The apicoplast
Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic...
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| Veröffentlicht in: | Protoplasma 2011-10, Vol.248 (4), p.641-650 |
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| container_title | Protoplasma |
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| creator | McFadden, Geoffrey Ian |
| description | Parasites like malaria and
Toxoplasma
possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin. In this review, the discovery of the apicoplast and its integration, function and purpose are explored. New insights into the apicoplast fatty acid biosynthesis pathway and some novel roles of the apicoplast in vaccine development are reviewed. |
| doi_str_mv | 10.1007/s00709-010-0250-5 |
| format | Article |
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immunology</subject><subject>Protozoan Infections - parasitology</subject><subject>Protozoan Infections - therapy</subject><subject>Review</subject><subject>Symbiosis</subject><subject>Toxoplasma</subject><subject>Zoology</subject><issn>0033-183X</issn><issn>1615-6102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kM1LAzEQxYMotn7dvYjgQS_RmWTzdZTiFxS8VPAWsmlWW7bdNeke_O9N3Soi6GXmML_3HvMIOUa4RAB1lfIAQwGBAhNAxRYZokRBJQLbJkMAzilq_jwgeynNAUAwELtkwBClkJINydHkNZy6duabtnZpdUB2KlencLjZ--Tp9mYyuqfjx7uH0fWY-qJQK-pclpcFAyWd8pJzZ0TQ3KOqppXMKSXT4NEULGSgqnSpK60MZ1wVIFHyfXLe-7axeetCWtnFLPlQ124Zmi5ZAwy0lFJn8uJfEvNLXGrNTEbPfqHzpovL_IdFMEJwYz6jsad8bFKKobJtnC1cfM-QXddq-1ptrtWua7Uia042zl25CNNvxVePGWA9kPJp-RLiz-i_XD8AhNN9Uw</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>McFadden, Geoffrey Ian</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>The apicoplast</title><author>McFadden, Geoffrey Ian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-aa656b42076a7c633a95e83c17fdf6052b280c1942e6a7ff8b8f8793237406163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antiprotozoal Agents - 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| ispartof | Protoplasma, 2011-10, Vol.248 (4), p.641-650 |
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| language | eng |
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| subjects | Antiprotozoal Agents - pharmacology Apicomplexa - drug effects Apicomplexa - immunology Apicomplexa - metabolism Apicomplexa - physiology Biomedical and Life Sciences Cell Biology Fatty Acids - biosynthesis Immunity Intracellular Membranes - immunology Intracellular Membranes - metabolism Intracellular Membranes - physiology Life Sciences Microscopy, Electron, Transmission Plant Sciences Plastids - drug effects Plastids - immunology Plastids - metabolism Plastids - physiology Plastids - ultrastructure Protein Transport Protozoan Infections - immunology Protozoan Infections - parasitology Protozoan Infections - therapy Review Symbiosis Toxoplasma Zoology |
| title | The apicoplast |
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