Oxygen-dependent regulation of nitric oxide production by inducible nitric oxide synthase

Inducible nitric oxide synthase (iNOS) catalyzes the reaction that converts the substrates O 2 and l-arginine to the products nitric oxide (NO) and l-citrulline. Macrophages, and many other cell types, upregulate and express iNOS primarily in response to inflammatory stimuli. Physiological and patho...

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Veröffentlicht in:	Free radical biology & medicine 2011-12, Vol.51 (11), p.1952-1965
Hauptverfasser:	Robinson, Mary A., Baumgardner, James E., Otto, Cynthia M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cell culture Cell culture techniques citrulline cytokines dimerization Free radicals gene expression regulation Humans Hypoxia Hypoxia-inducible factor hypoxia-inducible factor 1 in vitro studies inducible nitric oxide synthase inflammation iNOS l-Arginine Macrophages messenger RNA NF-κB Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - metabolism Oxygen Oxygen - metabolism Substrate dependence transcription (genetics) transcription factor NF-kappa B
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