The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles
Abstract The interthalamic adhesion is a unique feature of the third ventricle in the brain. It differs in shape and size and its location varies between individuals. In this study, computational fluid dynamics was performed on 4 three-dimensional models of the cerebral ventricular system with the i...
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| Veröffentlicht in: | Journal of biomechanics 2010-02, Vol.43 (3), p.579-582 |
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| description | Abstract The interthalamic adhesion is a unique feature of the third ventricle in the brain. It differs in shape and size and its location varies between individuals. In this study, computational fluid dynamics was performed on 4 three-dimensional models of the cerebral ventricular system with the interthalamic adhesion modeled in different locations in the third ventricle. Cerebrospinal fluid (CSF) was modeled as incompressible Newtonian fluid and flow was assumed laminar. The periodic motion of CSF flow as a function of the cardiac cycle starting from diastole was prescribed as the inlet boundary condition at the foramen of Monroe. Results from this study show how the location of the interthalamic adhesion influences the pattern of pressure distribution in the cerebral ventricles. In addition, the highest CSF pressure in the third ventricle can vary by ∼50% depending on the location of the interthalamic adhesion. We suggest that the interthalamic adhesion may have functional implications on the development of hydrocephalus and it is important to model this anatomical feature in future studies. |
| doi_str_mv | 10.1016/j.jbiomech.2009.10.002 |
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It differs in shape and size and its location varies between individuals. In this study, computational fluid dynamics was performed on 4 three-dimensional models of the cerebral ventricular system with the interthalamic adhesion modeled in different locations in the third ventricle. Cerebrospinal fluid (CSF) was modeled as incompressible Newtonian fluid and flow was assumed laminar. The periodic motion of CSF flow as a function of the cardiac cycle starting from diastole was prescribed as the inlet boundary condition at the foramen of Monroe. Results from this study show how the location of the interthalamic adhesion influences the pattern of pressure distribution in the cerebral ventricles. In addition, the highest CSF pressure in the third ventricle can vary by ∼50% depending on the location of the interthalamic adhesion. We suggest that the interthalamic adhesion may have functional implications on the development of hydrocephalus and it is important to model this anatomical feature in future studies.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2009.10.002</identifier><identifier>PMID: 19896132</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adhesion ; Adhesiveness ; Biological and medical sciences ; Biomechanics. Biorheology ; Boundary conditions ; Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges ; Cerebral ventricles ; Cerebral Ventricles - physiology ; Cerebrospinal fluid ; Cerebrospinal Fluid - physiology ; Computational fluid dynamics ; Computer Simulation ; Computerized, statistical medical data processing and models in biomedicine ; Fundamental and applied biological sciences. Psychology ; Humans ; Interthalamic adhesion ; Intracranial Pressure - physiology ; Medical sciences ; Models and simulation ; Models, Biological ; Physical Medicine and Rehabilitation ; Reynolds number ; Studies ; Thalamus - physiology ; Tissues, organs and organisms biophysics ; Vertebrates: nervous system and sense organs</subject><ispartof>Journal of biomechanics, 2010-02, Vol.43 (3), p.579-582</ispartof><rights>2009</rights><rights>2015 INIST-CNRS</rights><rights>Crown Copyright 2009. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-7e731a39a37e312148279f627088cbfb72bd5c3b57a31fc1309d7de934bf29153</citedby><cites>FETCH-LOGICAL-c512t-7e731a39a37e312148279f627088cbfb72bd5c3b57a31fc1309d7de934bf29153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1034954537?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22514082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19896132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Shaokoon</creatorcontrib><creatorcontrib>Tan, Kristy</creatorcontrib><creatorcontrib>Bilston, Lynne E</creatorcontrib><title>The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>Abstract The interthalamic adhesion is a unique feature of the third ventricle in the brain. It differs in shape and size and its location varies between individuals. In this study, computational fluid dynamics was performed on 4 three-dimensional models of the cerebral ventricular system with the interthalamic adhesion modeled in different locations in the third ventricle. Cerebrospinal fluid (CSF) was modeled as incompressible Newtonian fluid and flow was assumed laminar. The periodic motion of CSF flow as a function of the cardiac cycle starting from diastole was prescribed as the inlet boundary condition at the foramen of Monroe. Results from this study show how the location of the interthalamic adhesion influences the pattern of pressure distribution in the cerebral ventricles. In addition, the highest CSF pressure in the third ventricle can vary by ∼50% depending on the location of the interthalamic adhesion. We suggest that the interthalamic adhesion may have functional implications on the development of hydrocephalus and it is important to model this anatomical feature in future studies.