Response of canine mast cell tumors to treatment with oral prednisone
Twenty‐five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for t...
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| Veröffentlicht in: | Journal of veterinary internal medicine 1994-11, Vol.8 (6), p.406-408 |
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| container_title | Journal of veterinary internal medicine |
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| creator | McCaw, D.L. (University of Missouri, Columbia, MO.) Miller, M.A Ogilvie, G.K Withrow, S.J Brewer, W.G. Jr Klein, M.K Bell, F.W Anderson, S.K |
| description | Twenty‐five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy. |
| doi_str_mv | 10.1111/j.1939-1676.1994.tb03259.x |
| format | Article |
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(University of Missouri, Columbia, MO.) ; Miller, M.A ; Ogilvie, G.K ; Withrow, S.J ; Brewer, W.G. Jr ; Klein, M.K ; Bell, F.W ; Anderson, S.K</creator><creatorcontrib>McCaw, D.L. (University of Missouri, Columbia, MO.) ; Miller, M.A ; Ogilvie, G.K ; Withrow, S.J ; Brewer, W.G. Jr ; Klein, M.K ; Bell, F.W ; Anderson, S.K</creatorcontrib><description>Twenty‐five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.</description><identifier>ISSN: 0891-6640</identifier><identifier>EISSN: 1939-1676</identifier><identifier>DOI: 10.1111/j.1939-1676.1994.tb03259.x</identifier><identifier>PMID: 7884726</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Animals ; CELULAS FIBROSAS ; CHIEN ; Dog Diseases - drug therapy ; DOGS ; DRUG THERAPY ; Female ; GLUCOCORTICOIDE ; GLUCOCORTICOIDES ; GLUCOCORTICOIDS ; Male ; MALIGNANT COURSE ; MAST CELLS ; Mast-Cell Sarcoma - drug therapy ; Mast-Cell Sarcoma - veterinary ; MASTOCYTE ; NEOPLASM REGRESSION ; Neoplasm Staging - veterinary ; NEOPLASMAS ; NEOPLASME ; NEOPLASMS ; PATHOGENESE ; PATHOGENESIS ; PATOGENESIS ; PERRO ; Prednisone - administration & dosage ; Prednisone - therapeutic use ; Prospective Studies ; RELAPSE ; Remission Induction ; Skin Neoplasms - drug therapy ; Skin Neoplasms - veterinary ; SUPERVIVENCIA ; SURVIE ; SURVIVAL ; TERAPEUTICA MEDICAMENTOSA ; THERAPEUTIQUE MEDICAMENTEUSE</subject><ispartof>Journal of veterinary internal medicine, 1994-11, Vol.8 (6), p.406-408</ispartof><rights>1994 American College of Veterinary Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5116-707e60e6bd192c4b47dc33fd3fa8ab6c0ff0f18c206a7eda9abaeebe8b9fc6e83</citedby><cites>FETCH-LOGICAL-c5116-707e60e6bd192c4b47dc33fd3fa8ab6c0ff0f18c206a7eda9abaeebe8b9fc6e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1939-1676.1994.tb03259.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1939-1676.1994.tb03259.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1939-1676.1994.tb03259.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7884726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCaw, D.L. (University of Missouri, Columbia, MO.)</creatorcontrib><creatorcontrib>Miller, M.A</creatorcontrib><creatorcontrib>Ogilvie, G.K</creatorcontrib><creatorcontrib>Withrow, S.J</creatorcontrib><creatorcontrib>Brewer, W.G. Jr</creatorcontrib><creatorcontrib>Klein, M.K</creatorcontrib><creatorcontrib>Bell, F.W</creatorcontrib><creatorcontrib>Anderson, S.K</creatorcontrib><title>Response of canine mast cell tumors to treatment with oral prednisone</title><title>Journal of veterinary internal medicine</title><addtitle>J Vet Intern Med</addtitle><description>Twenty‐five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>CELULAS FIBROSAS</subject><subject>CHIEN</subject><subject>Dog Diseases - drug therapy</subject><subject>DOGS</subject><subject>DRUG THERAPY</subject><subject>Female</subject><subject>GLUCOCORTICOIDE</subject><subject>GLUCOCORTICOIDES</subject><subject>GLUCOCORTICOIDS</subject><subject>Male</subject><subject>MALIGNANT COURSE</subject><subject>MAST CELLS</subject><subject>Mast-Cell Sarcoma - drug therapy</subject><subject>Mast-Cell Sarcoma - veterinary</subject><subject>MASTOCYTE</subject><subject>NEOPLASM REGRESSION</subject><subject>Neoplasm Staging - veterinary</subject><subject>NEOPLASMAS</subject><subject>NEOPLASME</subject><subject>NEOPLASMS</subject><subject>PATHOGENESE</subject><subject>PATHOGENESIS</subject><subject>PATOGENESIS</subject><subject>PERRO</subject><subject>Prednisone - administration & dosage</subject><subject>Prednisone - therapeutic use</subject><subject>Prospective Studies</subject><subject>RELAPSE</subject><subject>Remission Induction</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - veterinary</subject><subject>SUPERVIVENCIA</subject><subject>SURVIE</subject><subject>SURVIVAL</subject><subject>TERAPEUTICA MEDICAMENTOSA</subject><subject>THERAPEUTIQUE MEDICAMENTEUSE</subject><issn>0891-6640</issn><issn>1939-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1v0zAUhq0JNLqxP4CEZHHBrlLsOPEHNxNMowx1m9Qxdmk5zjGkJHGxXa379yRK1UskfGNL73PeYz0IvaNkTofzYT2niqmMcsGHlyrmqSIsL9V8d4Rmh-gFmhGpaMZ5QV6hkxjXhORlWYpjdCykLETOZ-hqBXHj-wjYO2xN3_SAOxMTttC2OG07HyJOHqcAJnXQJ_zUpF_YB9PiTYC6b6Lv4TV66Uwb4Wx_n6KHL1ffL79my7vF9eWnZWZLSnkmiABOgFc1VbktqkLUljFXM2ekqbglzhFHpc0JNwJqo0xlACqQlXKWg2Sn6Hzq3QT_Zwsx6a6J409ND34btSI5y6VQYiDf_5MUQijCmBrAjxNog48xgNOb0HQmPGtK9Ghbr_WoVI9K9Whb723r3TD8dr9lW3VQH0b3eof8Ysqfmhae_6NZf_txfVOQsSGbGpqYYHdoMOG35oKJUj_eLvRitbh5vP281KuBfzPxznhtfoYm6od7VfJcyYL9BbtBqP0</recordid><startdate>199411</startdate><enddate>199411</enddate><creator>McCaw, D.L. 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Jr</au><au>Klein, M.K</au><au>Bell, F.W</au><au>Anderson, S.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of canine mast cell tumors to treatment with oral prednisone</atitle><jtitle>Journal of veterinary internal medicine</jtitle><addtitle>J Vet Intern Med</addtitle><date>1994-11</date><risdate>1994</risdate><volume>8</volume><issue>6</issue><spage>406</spage><epage>408</epage><pages>406-408</pages><issn>0891-6640</issn><eissn>1939-1676</eissn><abstract>Twenty‐five dogs with naturally occurring mast cell tumors were treated with daily oral prednisone (1 mg/kg) for 28 days. Five dogs (20%) had reduction in tumor volume and were considered responders. Four of these underwent partial remission and one underwent complete remission. Survival times for the five responders were 3, 5, 6, 7.5, and greater than 28 months, respectively. We therefore conclude that prednisone is effective in some canine mast cell tumors. Further studies are indicated to determine the most effective dose of prednisone, the appropriate duration of treatment, and the efficacy in more benign mast cell tumors, and in combination with other forms of therapy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7884726</pmid><doi>10.1111/j.1939-1676.1994.tb03259.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0891-6640 |
| ispartof | Journal of veterinary internal medicine, 1994-11, Vol.8 (6), p.406-408 |
| issn | 0891-6640 1939-1676 |
| language | eng |
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| source | Wiley Online Library Open Access |
| subjects | Administration, Oral Animals CELULAS FIBROSAS CHIEN Dog Diseases - drug therapy DOGS DRUG THERAPY Female GLUCOCORTICOIDE GLUCOCORTICOIDES GLUCOCORTICOIDS Male MALIGNANT COURSE MAST CELLS Mast-Cell Sarcoma - drug therapy Mast-Cell Sarcoma - veterinary MASTOCYTE NEOPLASM REGRESSION Neoplasm Staging - veterinary NEOPLASMAS NEOPLASME NEOPLASMS PATHOGENESE PATHOGENESIS PATOGENESIS PERRO Prednisone - administration & dosage Prednisone - therapeutic use Prospective Studies RELAPSE Remission Induction Skin Neoplasms - drug therapy Skin Neoplasms - veterinary SUPERVIVENCIA SURVIE SURVIVAL TERAPEUTICA MEDICAMENTOSA THERAPEUTIQUE MEDICAMENTEUSE |
| title | Response of canine mast cell tumors to treatment with oral prednisone |
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