IV Delivery of Induced Pluripotent Stem Cells Attenuates Endotoxin-Induced Acute Lung Injury in Mice

Background Induced pluripotent stem (iPS) cells are novel stem cell populations, but the role of iPS cells in acute lung injury (ALI) is not currently known. We investigated the effect of iPS cells in modifying the pathophysiology of endotoxin-induced ALI. Methods Male C57BL/6 8- to 12-week-old mice...

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Veröffentlicht in:	Chest 2011-11, Vol.140 (5), p.1243-1253
Hauptverfasser:	Yang, Kuang-Yao, MD, PhD, Shih, Hsin-Chin, MD, PhD, How, Chorng-Kuang, MD, Chen, Cheng-Yu, MD, PhD, Hsu, Han-Shui, MD, PhD, Yang, Ching-Wen, BS, Lee, Yu-Chin, MD, FCCP, Perng, Reury-Perng, MD, PhD, FCCP, Peng, Chi-Hsien, MD, Li, Hsin-Yang, MD, PhD, Chang, Chia-Ming, MD, Mou, Chung-Yuan, PhD, Chiou, Shih-Hwa, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - diagnostic imaging Acute Lung Injury - physiopathology Acute Lung Injury - therapy Analysis of Variance Animals Biological and medical sciences Blood Gas Analysis Cardiology. Vascular system Coculture Techniques Cytokines - analysis Delivery. Postpartum. Lactation Endotoxins Enzyme-Linked Immunosorbent Assay Gynecology. Andrology. Obstetrics Immunohistochemistry Induced Pluripotent Stem Cells Luminescent Measurements Male Medical sciences Mice Mice, Inbred C57BL Neutrophils - metabolism NF-kappa B - metabolism Pneumology Pulmonary/Respiratory Radionuclide Imaging Respiratory Function Tests
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