</description><subject>Adhesion</subject><subject>Adhesiveness</subject><subject>Biological and medical sciences</subject><subject>Biomechanics. Biorheology</subject><subject>Boundary conditions</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Cerebral ventricles</subject><subject>Cerebral Ventricles - physiology</subject><subject>Cerebrospinal fluid</subject><subject>Cerebrospinal Fluid - physiology</subject><subject>Computational fluid dynamics</subject><subject>Computer Simulation</subject><subject>Computerized, statistical medical data processing and models in biomedicine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Interthalamic adhesion</subject><subject>Intracranial Pressure - physiology</subject><subject>Medical sciences</subject><subject>Models and simulation</subject><subject>Models, Biological</subject><subject>Physical Medicine and Rehabilitation</subject><subject>Reynolds number</subject><subject>Studies</subject><subject>Thalamus - physiology</subject><subject>Tissues, organs and organisms biophysics</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkktr3DAQx0VpabZpv0IwlNKTN3rYlnUpLaGPQKCHJGchyyNWrh9bjR3Yb99xd9tALoEBSaPfjGbmL8YuBN8KLqrLbts1cRrA77aSc0POLefyBduIWqtcqpq_ZBvyiNxIw8_YG8SOc64LbV6zM2FqUwklN2y420EGIYCfMZtCNtMxjjOkeed6N0SfuXYHGKcx208Y53VD5iFBkybcx9H1WeiX2GbtYVwDkOL_pjkydP0A45yi7wHfslfB9QjvTus5u__29e7qR37z8_v11Zeb3JdCzrkGrYRTxikNSkhR1FKbUEnN69o3odGyaUuvmlI7JYIXiptWt2BU0QRpRKnO2cdj3n2afi-Asx0ieuh7N8K0oDU0Qi21lM-SWqm6LkwpiHz_hOymJVH7aAVXhBSl0kRVR8rTdDBBsPsUB5cOBNlVOdvZf8rZVbnVTzpR4MUp_dIM0D6GnaQi4MMJcOhdH5IbfcT_nJSlKHi9cp-PHNCAHyIkiz7C6KGNiVS27RSfr-XTkxS-j2OkV3_BAfCxb4vScnu7_rP1m3GysqJq_wCUnM6w</recordid><startdate>20100210</startdate><enddate>20100210</enddate><creator>Cheng, Shaokoon</creator><creator>Tan, Kristy</creator><creator>Bilston, Lynne E</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100210</creationdate><title>The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles</title><author>Cheng, Shaokoon ; Tan, Kristy ; Bilston, Lynne E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-7e731a39a37e312148279f627088cbfb72bd5c3b57a31fc1309d7de934bf29153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adhesion</topic><topic>Adhesiveness</topic><topic>Biological and medical sciences</topic><topic>Biomechanics. Biorheology</topic><topic>Boundary conditions</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Cerebral ventricles</topic><topic>Cerebral Ventricles - physiology</topic><topic>Cerebrospinal fluid</topic><topic>Cerebrospinal Fluid - physiology</topic><topic>Computational fluid dynamics</topic><topic>Computer Simulation</topic><topic>Computerized, statistical medical data processing and models in biomedicine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Interthalamic adhesion</topic><topic>Intracranial Pressure - physiology</topic><topic>Medical sciences</topic><topic>Models and simulation</topic><topic>Models, Biological</topic><topic>Physical Medicine and Rehabilitation</topic><topic>Reynolds number</topic><topic>Studies</topic><topic>Thalamus - physiology</topic><topic>Tissues, organs and organisms biophysics</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Shaokoon</creatorcontrib><creatorcontrib>Tan, Kristy</creatorcontrib><creatorcontrib>Bilston, Lynne E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Shaokoon</au><au>Tan, Kristy</au><au>Bilston, Lynne E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles</atitle><jtitle>Journal of biomechanics</jtitle><addtitle>J Biomech</addtitle><date>2010-02-10</date><risdate>2010</risdate><volume>43</volume><issue>3</issue><spage>579</spage><epage>582</epage><pages>579-582</pages><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>Abstract The interthalamic adhesion is a unique feature of the third ventricle in the brain. It differs in shape and size and its location varies between individuals. In this study, computational fluid dynamics was performed on 4 three-dimensional models of the cerebral ventricular system with the interthalamic adhesion modeled in different locations in the third ventricle. Cerebrospinal fluid (CSF) was modeled as incompressible Newtonian fluid and flow was assumed laminar. The periodic motion of CSF flow as a function of the cardiac cycle starting from diastole was prescribed as the inlet boundary condition at the foramen of Monroe. Results from this study show how the location of the interthalamic adhesion influences the pattern of pressure distribution in the cerebral ventricles. In addition, the highest CSF pressure in the third ventricle can vary by ∼50% depending on the location of the interthalamic adhesion. We suggest that the interthalamic adhesion may have functional implications on the development of hydrocephalus and it is important to model this anatomical feature in future studies.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19896132</pmid><doi>10.1016/j.jbiomech.2009.10.002</doi><tpages>4</tpages></addata></record> |
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| subjects | Adhesion Adhesiveness Biological and medical sciences Biomechanics. Biorheology Boundary conditions Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebral ventricles Cerebral Ventricles - physiology Cerebrospinal fluid Cerebrospinal Fluid - physiology Computational fluid dynamics Computer Simulation Computerized, statistical medical data processing and models in biomedicine Fundamental and applied biological sciences. Psychology Humans Interthalamic adhesion Intracranial Pressure - physiology Medical sciences Models and simulation Models, Biological Physical Medicine and Rehabilitation Reynolds number Studies Thalamus - physiology Tissues, organs and organisms biophysics Vertebrates: nervous system and sense organs |
| title | The effects of the interthalamic adhesion position on cerebrospinal fluid dynamics in the cerebral ventricles |
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