Transcriptional dynamics of the sex chromosomes and the search for offspring sex-specific antigens in sperm
The ability to pre-select offspring sex via separation of X- and Y-bearing sperm would have profound ramifications for the animal husbandry industry. No fully satisfactory method is as yet available for any species, although flow sorting is commercially viable for cattle. The discovery of antigens t...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2011-11, Vol.142 (5), p.609-619 |
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| creator | Ellis, Peter J I Yu, Yong Zhang, Shujun |
| description | The ability to pre-select offspring sex via separation of X- and Y-bearing sperm would have profound ramifications for the animal husbandry industry. No fully satisfactory method is as yet available for any species, although flow sorting is commercially viable for cattle. The discovery of antigens that distinguish X- and Y-bearing sperm, i.e. offspring sex-specific antigens (OSSAs), would allow for batched immunological separation of sperm and thus enable a safer, more widely applicable and high-throughput means of sperm sorting. This review addresses the basic processes of spermatogenesis that have complicated the search for OSSAs, in particular the syncytial development of male germ cells, and the transcriptional dynamics of the sex chromosomes during and after meiosis. We survey the various approaches taken to discover OSSA and propose that a whole-genome transcriptional approach to the problem is the most promising avenue for future research in the field. |
| doi_str_mv | 10.1530/REP-11-0228 |
| format | Article |
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No fully satisfactory method is as yet available for any species, although flow sorting is commercially viable for cattle. The discovery of antigens that distinguish X- and Y-bearing sperm, i.e. offspring sex-specific antigens (OSSAs), would allow for batched immunological separation of sperm and thus enable a safer, more widely applicable and high-throughput means of sperm sorting. This review addresses the basic processes of spermatogenesis that have complicated the search for OSSAs, in particular the syncytial development of male germ cells, and the transcriptional dynamics of the sex chromosomes during and after meiosis. 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No fully satisfactory method is as yet available for any species, although flow sorting is commercially viable for cattle. The discovery of antigens that distinguish X- and Y-bearing sperm, i.e. offspring sex-specific antigens (OSSAs), would allow for batched immunological separation of sperm and thus enable a safer, more widely applicable and high-throughput means of sperm sorting. This review addresses the basic processes of spermatogenesis that have complicated the search for OSSAs, in particular the syncytial development of male germ cells, and the transcriptional dynamics of the sex chromosomes during and after meiosis. We survey the various approaches taken to discover OSSA and propose that a whole-genome transcriptional approach to the problem is the most promising avenue for future research in the field.</description><subject>animal husbandry</subject><subject>Animals</subject><subject>antigens</subject><subject>Antigens - genetics</subject><subject>Antigens - isolation & purification</subject><subject>Antigens - metabolism</subject><subject>Cattle</subject><subject>Female</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation</subject><subject>Germ cells</subject><subject>Humans</subject><subject>Husbandry</subject><subject>Kinetics</subject><subject>Male</subject><subject>Meiosis</subject><subject>Models, Biological</subject><subject>progeny</subject><subject>Review</subject><subject>Seminal Plasma Proteins - genetics</subject><subject>Seminal Plasma Proteins - immunology</subject><subject>Sex</subject><subject>Sex chromosomes</subject><subject>Sex Chromosomes - genetics</subject><subject>Sex Differentiation - genetics</subject><subject>Sex Preselection - methods</subject><subject>Sex Preselection - veterinary</subject><subject>sorting</subject><subject>Sperm</subject><subject>Spermatogenesis</subject><subject>spermatozoa</subject><subject>Spermatozoa - cytology</subject><subject>Spermatozoa - immunology</subject><subject>Spermatozoa - metabolism</subject><subject>Transcription</subject><subject>transcription (genetics)</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90d9PFDEQB_DGQATBJ9-lb5qY1U637W4fDQE1IYEoPDfd_rir3G6Pzl4C_z097vSRp04mn8yk8yXkA7CvIFv27ffFTQPQMM77N-QYOgFN12t9UGvRsQYUV0fkHeJfxkD2nXpLjjhoACH4Mbm_LXZCV9J6TnmyK-qfJjsmhzRHOi8DxfBI3bLkMWMeA1I7-X3fFrekMZcqI65LmhZb3OA6uBSTq3JOizAhTROtzTKeksNoVxje798Tcnd5cXv-s7m6_vHr_PtVM8iWz007CK9U8C4IFTiEKHvJfe-c99BGcJ7Z6DrpvFOy9T66IQrNvB5s4N2g-vaEfNrNXZf8sAk4mzGhC6uVnULeoNGMs16Jvq3y86sSGHRaMa1lpV921JWMWEI09cujLU8VmW0OpuZgAMw2h6o_7gdvhjH4__bf4Ss424Fos7GLktDc_eEMBGOs0_JlIezEkDK6FOo161Xtq2ufAQvWnwg</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Ellis, Peter J I</creator><creator>Yu, Yong</creator><creator>Zhang, Shujun</creator><general>BioScientifica</general><general>BioScientifica Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Transcriptional dynamics of the sex chromosomes and the search for offspring sex-specific antigens in sperm</title><author>Ellis, Peter J I ; Yu, Yong ; Zhang, Shujun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b532t-3b4d66edce46e21ef5852d8ccdd13f1cd0afc75cdc653ddfcbf490d9bae27b683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>animal husbandry</topic><topic>Animals</topic><topic>antigens</topic><topic>Antigens - genetics</topic><topic>Antigens - isolation & purification</topic><topic>Antigens - metabolism</topic><topic>Cattle</topic><topic>Female</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation</topic><topic>Germ cells</topic><topic>Humans</topic><topic>Husbandry</topic><topic>Kinetics</topic><topic>Male</topic><topic>Meiosis</topic><topic>Models, Biological</topic><topic>progeny</topic><topic>Review</topic><topic>Seminal Plasma Proteins - genetics</topic><topic>Seminal Plasma Proteins - immunology</topic><topic>Sex</topic><topic>Sex chromosomes</topic><topic>Sex Chromosomes - genetics</topic><topic>Sex Differentiation - genetics</topic><topic>Sex Preselection - methods</topic><topic>Sex Preselection - veterinary</topic><topic>sorting</topic><topic>Sperm</topic><topic>Spermatogenesis</topic><topic>spermatozoa</topic><topic>Spermatozoa - cytology</topic><topic>Spermatozoa - immunology</topic><topic>Spermatozoa - metabolism</topic><topic>Transcription</topic><topic>transcription (genetics)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ellis, Peter J I</creatorcontrib><creatorcontrib>Yu, Yong</creatorcontrib><creatorcontrib>Zhang, Shujun</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ellis, Peter J I</au><au>Yu, Yong</au><au>Zhang, Shujun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transcriptional dynamics of the sex chromosomes and the search for offspring sex-specific antigens in sperm</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>142</volume><issue>5</issue><spage>609</spage><epage>619</epage><pages>609-619</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>The ability to pre-select offspring sex via separation of X- and Y-bearing sperm would have profound ramifications for the animal husbandry industry. 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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | animal husbandry Animals antigens Antigens - genetics Antigens - isolation & purification Antigens - metabolism Cattle Female Gene Expression Profiling Gene Expression Regulation Germ cells Humans Husbandry Kinetics Male Meiosis Models, Biological progeny Review Seminal Plasma Proteins - genetics Seminal Plasma Proteins - immunology Sex Sex chromosomes Sex Chromosomes - genetics Sex Differentiation - genetics Sex Preselection - methods Sex Preselection - veterinary sorting Sperm Spermatogenesis spermatozoa Spermatozoa - cytology Spermatozoa - immunology Spermatozoa - metabolism Transcription transcription (genetics) |
| title | Transcriptional dynamics of the sex chromosomes and the search for offspring sex-specific antigens in sperm |
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