SCI level relationships determined here may have diagnostic and prognostic value. Smoking-related FVC loss is important in persons with SCI as in others, although at higher levels it may be obscured by SCI-related loss.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid. Meninges. Spinal cord</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Outpatients</subject><subject>Paraplegia</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Quadriplegia</subject><subject>Regression Analysis</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Tract Diseases - diagnosis</subject><subject>Respiratory Tract Diseases - etiology</subject><subject>Severity of Illness Index</subject><subject>Spinal Cord Injuries - complications</subject><subject>Spirometry</subject><subject>Vital Capacity</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90T1r3TAUBmBRUpqPduxaRCjJ5Ft9WZbGEJqkEOjSDp2EriQ3Mr6WoyMn3H9fXWJoydBJZ3jOC0cvQh8p2VDC1RcYNuA2nBJK2_YNOqGik00rmTiqM5esEVzzY3QKMBBCNNXqHTqmVHClBDtBv25SdsHjp1jsiJ2drYtlj-OEy3PCo82_A05LmW2JYSp4TvMy1jlNgJ9jecDuIacpOgxznA4BKfu6PCx5_x697e0I4cP6nqGfN19_XN81999vv11f3TdOUFka5al2XBArNWMi9Ex7Z6XVquOKeNX6LljvBRP9lm-Fd5KFXkpJhGu9FJ3gZ-jyJXfO6XEJUMwuggvjaKeQFjCaMM5Jp1iVF_-VHdH1f8gh8vwVHNKS631gGNOiCtJV1LwglxNADr2Zc9zZvDeUmEM1BgYDzqzVVP9pDV22u-D_6rWLCj6vwIKzY5_t5CL8k0ok7TT_AxzOlt4</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>LINN, W. 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S</au><au>SPUNGEN, A. M</au><au>GONG, H. JR</au><au>ADKINS, R. H</au><au>BAUMAN, W. A</au><au>WATERS, R. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Forced vital capacity in two large outpatient populations with chronic spinal cord injury</atitle><jtitle>Spinal cord</jtitle><addtitle>Spinal Cord</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>39</volume><issue>5</issue><spage>263</spage><epage>268</epage><pages>263-268</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><coden>SPCOFM</coden><abstract>To determine the expected vital capacity in persons with chronic spinal cord injury (SCI) in relation to injury level, completeness of injury, smoking and duration of injury, as an aid to diagnosis and management of respiratory complications.
A New York City veterans' hospital and a Los Angeles public rehabilitation hospital.
Case series from the two hospitals were pooled. Participants (adult outpatients with SCI of duration >1 year, not ventilator-dependent) were evaluated by conventional forced expiratory spirometry. Cross-sectional analysis was performed, using multiple regression, on the entire population and defined subgroups. The principal outcome measure was forced vital capacity (FVC).
In the subjects with complete-motor lesions, FVC ranged from near 100% of normal predicted values in the group with low paraplegia, to less than 50% in those with high tetraplegia. Incomplete lesions mitigated FVC loss in tetraplegia. In subjects with paraplegia, longer duration of injury was associated with greater loss, and smoking-related loss was evident at older but not at younger ages, presumably due to greater pack years in older subjects.
Vital capacity/SCI level relationships determined here may have diagnostic and prognostic value. Smoking-related FVC loss is important in persons with SCI as in others, although at higher levels it may be obscured by SCI-related loss.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>11438842</pmid><doi>10.1038/sj.sc.3101155</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Spinal cord, 2001-05, Vol.39 (5), p.263-268 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Biological and medical sciences Cerebrospinal fluid. Meninges. Spinal cord Cohort Studies Cross-Sectional Studies Female Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Outpatients Paraplegia Probability Prognosis Quadriplegia Regression Analysis Respiratory Function Tests Respiratory Tract Diseases - diagnosis Respiratory Tract Diseases - etiology Severity of Illness Index Spinal Cord Injuries - complications Spirometry Vital Capacity |
| title | Forced vital capacity in two large outpatient populations with chronic spinal cord injury |
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